Publications

Affordable IgY-based antiviral prophylaxis for resource-limited settings to address epidemic and pandemic risks.

Chen CJ, Hudson AF, Jia AS, Kunchur CR, Song AJ, Tran E, Fisher CJ, Zanchi D, Lee L, Kargotich S, Romeo M, Koperniku A, Pamnani RD, Mochly-Rosen D. J Glob Health. 2022 Feb 26;12:05009. doi: 10.7189/jogh.12.05009. eCollection 2022. PMID: 35265332 Free PMC article. [PubMed]

Alcohol Consumption, ALDH2 Polymorphism as Risk Factors for Upper Aerodigestive Tract Cancer Progression and Prognosis.

Chen CH, Wang WL, Hsu MH, Mochly-Rosen D. Life (Basel). 2022 Feb 27;12(3):348. doi: 10.3390/life12030348. PMID: 35330099 Free PMC article. Review. [PubMed]

A Selective Inhibitor of Cardiac Troponin I Phosphorylation by Delta Protein Kinase C (δPKC) as a Treatment for Ischemia-Reperfusion Injury.

Qvit N, Lin AJ, Elezaby A, Ostberg NP, Campos JC, Ferreira JCB, Mochly-Rosen D. Pharmaceuticals (Basel). 2022 Feb 22;15(3):271. doi: 10.3390/ph15030271. PMID: 35337069 Free PMC article. [PubMed]

ALDH2 Expression, Alcohol Intake, and Semen Parameters Among East Asian Men.

Greenberg DR, Bhambvani HP, Basran SS, Salazar BP, Rios LC, Li SJ, Chen CH, Mochly-Rosen D, Eisenberg ML. J Urol. 2022 Mar 28:101097JU0000000000002682. doi: 10.1097/JU.0000000000002682. Online ahead of print. PMID: 35344413 [PubMed]

CRISPR-mediated Synergistic Epigenetic and Transcriptional Control.

Dominguez AA, Chavez MG, Urke A, Gao Y, Wang L, Qi LS. CRISPR J. 2022 Mar 10. doi: 10.1089/crispr.2021.0099. Online ahead of print. PMID: 35271371 [PubMed]

Boosting the Discovery of Small Molecule Inhibitors of Glucose-6-Phosphate Dehydrogenase for the Treatment of Cancer, Infectious Diseases, and Inflammation.

Koperniku A, Garcia AA, Mochly-Rosen D. J Med Chem. 2022 Mar 3. doi: 10.1021/acs.jmedchem.1c01577. Online ahead of print. PMID: 35239352 [PubMed]

Multi-color super-resolution imaging to study human coronavirus RNA during cellular infection.

Wang J, Han M, Roy AR, Wang H, Möckl L, Zeng L, Moerner WE, Qi LS. Cell Rep Methods. 2022 Feb 28;2(2):100170. doi: 10.1016/j.crmeth.2022.100170. Epub 2022 Feb 1. PMID: 35128513 Free PMC article. [PubMed]

Dual CRISPR interference and activation for targeted reactivation of X-linked endogenous FOXP3 in human breast cancer cells.

Cui X, Zhang C, Xu Z, Wang S, Li X, Stringer-Reasor E, Bae S, Zeng L, Zhao D, Liu R, Qi LS, Wang L. Mol Cancer. 2022 Feb 7;21(1):38. doi: 10.1186/s12943-021-01472-x. PMID: 35130925 Free PMC article. [PubMed]

The use of new CRISPR tools in cardiovascular research and medicine.

Nishiga M, Liu C, Qi LS, Wu JC. Nat Rev Cardiol. 2022 Feb 10. doi: 10.1038/s41569-021-00669-3. Online ahead of print. PMID: 35145236 Review. [PubMed]

Roles of transposable elements in the regulation of mammalian transcription.

Fueyo R, Judd J, Feschotte C, Wysocka J. Nat Rev Mol Cell Biol. 2022 Feb 28. doi: 10.1038/s41580-022-00457-y. Online ahead of print. PMID: 35228718 Review. [PubMed]

Mitochondrial fusion, fission and mitophagy in cardiac diseases: challenges and therapeutic opportunities.

Scheffer DDL, Garcia AA, Lee L, Mochly-Rosen D, Ferreira JCB. Antioxid Redox Signal. 2022 Jan 19. doi: 10.1089/ars.2021.0145. Online ahead of print. PMID: 35044229 [PubMed]

Stabilization of glucose-6-phosphate dehydrogenase oligomers enhances catalytic activity and stability of clinical variants.

Garcia AA, Mathews II, Horikoshi N, Matsui T, Kaur M, Wakatsuki S, Mochly-Rosen D. J Biol Chem. 2022 Jan 19:101610. doi: 10.1016/j.jbc.2022.101610. Online ahead of print. [PubMed]

Drp1/Fis1-Dependent Pathologic Fission and Associated Damaged Extracellular Mitochondria Contribute to Macrophage Dysfunction in Endotoxin Tolerance.

Mukherjee R, Tompkins CA, Ostberg NP, Joshi AU, Massis LM, Vijayan V, Gera K, Monack D, Cornell TT, Hall MW, Mochly-Rosen D, Haileselassie B. Crit Care Med. 2022 Jan 24. doi: 10.1097/CCM.0000000000005437. Online ahead of print. PMID: 35067534 [PubMed]

Treatment-refractory ulcerative colitis responsive to indigo naturalis.

Saiki JP, Andreasson JO, Grimes KV, Frumkin LR, Sanjines E, Davidson MG, Park KT, Limketkai B. BMJ Open Gastroenterol. 2021 Dec;8(1):e000813. doi: 10.1136/bmjgast-2021-000813. PMID: 34969665 [PubMed]

Activation of PKCε-ALDH2 Axis Prevents 4-HNE-Induced Pain in Mice

Martins BB, Hösch NG, Alcantara QA, Budas GR, Chen CH, Mochly-Rosen D, Ferreira JCB, Zambelli VO. Biomolecules. 2021 Nov 30;11(12):1798. doi: 10.3390/biom11121798. PMID: 34944441 [PubMed]

Stepwise oxidations play key roles in the structural and functional regulations of DJ-1

Song IK, Kim MS, Ferrell JE Jr, Shin DH, Lee KJ. Biochem J. 2021 Oct 15;478(19):3505-3525. doi: 10.1042/BCJ20210245. PMID: 34515295 [PubMed]

Enhanced Cas12a multi-gene regulation using a CRISPR array separator.

Magnusson JP, Rios AR, Wu L, Qi LS. Elife. 2021 Sep 9;10:e66406. doi: 10.7554/eLife.66406. PMID: 34499031 [PubMed]

Contextual reprogramming of CAR-T cells for treatment of HER2+ cancers.

Yang Z, Li L, Turkoz A, Chen P, Harari-Steinfeld R, Bobbin M, Stefanson O, Choi H, Pietrobon V, Alphson B, Goswami A, Balan V, Kearney A, Patel D, Yang J, Inel D, Vinod V, Cesano A, Wang B, Roh KH, Qi LS, Marincola FM. J Transl Med. 2021 Nov 7;19(1):459. doi: 10.1186/s12967-021-03132-6. PMID: 34743703 [PubMed]

Small Molecule Control of Morpholino Antisense Oligonucleotide Function through Staudinger Reduction.

Darrah K, Wesalo J, Lukasak B, Tsang M, Chen JK, Deiters A. J Am Chem Soc. 2021 Oct 27. doi: 10.1021/jacs.1c08723. Online ahead of print. PMID: 34705461 [PubMed]

Protein aggregation and the evolution of stress resistance in clinical yeast.

Chen YR, Ziv I, Swaminathan K, Elias JE, Jarosz DF. Philos Trans R Soc Lond B Biol Sci. 2021 Jun 7;376(1826):20200127. doi: 10.1098/rstb.2020.0127. Epub 2021 Apr 19. PMID: 33866806 [PubMed]

A prion accelerates proliferation at the expense of lifespan.

Garcia DM, Campbell EA, Jakobson CM, Tsuchiya M, Shaw EA, DiNardo AL, Kaeberlein M, Jarosz DF. Elife. 2021 Sep 15;10:e60917. doi: 10.7554/eLife.60917. PMID: 34545808 [PubMed]

Metabolites control stress granule disassembly.

Jakobson CM, Jarosz DF. Nat Cell Biol. 2021 Oct;23(10):1053-1055. doi: 10.1038/s41556-021-00768-w. PMID: 34616025 [PubMed]

Massive QTL analysis identifies pleiotropic genetic determinants for stress resistance, aroma formation, and ethanol, glycerol and isobutanol production in Saccharomyces cerevisiae.

Ho PW, Piampongsant S, Gallone B, Del Cortona A, Peeters PJ, Reijbroek F, Verbaet J, Herrera B, Cortebeeck J, Nolmans R, Saels V, Steensels J, Jarosz DF, Verstrepen KJ. Biotechnol Biofuels. 2021 Nov 2;14(1):211. doi: 10.1186/s13068-021-02059-w. PMID: 34727964 [PubMed]

Annotation of 1350 Common Genetic Variants of the 19 ALDH Multigene Family from Global Human Genome Aggregation Database (gnomAD).

Chen CH, Kraemer BR, Lee L, Mochly-Rosen D. Biomolecules. 2021 Sep 29;11(10):1423. doi: 10.3390/biom11101423. PMID: 34680056 [PubMed]

Activation of Aldehyde Dehydrogenase 2 Ameliorates Glucolipotoxicity of Pancreatic Beta Cells.

Chen SM, Hee SW, Chou SY, Liu MW, Chen CH, Mochly-Rosen D, Chang TJ, Chuang LM. Biomolecules. 2021 Oct 6;11(10):1474. doi: 10.3390/biom11101474. PMID: 34680107 [PubMed]