Publications

Biomolecular Condensation: A New Phase in Cancer Research.

Chakravarty AK, McGrail DJ, Lozanoski TM, Dunn BS, Shih DJH, Cirillo KM, Cetinkaya SH, Zheng WJ, Mills GB, Yi SS, Jarosz DF, Sahni N. Cancer Discov. 2022 Jul 19:OF1-OF13. doi: 10.1158/2159-8290.CD-21-1605. Online ahead of print. PMID: 35852417 [PubMed]

A cAMP Sensor Based on Ligand-Dependent Protein Stabilization.

Sidoli M, Chen LC, Lu AJ, Wandless TJ, Talbot WS. ACS Chem Biol. 2022 Jul 15. doi: 10.1021/acschembio.2c00333. Online ahead of print. PMID: 35839076 [PubMed]

Double-lariat caged morpholino oligonucleotides for optical gene silencing.

Pattanayak S., Deiters, A., and Chen, J. K. (2022) Double-lariat caged morpholino oligonucleotides for optical gene silencing. ChemRxiv doi:10.26434/chemrxiv-2022-z6shp. [ChemRxiv]

Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1.

Feng, Z., Hom, M. E., Bearrood, T. E., Rosenthal, Z. C., Fernández, D., Ondrus, A. E., Gu, Y., McCormick, A. K., Tomaske, M. G., Marshall, C. R., Kline, T., Chen, C.-H., Mochly-Rosen, D., Kuo, C. J., and Chen, J. K. (2022) Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1. Nat. Chem. Biol., online ahead of print. [PubMed]

Structure of the nutrient-sensing hub GATOR2. Nature.

Valenstein ML, Rogala KB, Lalgudi PV, Brignole EJ, Gu X, Saxton RA, Chantranupong L, Kolibus J, Quast J-P, Sabatini DM. (2022) Structure of the nutrient-sensing hub GATOR2. Nature, 607(7919):610–616. PMID: 35831510. [PubMed]

Egg-Derived Anti-SARS-CoV-2 Immunoglobulin Y (IgY) With Broad Variant Activity as Intranasal Prophylaxis Against COVID-19.

Frumkin LR, Lucas M, Scribner CL, Ortega-Heinly N, Rogers J, Yin G, Hallam TJ, Yam A, Bedard K, Begley R, Cohen CA, Badger CV, Abbasi SA, Dye JM, McMillan B, Wallach M, Bricker TL, Joshi A, Boon ACM, Pokhrel S, Kraemer BR, Lee L, Kargotich S, Agochiya M, John TS, Mochly-Rosen D. Front Immunol. 2022 Jun 1;13:899617. doi: 10.3389/fimmu.2022.899617. eCollection 2022. PMID: 35720389 [PubMed]

ALDH2 variance in disease and populations.

Chen CH, Kraemer BR, Mochly-Rosen D. Dis Model Mech. 2022 Jun 1;15(6):dmm049601. doi: 10.1242/dmm.049601. Epub 2022 Jun 24. PMID: 35749303 [PubMed]

Quantitative DNA-RNA Immunoprecipitation Sequencing with Spike-Ins.

Crossley MP, Cimprich KA. Methods Mol Biol. 2022;2528:381-410. doi: 10.1007/978-1-0716-2477-7_26. PMID: 35704206 [PubMed]

Walking a tightrope: The complex balancing act of R-loops in genome stability.

Brickner JR, Garzon JL, Cimprich KA. Mol Cell. 2022 Apr 29:S1097-2765(22)00325-2. doi: 10.1016/j.molcel.2022.04.014. Online ahead of print. PMID: 35508167 Review. [PubMed]

Azetidine-2-Carboxylic Acid-Induced Oligodendrogliopathy: Relevance to the Pathogenesis of Multiple Sclerosis.

Sobel RA, Albertelli M, Hinojoza JR, Eaton MJ, Grimes KV, Rubenstein E. J Neuropathol Exp Neurol. 2022 May 20;81(6):414-433. doi: 10.1093/jnen/nlac028. PMID: 35521963 Free PMC article. [PubMed]

A US clinical trial network is needed for the next pandemic.

Yajima R, More AF, Garvan C, Harper C, Grimes KV. Nat Med. 2022 May 31. doi: 10.1038/s41591-022-01831-1. Online ahead of print. PMID: 35641823 No abstract available. [PubMed]

Affordable IgY-based antiviral prophylaxis for resource-limited settings to address epidemic and pandemic risks.

Chen CJ, Hudson AF, Jia AS, Kunchur CR, Song AJ, Tran E, Fisher CJ, Zanchi D, Lee L, Kargotich S, Romeo M, Koperniku A, Pamnani RD, Mochly-Rosen D. J Glob Health. 2022 Feb 26;12:05009. doi: 10.7189/jogh.12.05009. eCollection 2022. PMID: 35265332 Free PMC article. [PubMed]

Alcohol Consumption, ALDH2 Polymorphism as Risk Factors for Upper Aerodigestive Tract Cancer Progression and Prognosis.

Chen CH, Wang WL, Hsu MH, Mochly-Rosen D. Life (Basel). 2022 Feb 27;12(3):348. doi: 10.3390/life12030348. PMID: 35330099 Free PMC article. Review. [PubMed]

A Selective Inhibitor of Cardiac Troponin I Phosphorylation by Delta Protein Kinase C (δPKC) as a Treatment for Ischemia-Reperfusion Injury.

Qvit N, Lin AJ, Elezaby A, Ostberg NP, Campos JC, Ferreira JCB, Mochly-Rosen D. Pharmaceuticals (Basel). 2022 Feb 22;15(3):271. doi: 10.3390/ph15030271. PMID: 35337069 Free PMC article. [PubMed]

ALDH2 Expression, Alcohol Intake, and Semen Parameters Among East Asian Men.

Greenberg DR, Bhambvani HP, Basran SS, Salazar BP, Rios LC, Li SJ, Chen CH, Mochly-Rosen D, Eisenberg ML. J Urol. 2022 Mar 28:101097JU0000000000002682. doi: 10.1097/JU.0000000000002682. Online ahead of print. PMID: 35344413 [PubMed]

CRISPR-mediated Synergistic Epigenetic and Transcriptional Control.

Dominguez AA, Chavez MG, Urke A, Gao Y, Wang L, Qi LS. CRISPR J. 2022 Mar 10. doi: 10.1089/crispr.2021.0099. Online ahead of print. PMID: 35271371 [PubMed]

Boosting the Discovery of Small Molecule Inhibitors of Glucose-6-Phosphate Dehydrogenase for the Treatment of Cancer, Infectious Diseases, and Inflammation.

Koperniku A, Garcia AA, Mochly-Rosen D. J Med Chem. 2022 Mar 3. doi: 10.1021/acs.jmedchem.1c01577. Online ahead of print. PMID: 35239352 [PubMed]

Multi-color super-resolution imaging to study human coronavirus RNA during cellular infection.

Wang J, Han M, Roy AR, Wang H, Möckl L, Zeng L, Moerner WE, Qi LS. Cell Rep Methods. 2022 Feb 28;2(2):100170. doi: 10.1016/j.crmeth.2022.100170. Epub 2022 Feb 1. PMID: 35128513 Free PMC article. [PubMed]

Dual CRISPR interference and activation for targeted reactivation of X-linked endogenous FOXP3 in human breast cancer cells.

Cui X, Zhang C, Xu Z, Wang S, Li X, Stringer-Reasor E, Bae S, Zeng L, Zhao D, Liu R, Qi LS, Wang L. Mol Cancer. 2022 Feb 7;21(1):38. doi: 10.1186/s12943-021-01472-x. PMID: 35130925 Free PMC article. [PubMed]

The use of new CRISPR tools in cardiovascular research and medicine.

Nishiga M, Liu C, Qi LS, Wu JC. Nat Rev Cardiol. 2022 Feb 10. doi: 10.1038/s41569-021-00669-3. Online ahead of print. PMID: 35145236 Review. [PubMed]

Roles of transposable elements in the regulation of mammalian transcription.

Fueyo R, Judd J, Feschotte C, Wysocka J. Nat Rev Mol Cell Biol. 2022 Feb 28. doi: 10.1038/s41580-022-00457-y. Online ahead of print. PMID: 35228718 Review. [PubMed]

Mitochondrial fusion, fission and mitophagy in cardiac diseases: challenges and therapeutic opportunities.

Scheffer DDL, Garcia AA, Lee L, Mochly-Rosen D, Ferreira JCB. Antioxid Redox Signal. 2022 Jan 19. doi: 10.1089/ars.2021.0145. Online ahead of print. PMID: 35044229 [PubMed]

Stabilization of glucose-6-phosphate dehydrogenase oligomers enhances catalytic activity and stability of clinical variants.

Garcia AA, Mathews II, Horikoshi N, Matsui T, Kaur M, Wakatsuki S, Mochly-Rosen D. J Biol Chem. 2022 Jan 19:101610. doi: 10.1016/j.jbc.2022.101610. Online ahead of print. [PubMed]

Drp1/Fis1-Dependent Pathologic Fission and Associated Damaged Extracellular Mitochondria Contribute to Macrophage Dysfunction in Endotoxin Tolerance.

Mukherjee R, Tompkins CA, Ostberg NP, Joshi AU, Massis LM, Vijayan V, Gera K, Monack D, Cornell TT, Hall MW, Mochly-Rosen D, Haileselassie B. Crit Care Med. 2022 Jan 24. doi: 10.1097/CCM.0000000000005437. Online ahead of print. PMID: 35067534 [PubMed]

Treatment-refractory ulcerative colitis responsive to indigo naturalis.

Saiki JP, Andreasson JO, Grimes KV, Frumkin LR, Sanjines E, Davidson MG, Park KT, Limketkai B. BMJ Open Gastroenterol. 2021 Dec;8(1):e000813. doi: 10.1136/bmjgast-2021-000813. PMID: 34969665 [PubMed]