Publications

Membrane-proximal F-actin restricts local membrane protrusions and directs cell migration.

Bisaria A, Hayer A, Garbett D, Cohen D, Meyer T. Science. 2020 Jun 12;368(6496):1205-1210. doi: 10.1126/science.aay7794. PMID: 32527825. [PubMed]

T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration.

Garbett D, Bisaria A, Yang C, McCarthy DG, Hayer A, Moerner WE, Svitkina TM, Meyer T. Nat Commun. 2020 Sep 23;11(1):4818. doi: 10.1038/s41467-020-18586-3. PMID: 32968060; PMCID: PMC7511357. [PubMed]

Altered G1 signaling order and commitment point in cells proliferating without CDK4/6 activity.

Liu C, Konagaya Y, Chung M, Daigh LH, Fan Y, Yang HW, Terai K, Matsuda M, Meyer T. Nat Commun. 2020 Oct 20;11(1):5305. doi: 10.1038/s41467-020-18966-9. PMID: 33082317; PMCID: PMC7576148. [PubMed]

A Qualitative Study on the Differences Between Trial Populations and the Approved Therapeutic Indications of Antineoplastic Agents by 3 Regulatory Agencies From 2010 to 2018.

Sumi E, Asada R, Lu Y, Ito-Ihara T, Grimes KV. Clin Ther. 2020 Feb;42(2):305-320.e0. doi: 10.1016/j.clinthera.2020.01.002. Epub 2020 Jan 31. PMID: 32008723. [PubMed]

Opposing Effects of Cohesin and Transcription on CTCF Organization Revealed by Super-resolution Imaging.

Gu B, Comerci CJ, McCarthy DG, Saurabh S, Moerner WE, Wysocka J. Mol Cell. 2020 Oct 21:S1097-2765(20)30684-5. doi: 10.1016/j.molcel.2020.10.001. Epub ahead of print. PMID: 33091336. [PubMed]

The Effect of Ethanol Consumption on Composition and Morphology of Femur Cortical Bone in Wild-Type and ALDH2*2-Homozygous Mice.

Malkovskiy AV, Van Wassenhove LD, Goltsev Y, Osei-Sarfo K, Chen CH, Efron B, Gudas LJ, Mochly-Rosen D, Rajadas J. Calcif Tissue Int. 2020 Oct 17. doi: 10.1007/s00223-020-00769-1. Epub ahead of print. PMID: 33068139. [PubMed]

Low-frequency ultrasound-mediated cytokine transfection enhances T cell recruitment at local and distant tumor sites

Ilovitsh T, Feng Y, Foiret J, Kheirolomoom A, Zhang H, Ingham ES, Ilovitsh A, Tumbale SK, Fite BZ, Wu B, Raie MN, Zhang N, Kare AJ, Chavez M, Qi LS, Pelled G, Gazit D, Vermesh O, Steinberg I, Gambhir SS, Ferrara KW. Proc Natl Acad Sci U S A. 2020 Jun 9;117(23):12674-12685. doi: 10.1073/pnas.1914906117. Epub 2020 May 19. PMID: 32430322 [PubMed]

p38 MAPK inhibition: A promising therapeutic approach for COVID-19

Grimes JM, Grimes KV. J Mol Cell Cardiol. 2020 Jul;144:63-65. doi: 10.1016/j.yjmcc.2020.05.007. Epub 2020 May 16. PMID: 32422320 Free PMC article. [PubMed]

FaceBase 3: analytical tools and FAIR resources for craniofacial and dental research

Samuels BD, Aho R, Brinkley JF, Bugacov A, Feingold E, Fisher S, Gonzalez-Reiche AS, Hacia JG, Hallgrimsson B, Hansen K, Harris MP, Ho TV, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Leslie EJ, Li H, Liao EC, Long H, Lu N, Maas RL, Marazita ML, Mohammed J, Prescott S, Schuler R, Selleri L, Spritz RA, Swigut T, van Bakel H, Visel A, Welsh I, Williams C, Williams TJ, Wysocka J, Yuan Y, Chai Y. Development. 2020 Sep 21;147(18):dev191213. doi: 10.1242/dev.191213. PMID: 32958507 [PubMed]

Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder

Long HK, Osterwalder M, Welsh IC, Hansen K, Davies JOJ, Liu YE, Koska M, Adams AT, Aho R, Arora N, Ikeda K, Williams RM, Sauka-Spengler T, Porteus MH, Mohun T, Dickel DE, Swigut T, Hughes JR, Higgs DR, Visel A, Selleri L, Wysocka J. Cell Stem Cell. 2020 Sep 22:S1934-5909(20)30447-1. doi: 10.1016/j.stem.2020.09.001. Online ahead of print. PMID: 32991838 [PubMed]

What Has a Century of Quantitative Genetics Taught Us About Nature’s Genetic Toolkit?

Jakobson CM, Jarosz DF. Annu Rev Genet. 2020 Sep 8. doi: 10.1146/annurev-genet-021920-102037. Online ahead of print. PMID: 32897739 [PubMed]

A Method for Conditional Regulation of Protein Stability in Native or Near-Native Form

Miyamae Y, Chen LC, Utsugi Y, Farrants H, Wandless TJ. Cell Chem Biol. 2020 Sep 24:S2451-9456(20)30376-7. doi: 10.1016/j.chembiol.2020.09.004. Online ahead of print. PMID: 33007216 [PubMed]

Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer’s disease related pathology

Joshi AU, Van Wassenhove LD, Logas KR, Minhas PS, Andreasson KI, Weinberg KI, Chen CH, Mochly-Rosen D. Acta Neuropathol Commun. 2019 Dec 12;7(1):190. doi: 10.1186/s40478-019-0839-7. PMID: 31829281 Free PMC article. [PubMed]

HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis

Bai G, Kermi C, Stoy H, Schiltz CJ, Bacal J, Zaino AM, Hadden MK, Eichman BF, Lopes M, Cimprich KA. Mol Cell. 2020 Jun 18;78(6):1237-1251.e7. doi: 10.1016/j.molcel.2020.04.031. Epub 2020 May 21. PMID: 32442397 Free PMC article. [PubMed]

qDRIP: a method to quantitatively assess RNA-DNA hybrid formation genome-wide.

Crossley MP, Bocek MJ, Hamperl S, Swigut T, Cimprich KA. Nucleic Acids Res. 2020 Aug 20;48(14):e84. doi: 10.1093/nar/gkaa500. PMID: 32544226 [PubMed]

Double Emulsion Picoreactors for High-Throughput Single-Cell Encapsulation and Phenotyping via FACS.

Brower KK, Khariton M, Suzuki PH, Still C 2nd, Kim G, Calhoun SGK, Qi LS, Wang B, Fordyce PM. Anal Chem. 2020 Sep 23. doi: 10.1021/acs.analchem.0c02499. Online ahead of print. PMID: 32900183 [PubMed]

Lentiviral delivery of combinatorial CAR/CRISPRi circuit into human primary T cells is enhanced by TBK1/IKKɛ complex inhibitor BX795.

Li L, Gao Y, Srivastava R, Wang W, Xiong Q, Fang Z, Pelayo A, Denson C, Goswami A, Harari-Steinfeld R, Yang Z, Weng L, Qi LS, Marincola FM. J Transl Med. 2020 Sep 23;18(1):363. doi: 10.1186/s12967-020-02526-2. PMID: 32967676 Free PMC article. [PubMed]

Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza.

Abbott TR, Dhamdhere G, Liu Y, Lin X, Goudy L, Zeng L, Chemparathy A, Chmura S, Heaton NS, Debs R, Pande T, Endy D, La Russa MF, Lewis DB, Qi LS. Cell. 2020 May 14;181(4):865-876.e12. doi: 10.1016/j.cell.2020.04.020. Epub 2020 Apr 29. PMID: 32353252; PMCID: PMC7189862. [PubMed]

Both ROSy and Grim: The Landscape of Protein Redox during Aging.

Chen YR, Jarosz DF. Cell Metab. 2020 Apr 7;31(4):662-663. doi: 10.1016/j.cmet.2020.03.016. PMID: 32268111. [PubMed]

A Prion Epigenetic Switch Establishes an Active Chromatin State.

Harvey ZH, Chakravarty AK, Futia RA, Jarosz DF. Cell. 2020 Mar 5;180(5):928-940.e14. doi: 10.1016/j.cell.2020.02.014. Epub 2020 Feb 27. PMID: 32109413; PMCID: PMC7195540. [PubMed]

HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis.

Bai G, Kermi C, Stoy H, Schiltz CJ, Bacal J, Zaino AM, Hadden MK, Eichman BF, Lopes M, Cimprich KA. Mol Cell. 2020 Jun 18;78(6):1237-1251.e7. doi: 10.1016/j.molcel.2020.04.031. Epub 2020 May 21. PMID: 32442397; PMCID: PMC7305998. [PubMed]

qDRIP: a method to quantitatively assess RNA-DNA hybrid formation genome-wide.

Crossley MP, Bocek MJ, Hamperl S, Swigut T, Cimprich KA. Nucleic Acids Res. 2020 Aug 20;48(14):e84. doi: 10.1093/nar/gkaa500. PMID: 32544226. [PubMed]

The DNA replication fork suppresses CMG unloading from chromatin before termination.

Low E, Chistol G, Zaher MS, Kochenova OV, Walter JC. Genes Dev. 2020 Sep 17. doi: 10.1101/gad.339739.120. Epub ahead of print. PMID: 32943574.Low E, Chistol G, Zaher MS, Kochenova OV, Walter JC. The DNA replication fork suppresses CMG unloading from chromatin before termination. Genes Dev. 2020 Sep 17. doi: 10.1101/gad.339739.120. Epub ahead of print. PMID: 32943574. [PubMed]

Lanthanide-Based Optical Probes of Biological Systems.

Cho U, Chen JK. Cell Chem Biol. 2020 Aug 20;27(8):921-936. doi: 10.1016/j.chembiol.2020.07.009. Epub 2020 Jul 30. PMID: 32735780; PMCID: PMC7484113. [PubMed]

trLRET microscopy: Ultrasensitive imaging of lanthanide luminophores.

Ciepla P, Cho U, Chen JK. Methods Enzymol. 2020;640:225-248. doi: 10.1016/bs.mie.2020.04.030. Epub 2020 May 31. PMID: 32560800. [PubMed]