Category: James E. Ferrell

Graham Anderson, Lendert Gelens, Julie Baker, and Jim Ferrell featured on the cover of Cell Reports

Graham Anderson, Lendert Gelens, Julie Baker, and Jim Ferrell featured on the cover of Cell Reports

The cover image shows the early cell divisions of the Xenopus laevis embryo occur in spatial waves. To observe these cell division waves, Anderson et al. used mirrors and time-lapse microscopy to view embryos from multiple angles. The image shows a single eight-cell embryo resting on two opposing mirrors angled 45° from horizontal. The metal background is a machined aluminum temperature-control device that maintained the embryo at 18°C. Image by Graham Anderson and Lendert Gelens.

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New Theory Suggests That Negative Cooperativity Can Make A Switch-Life Response In Signaling

The standard theory on negative cooperativity where the binding of one ligand makes it harder for a second ligand to bind to multi-subunit receptors says that the higher the negative cooperativity, the more graded the receptor’s response. It turns out that there is a little algebraic shortcut built into the standard theory, but in many situations, especially intracellular signaling, this assumption does not hold.

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