Publications

Small Molecule Control of Morpholino Antisense Oligonucleotide Function through Staudinger Reduction.

Darrah K, Wesalo J, Lukasak B, Tsang M, Chen JK, Deiters A. J Am Chem Soc. 2021 Oct 27. doi: 10.1021/jacs.1c08723. Online ahead of print. PMID: 34705461 [PubMed]

Protein aggregation and the evolution of stress resistance in clinical yeast.

Chen YR, Ziv I, Swaminathan K, Elias JE, Jarosz DF. Philos Trans R Soc Lond B Biol Sci. 2021 Jun 7;376(1826):20200127. doi: 10.1098/rstb.2020.0127. Epub 2021 Apr 19. PMID: 33866806 [PubMed]

A prion accelerates proliferation at the expense of lifespan.

Garcia DM, Campbell EA, Jakobson CM, Tsuchiya M, Shaw EA, DiNardo AL, Kaeberlein M, Jarosz DF. Elife. 2021 Sep 15;10:e60917. doi: 10.7554/eLife.60917. PMID: 34545808 [PubMed]

Metabolites control stress granule disassembly.

Jakobson CM, Jarosz DF. Nat Cell Biol. 2021 Oct;23(10):1053-1055. doi: 10.1038/s41556-021-00768-w. PMID: 34616025 [PubMed]

Massive QTL analysis identifies pleiotropic genetic determinants for stress resistance, aroma formation, and ethanol, glycerol and isobutanol production in Saccharomyces cerevisiae.

Ho PW, Piampongsant S, Gallone B, Del Cortona A, Peeters PJ, Reijbroek F, Verbaet J, Herrera B, Cortebeeck J, Nolmans R, Saels V, Steensels J, Jarosz DF, Verstrepen KJ. Biotechnol Biofuels. 2021 Nov 2;14(1):211. doi: 10.1186/s13068-021-02059-w. PMID: 34727964 [PubMed]

Annotation of 1350 Common Genetic Variants of the 19 ALDH Multigene Family from Global Human Genome Aggregation Database (gnomAD).

Chen CH, Kraemer BR, Lee L, Mochly-Rosen D. Biomolecules. 2021 Sep 29;11(10):1423. doi: 10.3390/biom11101423. PMID: 34680056 [PubMed]

Activation of Aldehyde Dehydrogenase 2 Ameliorates Glucolipotoxicity of Pancreatic Beta Cells.

Chen SM, Hee SW, Chou SY, Liu MW, Chen CH, Mochly-Rosen D, Chang TJ, Chuang LM. Biomolecules. 2021 Oct 6;11(10):1474. doi: 10.3390/biom11101474. PMID: 34680107 [PubMed]

δPKC-Mediated Drp1 Phosphorylation Impacts Macrophage Mitochondrial Function and Inflammatory Response to Endotoxin.

Lin AJ, Joshi AU, Mukherjee R, Tompkins CA, Vijayan V, Mochly-Rosen D, Haileselassie B. Shock. 2021 Nov 3. doi: 10.1097/SHK.0000000000001885. Online ahead of print. PMID: 34738957 [PubMed]

Genome scans of facial features in East Africans and cross-population comparisons reveal novel associations.

Liu C, Lee MK, Naqvi S, Hoskens H, Liu D, White JD, Indencleef K, Matthews H, Eller RJ, Li J, Mohammed J, Swigut T, Richmond S, Manyama M, Hallgrímsson B, Spritz RA, Feingold E, Marazita ML, Wysocka J, Walsh S, Shriver MD, Claes P, Weinberg SM, Shaffer JR. PLoS Genet. 2021 Aug 19;17(8):e1009695. doi: 10.1371/journal.pgen.1009695. eCollection 2021 Aug. PMID: 34411106 [PubMed]

Single-cell transcriptomic profiling reveals distinct mechanical responses between normal and diseased tendon progenitor cells.

Still C 2nd, Chang WT, Sherman SL, Sochacki KR, Dragoo JL, Qi LS. Cell Rep Med. 2021 Jul 21;2(7):100343. doi: 10.1016/j.xcrm.2021.100343. eCollection 2021 Jul 20. PMID: 34337559 [PubMed]

Interrogation of the dynamic properties of higher-order heterochromatin using CRISPR-dCas9.

Gao Y, Han M, Shang S, Wang H, Qi LS. Mol Cell. 2021 Aug 13:S1097-2765(21)00612-2. doi: 10.1016/j.molcel.2021.07.034. Online ahead of print. PMID: 34428454 [PubMed]

Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing.

Xu X, Chemparathy A, Zeng L, Kempton HR, Shang S, Nakamura M, Qi LS. Mol Cell. 2021 Aug 26:S1097-2765(21)00648-1. doi: 10.1016/j.molcel.2021.08.008. Online ahead of print. PMID: 34480847 [PubMed]

Treatment strategies for glucose-6-phosphate dehydrogenase deficiency: past and future perspectives.

Garcia AA, Koperniku A, Ferreira JCB, Mochly-Rosen D. Trends Pharmacol Sci. 2021 Aug 10:S0165-6147(21)00137-1. doi: 10.1016/j.tips.2021.07.002. Online ahead of print. PMID: 34389161 Review. [PubMed]

CRISPRi/a Screening with Human iPSCs.

Nishiga M, Qi LS, Wu JC. Methods Mol Biol. 2021;2320:261-281. doi: 10.1007/978-1-0716-1484-6_23. PMID: 34302664 [PubMed]

Catalytically inactive, purified RNase H1: A specific and sensitive probe for RNA-DNA hybrid imaging.

Crossley MP, Brickner JR, Song C, Zar SMT, Maw SS, Chédin F, Tsai MS, Cimprich KA. J Cell Biol. 2021 Sep 6;220(9):e202101092. doi: 10.1083/jcb.202101092. Epub 2021 Jul 7. PMID: 34232287 [PubMed]

Shared heritability of human face and brain shape.

Naqvi S, Sleyp Y, Hoskens H, Indencleef K, Spence JP, Bruffaerts R, Radwan A, Eller RJ, Richmond S, Shriver MD, Shaffer JR, Weinberg SM, Walsh S, Thompson J, Pritchard JK, Sunaert S, Peeters H, Wysocka J, Claes P. Nat Genet. 2021 Jun;53(6):830-839. doi: 10.1038/s41588-021-00827-w. Epub 2021 Apr 5. PMID: 33821002 [PubMed]

Xenopus laevis Egg Extract Preparation and Live Imaging Methods for Visualizing Dynamic Cytoplasmic Organization.

Cheng X, Ferrell JE Jr. J Vis Exp. 2021 Jun 6;(172). doi: 10.3791/61923. PMID: 34152312 [PubMed]

Natural variants in SARS-CoV-2 Spike protein pinpoint structural and functional hotspots with implications for prophylaxis and therapeutic strategies.

Pokhrel S, Kraemer BR, Burkholz S, Mochly-Rosen D. Sci Rep. 2021 Jun 23;11(1):13120. doi: 10.1038/s41598-021-92641-x. PMID: 34162970 [PubMed]

Immunoglobulin Y for Potential Diagnostic and Therapeutic Applications in Infectious Diseases.

Lee L, Samardzic K, Wallach M, Frumkin LR, Mochly-Rosen D. Front Immunol. 2021 Jun 9;12:696003. doi: 10.3389/fimmu.2021.696003. eCollection 2021. PMID: 34177963 [PubMed]

Paired SARS-CoV-2 spike protein mutations observed during ongoing SARS-CoV-2 viral transfer from humans to minks and back to humans.

Burkholz S, Pokhrel S, Kraemer BR, Mochly-Rosen D, Carback RT 3rd, Hodge T, Harris P, Ciotlos S, Wang L, Herst CV, Rubsamen R. Infect Genet Evol. 2021 May 7;93:104897. doi: 10.1016/j.meegid.2021.104897. Online ahead of print. PMID: 33971305 [PubMed]

Increased elastase sensitivity and decreased intramolecular interactions in the more transmissible 501Y.V1 and 501Y.V2 SARS-CoV-2 variants’ spike protein-an in silico analysis.

Pokhrel S, Kraemer BR, Lee L, Samardzic K, Mochly-Rosen D. PLoS One. 2021 May 26;16(5):e0251426. doi: 10.1371/journal.pone.0251426. eCollection 2021. PMID: 34038453 [PubMed]

Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination-deficient cancer models.

Mehibel M, Xu Y, Li CG, Moon EJ, Thakkar KN, Diep AN, Kim RK, Bloomstein JD, Xiao Y, Bacal J, Saldivar JC, Le QT, Cimprich KA, Rankin EB, Giaccia AJ. J Clin Invest. 2021 Jun 1;131(11):146256. doi: 10.1172/JCI146256. PMID: 34060485 [PubMed]

3D facial phenotyping by biometric sibling matching used in contemporary genomic methodologies.

Hoskens H, Liu D, Naqvi S, Lee MK, Eller RJ, Indencleef K, White JD, Li J, Larmuseau MHD, Hens G, Wysocka J, Walsh S, Richmond S, Shriver MD, Shaffer JR, Peeters H, Weinberg SM, Claes P. PLoS Genet. 2021 May 13;17(5):e1009528. doi: 10.1371/journal.pgen.1009528. eCollection 2021 May. PMID: 33983923 [PubMed]

Real-Time Monitoring of APC /C-Mediated Substrate Degradation Using Xenopus laevis Egg Extracts.

Kamenz J, Qiao R, Yang Q, Ferrell JE Jr. Methods Mol Biol. 2021;2329:29-38. doi: 10.1007/978-1-0716-1538-6_3. PMID: 34085213 [PubMed]

CRISPR-based genome editing in primary human pancreatic islet cells.

Bevacqua RJ, Dai X, Lam JY, Gu X, Friedlander MSH, Tellez K, Miguel-Escalada I, Bonàs-Guarch S, Atla G, Zhao W, Kim SH, Dominguez AA, Qi LS, Ferrer J, MacDonald PE, Kim SK. Nat Commun. 2021 Apr 23;12(1):2397. doi: 10.1038/s41467-021-22651-w. PMID: 33893274 [PubMed]