Publications

Targeting mitochondrial dysfunction and oxidative stress in heart failure: challenges and opportunities.

Kiyuna LA, Prestes E Albuquerque R, Chen CH, Mochly-Rosen D, Ferreira JCB. (2018) Free Radic Biol Med. 2018 Sep 15. pii: S0891-5849(18)31130-4. doi: 10.1016/j.freeradbiomed.2018.09.019. [PubMed]

Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites.

Boucher MJ, Ghosh S, Zhang L, Lal A, Jang SW, Ju A, Zhang S, Wang X, Ralph SA, Zou J, Elias JE, Yeh E. (2018) PLoS Biol. 2018 Sep 13;16(9):e2005895. doi: 10.1371/journal.pbio.2005895. [PubMed]

Surviving in the Valley of Death: Opportunities and Challenges in Translating Academic Drug Discoveries.

Parrish MC, Tan YJ, Grimes KV, Mochly-Rosen D. (2018) Annu Rev Pharmacol Toxicol. 2018 Sep 12. doi: 10.1146/annurev-pharmtox-010818-021625. [PubMed]

Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma.

Purzner T, Purzner J, Buckstaff T, Cozza G, Gholamin S, Rusert JM, Hartl TA, Sanders J, Conley N, Ge X, Langan M, Ramaswamy V, Ellis L, Litzenburger U, Bolin S, Theruvath J, Nitta R, Qi L, Li XN, Li G, Taylor MD, Wechsler-Reya RJ, Pinna LA, Cho YJ, Fuller MT, Elias JE, Scott MP. (2018) Sci Signal. 2018 Sep 11;11(547). pii: eaau5147. doi: 10.1126/scisignal.aau5147. [PubMed]

Proteomic analysis of monolayer-integrated proteins on lipid droplets identifies amphipathic interfacial α-helical membrane anchors.

Pataki CI, Rodrigues J, Zhang L, Qian J, Efron B, Hastie T, Elias JE, Levitt M, Kopito RR. (2018) Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8172-E8180. doi: 10.1073/pnas.1807981115. [PubMed]

An intrinsic S/G2 checkpoint enforced by ATR.

Saldivar JC, Hamperl S, Bocek MJ, Chung M, Bass TE, Cisneros-Soberanis F, Samejima K, Xie L, Paulson JR, Earnshaw WC, Cortez D, Meyer T, Cimprich KA. (2018) Science. 2018 Aug 24;361(6404):806-810. doi: 10.1126/science.aap9346. PubMed PMID: 30139873. [PubMed]

Mutations, protein homeostasis, and epigenetic control of genome integrity.

Xie JL, Jarosz DF. (2018) DNA Repair (Amst). 2018 Aug 23. pii: S1568-7864(18)30169-1. doi: 10.1016/j.dnarep.2018.08.004. [PubMed]

Mortal engines: Mitochondrial bioenergetics and dysfunction in neurodegenerative diseases.

Joshi AU, Mochly-Rosen D. (2018) Pharmacol Res. 2018 Aug 23. pii: S1043-6618(18)30467-5. doi: 10.1016/j.phrs.2018.08.010. [PubMed]

Apoptosis propagates through the cytoplasm as trigger waves.

Cheng X, Ferrell JE Jr. (2018) Science. 2018 Aug 10;361(6402):607-612. doi: 10.1126/science.aah4065. [PubMed]

Systematic perturbation of retroviral LTRs reveals widespread long-range effects on human gene regulation.

Fuentes DR, Swigut T, Wysocka J. (2018) Elife. 2018 Aug 2;7. pii: e35989. doi: 10.7554/eLife.35989. [PubMed]

More than Just a Phase: Prions at the Crossroads of Epigenetic Inheritance and Evolutionary Change.

Chakravarty AK, Jarosz DF. (2018) J Mol Biol. 2018 Jul 18. pii: S0022-2836(18)30809-X. doi: 10.1016/j.jmb.2018.07.017. [PubMed]

Single cell expression analysis of primate-specific retroviruses-derived HPAT lincRNAs in viable human blastocysts identifies embryonic cells co-expressing genetic markers of multiple lineages.

Glinsky G, Durruthy-Durruthy J, Wossidlo M, Grow EJ, Weirather JL, Au KF, Wysocka J, Sebastiano V. (2018) Heliyon. 2018 Jun 28;4(6):e00667. doi: 10.1016/j.heliyon.2018.e00667. [PubMed]

Stochastic Endogenous Replication Stress Causes ATR-Triggered Fluctuations in CDK2 Activity that Dynamically Adjust Global DNA Synthesis Rates.

Daigh LH, Liu C, Chung M, Cimprich KA, Meyer T. (2018) Cell Syst. 2018 Jun 4. pii: S2405-4712(18)30229-1. doi: 10.1016/j.cels.2018.05.011. [PubMed]

Invisible smoke: third-party endorsement and the resurrection of heat-not-burn tobacco products.

Elias J, Ling PM. (2018) Tob Control. 2018 Jun 6. pii:tobaccocontrol-2018-054433. doi: 10.1136/tobaccocontrol-2018-054433. [PubMed]

EMI1 switches from being a substrate to an inhibitor of APC/C(CDH1) to start the cell cycle.

Cappell SD, Mark KG, Garbett D, Pack LR, Rape M, Meyer T. (2018) Nature. 2018 Jun 6. doi: 10.1038/s41586-018-0199-7. [PubMed]

It’s not magic – Hsp90 and its effects on genetic and epigenetic variation.

Zabinsky RA, Mason GA, Queitsch C, Jarosz DF. (2018) Semin Cell Dev Biol. 2018 May 25. pii: S1084-9521(17)30367-1. doi: 10.1016/j.semcdb.2018.05.015. [PubMed]

Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes.

Saiki JP, Cao H, Van Wassenhove LD, Viswanathan V, Bloomstein J, Nambiar DK, Mattingly AJ, Jiang D, Chen CH, Stevens MC, Simmons AL, Park HS, von Eyben R, Kool ET, Sirjani D, Knox SM, Le QT, Mochly-Rosen D. (2018) Proc Natl Acad Sci U S A. 2018 May 24. pii: 201802184. doi: 10.1073/pnas.1802184115. [PubMed]

Minimal Information About an Immuno-Peptidomics Experiment (MIAIPE).

Lill JR, van Veelen PA, Tenzer S, Admon A, Caron E, Elias J, Heck AJR, Marcilla M, Marino F, Müller M, Peters B, Purcell A, Sette A, Sturm T, Ternette N, Vizcaíno JA, Bassani-Sternberg M. (2018) Proteomics. 2018 May 23:e1800110. doi:10.1002/pmic.201800110. [PubMed]

Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics.

Yang AC, du Bois H, Olsson N, Gate D, Lehallier B, Berdnik D, Brewer KD, Bertozzi CR, Elias JE, Wyss-Coray T. (2018) J Am Chem Soc. 2018 May 18. doi:10.1021/jacs.8b03074. [PubMed]

Expression variation and covariation impair analog and enable binary signaling control.

Kovary KM, Taylor B, Zhao ML, Teruel MN. (2018) Mol Syst Biol. 2018 May 14;14(5):e7997. doi: 10.15252/msb.20177997. [PubMed]

Organizing biochemistry in space and time using prion-like self-assembly.

Jakobson CM, Jarosz DF. (2018) Curr Opin Syst Biol. 2018 Apr;8:16-24. doi: 10.1016/j.coisb.2017.11.012. Epub 2017 Dec 6. [PubMed]

Faulty replication can sting.

Crossley MP, Cimprich KA. (2018) Nature. 2018 May;557(7703):34-35. doi: 10.1038/d41586-018-02804-6. [PubMed]

MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A.

Rocha AG, Franco A, Krezel AM, Rumsey JM, Alberti JM, Knight WC, Biris N, Zacharioudakis E, Janetka JW, Baloh RH, Kitsis RN, Mochly-Rosen D, Townsend RR, Gavathiotis E, Dorn GW 2nd. (2018) Science. 2018 Apr 20;360(6386):336-341. doi: 10.1126/science.aao1785. [PubMed]

A Transcriptional Circuit Filters Oscillating Circadian Hormonal Inputs to Regulate Fat Cell Differentiation.

Bahrami-Nejad Z, Zhao ML, Tholen S, Hunerdosse D, Tkach KE, van Schie S, Chung M, Teruel MN. (2018) Cell Metab. 2018 Apr 3;27(4):854-868.e8. doi: 10.1016/j.cmet.2018.03.012. [PubMed]

Cardioprotection induced by a brief exposure to acetaldehyde:role of aldehyde dehydrogenase 2.

Ueta CB, Campos JC, Albuquerque RPE, Lima VM, Disatnik MH, Sanchez AB, Chen CH, Medeiros MHG, Yang W, Mochly-Rosen D, Ferreira JCB. (2018) Cardiovasc Res. 2018 Mar 20. doi: 10.1093/cvr/cvy070. [PubMed]