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The Department of Chemical and Systems Biology Presents Cutting Lecture Series: Amit Choudhary

The Department of Chemical and Systems Biology Presents Cutting Lecture Series: Amit Choudhary

Amit Choudhary, Ph.D.
Broad Institute of Harvard and MIT
Harvard Medical School
Brigham and Women’s Hospital
Joslin Diabetes Center

Friday, October 21, 2022
12:30 PM – 1:30 PM (Pacific Time)

Munzer Auditorium (In-person)

Talk Title: “Chemical approaches to genome and protein editing”

Abstract: My laboratory focuses on applying chemistry-based approaches to propel the development of molecular and cellular modalities for various disorders. I will briefly introduce our efforts in cellular engineering using CRISPR-based technologies and the development of zinc-based prodrug systems, but my presentation will focus on Phosphorylation-Inducing Chimeric Small molecules (PHICS). Small molecules have been classically used to inhibit enzyme function (i.e., loss-of-function), but several new classes of small molecules are emerging that endow neo-functions to enzymes via proximity-mediated effects. I will describe the development and applications of PHICS, which can induce phosphorylation of a given target protein by forcing proximity between a kinase and the target protein.

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