Publications

ALDH2 and Cardiovascular Disease.

Chen CH, Ferreira JCB, Mochly-Rosen D. Adv Exp Med Biol. 2019;1193:53-67. doi: 10.1007/978-981-13-6260-6_3. PMID: 31368097 [PubMed - in process] [PubMed]

Site-Programmable Transposition: Shifting the Paradigm for CRISPR-Cas Systems.

Chavez M, Qi LS. Mol Cell. 2019 Jul 25;75(2):206-208. doi: 10.1016/j.molcel.2019.07.004. PMID: 31348878 [PubMed - in process] [PubMed]

Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility

Stowers RS, Shcherbina A, Israeli J, Gruber JJ, Chang J, Nam S, Rabiee A, Teruel MN, Snyder MP, Kundaje A, Chaudhuri O. Nat Biomed Eng. 2019 Jul 8. doi: 10.1038/s41551-019-0420-5. [Epub ahead of print] PMID: 31285581 [PubMed - as supplied by publisher] [PubMed]

Combinatorial control of gene function with wavelength-selective caged morpholinos

Pattanayak S, Vázquez-Maldonado LA, Deiters A, Chen JK. Methods Enzymol. 2019;624:69-88. doi: 10.1016/bs.mie.2019.04.007. Epub 2019 Apr 25. PMID: 31370936 [PubMed - in process] [PubMed]

Putting the brakes on the cell cycle: mechanisms of cellular growth arrest.

Pack LR, Daigh LH, Meyer T. Curr Opin Cell Biol. 2019 Jun 25;60:106-113. doi: 10.1016/j.ceb.2019.05.005. [Epub ahead of print] Review. [PubMed]

Small-Molecule Activators of Glucose-6-phosphate Dehydrogenase (G6PD) Bridging the Dimer Interface.

Raub AG, Hwang S, Horikoshi N, Cunningham AD, Rahighi S, Wakatsuki S, Mochly-Rosen D. ChemMedChem. 2019 Jun 11. doi: 10.1002/cmdc.201900341. [Epub ahead of print] [PubMed]

YAP-independent mechanotransduction drives breast cancer progression.

Lee JY, Chang JK, Dominguez AA, Lee HP, Nam S, Chang J, Varma S, Qi LS, West RB, Chaudhuri O. Nat Commun. 2019 Apr 23;10(1):1848. doi: 10.1038/s41467-019-09755-0. [PubMed]

The Spatiotemporal Pattern and Intensity of p53 Activation Dictates Phenotypic Diversity in p53-Driven Developmental Syndromes.

Bowen ME, McClendon J, Long HK, Sorayya A, Van Nostrand JL, Wysocka J, Attardi LD. Dev Cell. 2019 May 28. pii: S1534-5807(19)30387-9. doi: 10.1016/j.devcel.2019.05.015. [Epub ahead of print] [PubMed]

2018 ISSCR Strategic Planning: Looking to the Future.

Wysocka J, Rossant J. Stem Cell Reports. 2019 Jun 11;12(6):1183-1185. doi: 10.1016/j.stemcr.2019.05.015. [PubMed]

Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease.

Roake CM, Chen L, Chakravarthy AL, Ferrell JE Jr, Raffa GD, Artandi SE. Mol Cell. 2019 May 16;74(4):688-700.e3. doi: 10.1016/j.molcel.2019.02.033. Epub 2019 Mar 28. [PubMed]

A compact synthetic pathway rewires cancer signaling to therapeutic effector release.

Chung HK, Zou X, Bajar BT, Brand VR, Huo Y, Alcudia JF, Ferrell JE Jr, Lin MZ. Science. 2019 May 3;364(6439). pii: eaat6982. doi: 10.1126/science.aat6982. [PubMed]

Pervasive function and evidence for selection across standing genetic variation in S. cerevisiae.

Jakobson CM, She R, Jarosz DF. Nat Commun. 2019 Mar 15;10(1):1222. doi: 10.1038/s41467-019-09166-1. [PubMed]

Molecular Origins of Complex Heritability in Natural Genotype-to-Phenotype Relationships.

Jakobson CM, Jarosz DF. Cell Syst. 2019 May 22;8(5):363-379.e3. doi: 10.1016/j.cels.2019.04.002. Epub 2019 May 1. [PubMed]

Transcription-coupled changes in nuclear mobility of mammalian cis-regulatory elements.

Gu B, Swigut T, Spencley A, Bauer MR, Chung M, Meyer T, Wysocka J. 2018 Mar 2;359(6379):1050-1055. doi: 10.1126/science.aao3136. Epub 2018 Jan 25. [PubMed]

An intrinsic S/G2 checkpoint enforced by ATR.

Saldivar JC, Hamperl S, Bocek MJ, Chung M, Bass TE, Cisneros-Soberanis F, Samejima K, Xie L, Paulson JR, Earnshaw WC, Cortez D, Meyer T, Cimprich KA. Science. 2018 Aug 24;361(6404):806-810. doi: 10.1126/science.aap9346. [PubMed]

Efficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization.

Tsai TY, Collins SR, Chan CK, Hadjitheodorou A, Lam PY, Lou SS, Yang HW, Jorgensen J, Ellett F, Irimia D, Davidson MW, Fischer RS, Huttenlocher A, Meyer T, Ferrell JE Jr, Theriot JA. . Dev Cell. 2019 Apr 22;49(2):189-205.e6. doi: 10.1016/j.devcel.2019.03.025. [PubMed]

The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity.

Gan L, Seki A, Shen K, Iyer H, Han K, Hayer A, Wollman R, Ge X, Lin JR, Dey G, Talbot WS, Meyer T. Nat Cell Biol. 2019 May;21(5):614-626. doi: 10.1038/s41556-019-0321-6. Epub 2019 Apr 29. [PubMed]

Targeting mitochondrial dysfunction and oxidative stress in heart failure: challenges and opportunities.

Kiyuna LA, Prestes E Albuquerque R, Chen CH, Mochly-Rosen D, Ferreira JCB. (2018) Free Radic Biol Med. 2018 Sep 15. pii: S0891-5849(18)31130-4. doi: 10.1016/j.freeradbiomed.2018.09.019. [PubMed]

Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites.

Boucher MJ, Ghosh S, Zhang L, Lal A, Jang SW, Ju A, Zhang S, Wang X, Ralph SA, Zou J, Elias JE, Yeh E. (2018) PLoS Biol. 2018 Sep 13;16(9):e2005895. doi: 10.1371/journal.pbio.2005895. [PubMed]

Surviving in the Valley of Death: Opportunities and Challenges in Translating Academic Drug Discoveries.

Parrish MC, Tan YJ, Grimes KV, Mochly-Rosen D. (2018) Annu Rev Pharmacol Toxicol. 2018 Sep 12. doi: 10.1146/annurev-pharmtox-010818-021625. [PubMed]

Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma.

Purzner T, Purzner J, Buckstaff T, Cozza G, Gholamin S, Rusert JM, Hartl TA, Sanders J, Conley N, Ge X, Langan M, Ramaswamy V, Ellis L, Litzenburger U, Bolin S, Theruvath J, Nitta R, Qi L, Li XN, Li G, Taylor MD, Wechsler-Reya RJ, Pinna LA, Cho YJ, Fuller MT, Elias JE, Scott MP. (2018) Sci Signal. 2018 Sep 11;11(547). pii: eaau5147. doi: 10.1126/scisignal.aau5147. [PubMed]

Proteomic analysis of monolayer-integrated proteins on lipid droplets identifies amphipathic interfacial α-helical membrane anchors.

Pataki CI, Rodrigues J, Zhang L, Qian J, Efron B, Hastie T, Elias JE, Levitt M, Kopito RR. (2018) Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8172-E8180. doi: 10.1073/pnas.1807981115. [PubMed]

An intrinsic S/G2 checkpoint enforced by ATR.

Saldivar JC, Hamperl S, Bocek MJ, Chung M, Bass TE, Cisneros-Soberanis F, Samejima K, Xie L, Paulson JR, Earnshaw WC, Cortez D, Meyer T, Cimprich KA. (2018) Science. 2018 Aug 24;361(6404):806-810. doi: 10.1126/science.aap9346. PubMed PMID: 30139873. [PubMed]

Mutations, protein homeostasis, and epigenetic control of genome integrity.

Xie JL, Jarosz DF. (2018) DNA Repair (Amst). 2018 Aug 23. pii: S1568-7864(18)30169-1. doi: 10.1016/j.dnarep.2018.08.004. [PubMed]

Mortal engines: Mitochondrial bioenergetics and dysfunction in neurodegenerative diseases.

Joshi AU, Mochly-Rosen D. (2018) Pharmacol Res. 2018 Aug 23. pii: S1043-6618(18)30467-5. doi: 10.1016/j.phrs.2018.08.010. [PubMed]