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Oncogenic SF3B1 mutations alter the splicing of mRNA noncoding regions to induce a novel therapeutic vulnerability.

Sekrecki M, Sekrecka A, Lattupally RR, Le K, Jin X, Mozes C, Dwyer BG, Zhuang Z, Romero BA, Pineda JMB, Cao X, Nguyen L, Chen V, Zhou CM, Wallace JA, Tanaka K, Tiwari C, Gabel A, Kim WJ, Stanley RF, Benbarche S, Thind J, Muruganandham A, Zhang TY, Greenberg PL, Gotlib JR, Mannis G, Shomali WE, Salmasi G, Kuo C, Shanafelt T, Singh I, Inoue D, Hansen FK, Gray NS, van Rechem C, Fakhri B, Zhang X, Lu SX. Blood. 2026 Apr 23;147(17):1941-1957. doi: 10.1182/blood.2025029972. PMID: 41587094; PMCID: PMC13155965. [PubMed]

Inhibitors supercharge kinase turnover through native proteolytic circuits.

Scholes NS, Bertoni M, Comajuncosa-Creus A, Kladnik K, Guo X, Frommelt F, Hinterndorfer M, Razumkov H, Prokofeva P, Schwalm MP, Born F, Roehm S, Imrichova H, Santini BL, Barone E, Schätz C, Muñoz I Ordoño M, Lechner S, Rukavina A, Serrano I, Abele M, Koren A, Kubicek S, Knapp S, Gray NS, Superti-Furga G, Kuster B, Shi Y, Aloy P, Winter GE. Nature. 2026 Jan;649(8098):1032-1041. doi: 10.1038/s41586-025-09763-9. Epub 2025 Nov 26. PMID: 41299171; PMCID: PMC12823440. [PubMed]

Defining the Antitumor Mechanism of Action of a Clinical-stage Compound as a Selective Degrader of the Nuclear Pore Complex.

Yuan L, Ji W, Dwyer BG, Lu J, Bian J, Colombo GM, Martinez MJ, Fernandez D, Phillips NA, Tang MT, Zhou CW, Quispe Calla NE, Guzman Huancas C, Eckart M, Tran J, Jones HM, Qiu T, Doench JG, Rees MG, Roth JA, Cameron MD, Charville GW, Kuo CJ, Dixon SJ, Zhang T, Hinshaw SM, Gray NS, Corsello SM. Cancer Discov. 2025 Dec 2;15(12):2505-2529. doi: 10.1158/2159-8290.CD-25-0271. PMID: 40891634; PMCID: PMC12670082. [PubMed]

Relocalizing transcriptional kinases to activate apoptosis.

Sarott RC, Gourisankar S, Karim B, Nettles S, Yang H, Dwyer BG, Simanauskaite JM, Tse J, Abuzaid H, Krokhotin A, Zhang T, Hinshaw SM, Green MR, Crabtree GR, Gray NS. Science. 2024 Oct 4;386(6717):eadl5361. doi: 10.1126/science.adl5361. Epub 2024 Oct 4. PMID: 39361741; PMCID: PMC11629774. [PubMed]

Rewiring cancer drivers to activate apoptosis.

Gourisankar S, Krokhotin A, Ji W, Liu X, Chang CY, Kim SH, Li Z, Wenderski W, Simanauskaite JM, Yang H, Vogel H, Zhang T, Green MR, Gray NS, Crabtree GR. Nature. 2023 Aug;620(7973):417-425. doi: 10.1038/s41586-023-06348-2. Epub 2023 Jul 26. Erratum in: Nature. 2023 Sep;621(7977):E27. doi: 10.1038/s41586-023-06543-1. PMID: 37495688; PMCID: PMC10749586. [PubMed]

Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development.

Donovan KA, Ferguson FM, Bushman JW, Eleuteri NA, Bhunia D, Ryu S, Tan L, Shi K, Yue H, Liu X, Dobrovolsky D, Jiang B, Wang J, Hao M, You I, Teng M, Liang Y, Hatcher J, Li Z, Manz TD, Groendyke B, Hu W, Nam Y, Sengupta S, Cho H, Shin I, Agius MP, Ghobrial IM, Ma MW, Che J, Buhrlage SJ, Sim T, Gray NS, Fischer ES. Cell. 2020 Dec 10;183(6):1714-1731.e10. doi: 10.1016/j.cell.2020.10.038. Epub 2020 Dec 3. PMID: 33275901; PMCID: PMC10294644. [PubMed]

Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2.

Taylor MS, Chen M, Hancock M, Wranik M, Miller BD, O'Meara TR, Palanski BA, Ficarro SB, Groendyke BJ, Xiang Y, Kondo KT, Linde-Garelli KY, Lee MJ, Mondal D, Freund D, Congreve S, Matas K, Hennink M, Xibinaku K, Valenstein ML, van Eeuwen T, Marto JA, Sali A, Shi Y, Gray NS, Sabatini DM, Chu N, Rogala KB, Cole PA. Science. 2026 Mar 5;391(6789):eadv7111. doi: 10.1126/science.adv7111. Epub 2026 Mar 5. PMID: 41308123; PMCID: PMC12830033. [PubMed]

 
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