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The prenylated proteome of Plasmodium falciparum reveals pathogen-specific prenylation activity and drug mechanism-of-action.

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Engineered Substrate-Specific Delta PKC Antagonists to Enhance Cardiac Therapeutics.

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Isotope-targeted glycoproteomics (IsoTaG) analysis of sialylated N- and O-glycopeptides on an Orbitrap Fusion Tribrid using azido and alkynyl sugars.

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The FaceBase Consortium: A comprehensive resource for craniofacial researchers.

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The FaceBase Consortium: A comprehensive resource for craniofacial researchers.

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Glucose-6-Phosphate Dehydrogenase Deficiency and the Need for a Novel Treatment to Prevent Kernicterus.

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The entangled ER-mitochondrial axis as a potential therapeutic strategy in neurodegeneration: A tangled duo unchained.

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GAPDH (glyceraldehyde-3-phosphate dehydrogenase) Protein-Protein Interaction Inhibitor Reveals a Non-Catalytic Role for GAPDH Oligomerization in Cell Death.

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The Prozone Effect Accounts for the Paradoxical Function of the Cdk-Binding Protein Suc1/Cks.

Ha SH, Kim SY, Ferrell JE Jr. (2016) Cell Rep. 2016 Feb 16;14(6):1408-21. [PubMed]

Waves of actin and microtubule polymerization drive microtubule-based transport and neurite growth before single axon formation.

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Host-Microbiota Interactions in the Pathogenesis of Antibiotic-Associated Diseases.

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I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs.

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Foxd3 Promotes Exit from Naive Pluripotency through Enhancer Decommissioning and Inhibits Germline Specification.

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Foxd3 Promotes Exit from Naive Pluripotency through Enhancer Decommissioning and Inhibits Germline Specification.

Respuela P, Nikolić M, Tan M, Frommolt P, Zhao Y, Wysocka J, Rada-Iglesias A. (2015) Cell Stem Cell. 2016 Jan 7;18(1):118-33. [PubMed]

Hsp90: A Global Regulator of the Genotype-to-Phenotype Map in Cancers.

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Phylogenetic Profiling for Probing the Modular Architecture of the Human Genome.

Dey G, Meyer T. (2015) Cell Syst. Aug 26;1(2):106-15. doi: 10.1016/j.cels.2015.08.006. Epub 2015 Aug 26. [PubMed]

Targeted TranscriptionalRepression in Bacteria Using CRISPR Interference (CRISPRi).

Hawkins JS, Wong S, Peters JM, Almeida R, Qi LS. (2015) Methods Mol Biol. 2015;1311:349-62.[PubMed]

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Zalatan JG, Lee ME, Almeida R, Gilbert LA, Whitehead EH, La Russa M, Tsai JC, Weissman JS, Dueber JE, Qi LS, Lim WA. Cell. 2015 Jan15;160(1-2):339-50.[PubMed]

Small molecules enhance CRISPR genome editing in pluripotent stem cells.

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Transcription factor competition allows embryonic stem cells to distinguish authentic signals from noise.

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Ginsenoside Rd attenuatesAβ25-35-induced oxidative stress and apoptosis in primary cultured hippocampalneurons

Liu JF, Yan XD, Qi LS, Li L, Hu GY, Li P, Zhao G.(2015) Chem Biol Interact. 2015 Sep 5;239:12-8.[PubMed]

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Peters JM, Silvis MR, Zhao D, Hawkins JS, Gross CA, Qi LS. (2015) Curr Opin Microbiol. 2015 Sep 9;27:121-126.[PubMed]

The New State of the Art: Cas9 for Gene Activation and Repression.

La Russa MF, Qi LS. (2015) Mol Cell Biol. 2015 Nov 15;35(22):3800-9 [PubMed]

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Liu H, Wei Z, Dominguez A, Li Y, Wang X, Qi LS. (2015) Bioinformatics. 2015 Nov 15;31(22):3676-8.[PubMed]

Calcineurin regulates the yeast synaptojanin Inp53/Sjl3 during membrane stress.

Guiney EL, Goldman AR, Elias JE, Cyert MS.(2015) Mol Biol Cell. 2015 Feb 15;26(4):769-85. [PubMed]

Reproductive Aging Drives Protein Accumulation in the Uterus and Limits Lifespan in C. elegans.

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The effect of microbial colonization on the host proteome varies by gastrointestinal location.

Lichtman JS, Alsentzer E, Jaffe M, Sprockett D, Masutani E, Ikwa E, Fragiadakis GK, Clifford D, Huang BE, Sonnenburg JL, Huang KC, Elias JE. (2015) ISME J.  Nov 17. [PubMed]

ETO family protein Mtgr1 mediates Prdm14 functions in stem cell maintenance and primordial germ cell formation.

Nady N, Gupta A, Ma Z, Swigut T, Koide A, Koide S, Wysocka J. (2015) Elife.  2015 Nov 2;4. pii: e10150. [PubMed]

Quantitative Imaging of Gut Microbiota Spatial Organization.

Earle KA, Billings G, Sigal M, Lichtman JS, Hansson GC, Elias JE, Amieva MR, Huang KC, Sonnenburg JL. (2015) Cell Host Microbe. 2015 Oct 14;18(4):478-88. [PubMed]

Enhancer Divergence and cis-Regulatory Evolution in the Human and Chimp Neural Crest.

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Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma.

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A personalized medicine approach for Asian Americans with the aldehyde dehydrogenase 2*2 variant.

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A Proteomic Strategy Identifies Lysine Methylation of Splicing Factor snRNP70 by the SETMAR Enzyme.

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Inagaki K, Koyanagi T, Berry NC, Sun L, Mochly-Rosen D. (2008) Hypertension 51(6):1565-9 [PubMed]

Comprehensive identification of PIP3-regulated PH domains from C. elegans to H. sapiens by model prediction and live imaging.

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Suspended-drop electroporation for high-throughput delivery of biomolecules into cells.

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Peng J, Wysocka J. (2008) Trends Biochem. Sci. 33(5):191-4 [PubMed]

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Gene regulation technologies in zebrafish.

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STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels.

Brandman O, Liou J, Park WS, Meyer T. (2007) Cell 131(7):1327-39 [PubMed]

Induced fit and wit: celebrating the life of Daniel E. Koshland, Jr. (1920 – 2007).

Newton AC, Mochly-Rosen D. (2007) IUBMB Life 59(12):741-3 [PubMed]

Rapid control of protein level in the apicomplexan Toxoplasma gondii.

Herm-Götz A, Agop-Nersesian C, Münter S, Grimley JS, Wandless TJ, Frischknecht F, Meissner M. (2007) Nat. Methods 4(12):1003-5 [PubMed]

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Systems biology. A clock with a flip switch.

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The roles of PKC delta and epsilon isoenzymes in the regulation of myocardial ischaemia/reperfusion injury.

Churchill EN, Mochly-Rosen D. (2007) Biochem. Soc. Trans. 35(Pt 5):1040-2 [PubMed]

Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: a personal account and progress report on transferring academic discoveries to the clinic.

Budas GR, Koyanagi T, Churchill EN, Mochly-Rosen D. (2007) Biochem. Soc. Trans. 35(Pt 5):1021-6 [PubMed]

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Budas GR, Mochly-Rosen D. (2007) Biochem. Soc. Trans. 35(Pt 5):1052-4 [PubMed]

H3K27 demethylases, at long last.

Swigut T, Wysocka J. (2007) Cell 131(1):29-32 [PubMed]

Probing ATR activation with model DNA templates.

Cimprich KA. (2007) Cell Cycle 6(19):2348-54 [PubMed]

Assessing enzyme activities using stable isotope labeling and mass spectrometry.

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Shestopalov IA, Sinha S, Chen JK. (2007) Nat. Chem. Biol. 3(10):650-1 [PubMed]

The enantioselective synthesis of phomopsin B.

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A transgenic mouse model for high content, cell cycle phenotype screening in live primary cells.

Burney RO, Lee AI, Leong DE, Jones JT, Hahn AT, Meyer T, Yao MW. (2007) Cell Cycle 6(18):2276-83 [PubMed]

A directed approach for engineering conditional protein stability using biologically silent small molecules.

Maynard-Smith LA, Chen LC, Banaszynski LA, Ooi AG, Wandless TJ. (2007) J. Biol. Chem. 282(34):24866-72 [PubMed]

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Shimohata T, Zhao H, Sung JH, Sun G, Mochly-Rosen D, Steinberg GK. (2007) J. Cereb. Blood Flow Metab. 27(8):1463-75 [PubMed]

siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptake.

Galvez T, Teruel MN, Heo WD, Jones JT, Kim ML, Liou J, Myers JW, Meyer T. (2007) Genome Biol. 8(7):R142 [PubMed]

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Stankunas K, Bayle JH, Havranek JJ, Wandless TJ, Baker D, Crabtree GR, Gestwicki JE. (2007) Chembiochem 8(10):1162-9 [PubMed]

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Ubersax JA, Ferrell JE. (2007) Nat. Rev. Mol. Cell Biol. 8(7):530-41 [PubMed]

Legal and ethical considerations in the transfusion of infected or untested autologous blood.

Brooks JP, Ferrell JE. (2007) Am. J. Clin. Pathol. 128(1):135-42 [PubMed]

The ATR pathway: fine-tuning the fork.

Paulsen RD, Cimprich KA. (2007) DNA Repair (Amst.) 6(7):953-66 [PubMed]

An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells.

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Budas GR, Churchill EN, Mochly-Rosen D. (2007) Pharmacol. Res. 55(6):523-36 [PubMed]

Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase function.

Kheifets V, Mochly-Rosen D. (2007) Pharmacol. Res. 55(6):467-76 [PubMed]

Happy birthday protein kinase C: past, present and future of a superfamily.

Battaini F, Mochly-Rosen D. (2007) Pharmacol. Res. 55(6):461-6 [PubMed]

Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion.

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Engineering small molecule specificity in nearly identical cellular environments.

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DeltaPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo.

Bright R, Steinberg GK, Mochly-Rosen D. (2007) Brain Res. 1144:146-55 [PubMed]

SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes.

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Participation of rab5, an early endosome protein, in hepatitis C virus RNA replication machinery.

Stone M, Jia S, Heo WD, Meyer T, Konan KV. (2007) J. Virol. 81(9):4551-63 [PubMed]

The structural determinants of checkpoint activation.

MacDougall CA, Byun TS, Van C, Yee MC, Cimprich KA. (2007) Genes Dev. 21(8):898-903 [PubMed]

Catch-and-release reagents for broadscale quantitative proteomics analyses.

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Rational design of a selective antagonist of epsilon protein kinase C derived from the selective allosteric agonist, pseudo-RACK peptide.

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Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane.

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Substrate competition as a source of ultrasensitivity in the inactivation of Wee1.

Kim SY, Ferrell JE. (2007) Cell 128(6):1133-45 [PubMed]

Emi2 at the crossroads: where CSF meets MPF.

Hansen DV, Pomerening JR, Summers MK, Miller JJ, Ferrell JE, Jackson PK. (2007) Cell Cycle 6(6):732-8 [PubMed]

The alliance for cellular signaling plasmid collection: a flexible resource for protein localization studies and signaling pathway analysis.

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Impaired perfusion after myocardial infarction is due to reperfusion-induced δPKC-mediated myocardial damage.

Ikeno F, Inagaki K, Rezaee M, Mochly-Rosen D. (2007) Cardiovasc. Res. 73(4):699-709 [PubMed]

Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.

Li X, Gerber SA, Rudner AD, Beausoleil SA, Haas W, Villén J, Elias JE, Gygi SP. (2007) J. Proteome Res. 6(3):1190-7 [PubMed]

Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry.

Elias JE, Gygi SP. (2007) Nat. Methods 4(3):207-14 [PubMed]

Small-molecule regulation of zebrafish gene expression.

Esengil H, Chang V, Mich JK, Chen JK. (2007) Nat. Chem. Biol. 3(3):154-5 [PubMed]

Tuning bulk electrostatics to regulate protein function.

Serber Z, Ferrell JE. (2007) Cell 128(3):441-4 [PubMed]

Peptides derived from the C2 domain of protein kinase C epsilon (epsilon PKC) modulate epsilon PKC activity and identify potential protein-protein interaction surfaces.

Brandman R, Disatnik MH, Churchill E, Mochly-Rosen D. (2007) J. Biol. Chem. 282(6):4113-23 [PubMed]

Analyzing the ATR-mediated checkpoint using Xenopus egg extracts.

Lupardus PJ, Van C, Cimprich KA. (2007) Methods 41(2):222-31 [PubMed]

A network of Rab GTPases controls phagosome maturation and is modulated by Salmonella enterica serovar Typhimurium.

Smith AC, Heo WD, Braun V, Jiang X, Macrae C, Casanova JE, Scidmore MA, Grinstein S, Meyer T, Brumell JH. (2007) J. Cell Biol. 176(3):263-8 [PubMed]

Use of a novel method to find substrates of protein kinase C delta identifies M2 pyruvate kinase.

Siwko S, Mochly-Rosen D. (2007) Int. J. Biochem. Cell Biol. 39(5):978-87 [PubMed]

Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels.

Suh BC, Inoue T, Meyer T, Hille B. (2006) Science 314(5804):1454-7 [PubMed]

PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane.

Heo WD, Inoue T, Park WS, Kim ML, Park BO, Wandless TJ, Meyer T. (2006) Science 314(5804):1458-61 [PubMed]

Identifying novel proteins recognizing histone modifications using peptide pull-down assay.

Wysocka J. (2006) Methods 40(4):339-43 [PubMed]

Monoubiquitination of proliferating cell nuclear antigen induced by stalled replication requires uncoupling of DNA polymerase and mini-chromosome maintenance helicase activities.

Chang DJ, Lupardus PJ, Cimprich KA. (2006) J. Biol. Chem. 281(43):32081-8 [PubMed]

Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2.

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A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules.

Banaszynski LA, Chen LC, Maynard-Smith LA, Ooi AG, Wandless TJ. (2006) Cell 126(5):995-1004 [PubMed]

Protein kinase C delta (deltaPKC)-annexin V interaction: a required step in deltaPKC translocation and function.

Kheifets V, Bright R, Inagaki K, Schechtman D, Mochly-Rosen D. (2006) J. Biol. Chem. 281(32):23218-26. [PubMed]

Minimizing off-target effects by using diced siRNAs for RNA interference.

Myers JW, Chi JT, Gong D, Schaner ME, Brown PO, Ferrell JE. (2006) J RNAi Gene Silencing 2(2):181-94 [PubMed]

A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling.

Wysocka J, Swigut T, Xiao H, Milne TA, Kwon SY, Landry J, Kauer M, Tackett AJ, Chait BT, Badenhorst P, Wu C, Allis CD. (2006) Nature 442(7098):86-90 [PubMed]

Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF.

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Optimization and use of peptide mass measurement accuracy in shotgun proteomics.

Haas W, Faherty BK, Gerber SA, Elias JE, Beausoleil SA, Bakalarski CE, Li X, Villén J, Gygi SP. (2006) Mol. Cell Proteomics 5(7):1326-37 [PubMed]

Mechanistic studies of the mitotic activation of Mos.

Yue J, Ferrell JE. (2006) Mol. Cell. Biol. 26(14):5300-9 [PubMed]

Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling.

Bomgarden RD, Lupardus PJ, Soni DV, Yee MC, Ford JM, Cimprich KA. (2006) EMBO J. 25(11):2605-14 [PubMed]

B-Raf and C-Raf are required for Ras-stimulated p42 MAP kinase activation in Xenopus egg extracts.

Yue J, Xiong W, Ferrell JE. (2006) Oncogene 25(23):3307-15 [PubMed]

Enhanced analysis of metastatic prostate cancer using stable isotopes and high mass accuracy instrumentation.

Everley PA, Bakalarski CE, Elias JE, Waghorne CG, Beausoleil SA, Gerber SA, Faherty BK, Zetter BR, Gygi SP. (2006) J. Proteome Res. 5(5):1224-31 [PubMed]

Epsilon protein kinase C as a potential therapeutic target for the ischemic heart.

Inagaki K, Churchill E, Mochly-Rosen D. (2006) Cardiovasc. Res. 70(2):222-30 [PubMed]

Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus.

Lupardus PJ, Cimprich KA. (2006) Mol. Biol. Cell 17(4):1559-69 [PubMed]

A noisy ‘Start’ to the cell cycle.

Ubersax JA, Ferrell JE. (2006) Mol. Syst. Biol. 2:2006.0014 [PubMed]

Investigating macromolecules inside cultured and injected cells by in-cell NMR spectroscopy.

Serber Z, Selenko P, Hänsel R, Reckel S, Löhr F, Ferrell JE, Wagner G, Dötsch V. (2006) Nat Protoc 1(6):2701-9 [PubMed]

Histone arginine methylation and its dynamic regulation.

Wysocka J, Allis CD, Coonrod S. (2006) Front. Biosci. 11:344-55 [PubMed]

Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

Sinha S, Chen JK. (2006) Nat. Chem. Biol. 2(1):29-30 [PubMed]

Conditional control of protein function.

Banaszynski LA, Wandless TJ. (2006) Chem. Biol. 13(1):11-21 [PubMed]

Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity.

Bayle JH, Grimley JS, Stankunas K, Gestwicki JE, Wandless TJ, Crabtree GR. (2006) Chem. Biol. 13(1):99-107 [PubMed]

Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaks.

Sobeck A, Stone S, Costanzo V, de Graaf B, Reuter T, de Winter J, Wallisch M, Akkari Y, Olson S, Wang W, Joenje H, Christian JL, Lupardus PJ, Cimprich KA, Gautier J, Hoatlin ME. (2006) Mol. Cell. Biol. 26(2):425-37 [PubMed]

Multisite M-phase phosphorylation of Xenopus Wee1A.

Kim SY, Song EJ, Lee KJ, Ferrell JE. (2005) Mol. Cell. Biol. 25(23):10580-90 [PubMed]

The role of protein kinase C in cerebral ischemic and reperfusion injury.

Bright R, Mochly-Rosen D. (2005) Stroke 36(12):2781-90 [PubMed]

Interlinked fast and slow positive feedback loops drive reliable cell decisions.

Brandman O, Ferrell JE, Li R, Meyer T. (2005) Science 310(5747):496-8 [PubMed]

Characterization of mouse spleen cells by subtractive proteomics.

Dieguez-Acuna FJ, Gerber SA, Kodama S, Elias JE, Beausoleil SA, Faustman D, Gygi SP. (2005) Mol. Cell Proteomics 4(10):1459-70 [PubMed]

PKC-{epsilon}-dependent survival signals in diabetic hearts.

Malhotra A, Begley R, Kang BP, Rana I, Liu J, Yang G, Mochly-Rosen D, Meggs LG. (2005) Am. J. Physiol. Heart Circ. Physiol. 289(4):H1343-50 [PubMed]

Spines and neurite branches function as geometric attractors that enhance protein kinase C action.

Craske ML, Fivaz M, Batada NN, Meyer T. (2005) J. Cell Biol. 170(7):1147-58 [PubMed]

Taking LSD 1 to a new high.

Wysocka J, Milne TA, Allis CD. (2005) Cell 122(5):654-8 [PubMed]

RSA 2004: combined basic research satellite symposium – session three: alcohol and mitochondrial metabolism: at the crossroads of life and death.

Szabo G, Hoek JB, Darley-Usmar V, Hajnoczky G, Knudsen T, Mochly-Rosen D, Zakhari S. (2005) Alcohol. Clin. Exp. Res. 29(9):1749-52 [PubMed]

Comparative evaluation of mass spectrometry platforms used in large-scale proteomics investigations.

Elias JE, Haas W, Faherty BK, Gygi SP. (2005) Nat. Methods 2(9):667-75 [PubMed]

Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations.

Pomerening JR, Kim SY, Ferrell JE. (2005) Cell 122(4):565-78 [PubMed]

A cell-permeable, activity-based probe for protein and lipid kinases.

Yee MC, Fas SC, Stohlmeyer MM, Wandless TJ, Cimprich KA. (2005) J. Biol. Chem. 280(32):29053-9 [PubMed]

Ethanol withdrawal-associated allodynia and hyperalgesia: age-dependent regulation by protein kinase C epsilon and gamma isoenzymes.

Shumilla JA, Liron T, Mochly-Rosen D, Kendig JJ, Sweitzer SM. (2005) J Pain 6(8):535-49 [PubMed]

Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulin.

Fivaz M, Meyer T. (2005) J. Cell Biol. 170(3):429-41 [PubMed]

DeltaPKC-mediated activation of epsilonPKC in ethanol-induced cardiac protection from ischemia.

Inagaki K, Mochly-Rosen D. (2005) J. Mol. Cell. Cardiol. 39(2):203-11 [PubMed]

STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx.

Liou J, Kim ML, Heo WD, Jones JT, Myers JW, Ferrell JE, Meyer T. (2005) Curr. Biol. 15(13):1235-41 [PubMed]

Reperfusion-induced translocation of δPKC to cardiac mitochondria prevents pyruvate dehydrogenase reactivation.

Churchill EN, Murriel CL, Chen CH, Mochly-Rosen D, Szweda LI. (2005) Circ. Res. 97(1):78-85 [PubMed]

Silencing gene expression with Dicer-generated siRNA pools.

Myers JW, Ferrell JE. (2005) Methods Mol. Biol. 309:93-196 [PubMed]

WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development.

Wysocka J, Swigut T, Milne TA, Dou Y, Zhang X, Burlingame AL, Roeder RG, Brivanlou AH, Allis CD. (2005) Cell 121(6):859-72 [PubMed]

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.

Dou Y, Milne TA, Tackett AJ, Smith ER, Fukuda A, Wysocka J, Allis CD, Chait BT, Hess JL, Roeder RG. (2005) Cell 121(6):873-85 [PubMed]

Protein kinase C delta cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivation.

Raval AP, Dave KR, Prado R, Katz LM, Busto R, Sick TJ, Ginsberg MD, Mochly-Rosen D, Pérez-Pinzón MA. (2005) J. Cereb. Blood Flow Metab. 25(6):730-41 [PubMed]

An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways.

Inoue T, Heo WD, Grimley JS, Wandless TJ, Meyer T. (2005) Nat. Methods 2(6):415-8 [PubMed]

Efficient chromosome capture requires a bias in the ‘search-and-capture’ process during mitotic-spindle assembly.

Wollman R, Cytrynbaum EN, Jones JT, Meyer T, Scholey JM, Mogilner A. (2005) Curr. Biol. 15(9):828-32 [PubMed]

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

Byun TS, Pacek M, Yee MC, Walter JC, Cimprich KA. (2005) Genes Dev. 19(9):1040-52 [PubMed]

Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators.

Tanaka M, Gunawan F, Terry RD, Inagaki K, Caffarelli AD, Hoyt G, Tsao PS, Mochly-Rosen D, Robbins RC. (2005) J. Thorac. Cardiovasc. Surg. 129(5):1160-7 [PubMed]

The Parkinson’s disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis.

Xu J, Zhong N, Wang H, Elias JE, Kim CY, Woldman I, Pifl C, Gygi SP, Geula C, Yankner BA. (2005) Hum. Mol. Genet. 14(9):1231-41 [PubMed]

Characterization of the FKBP.rapamycin.FRB ternary complex.

Banaszynski LA, Liu CW, Wandless TJ. (2005) J. Am. Chem. Soc. 127(13):4715-21 [PubMed]

A local coupling model and compass parameter for eukaryotic chemotaxis.

Arrieumerlou C, Meyer T. (2005) Dev. Cell 8(2):215-27 [PubMed]

Protein localization studies in the age of ‘Omics’.

O’Rourke NA, Meyer T, Chandy G. (2005) Curr Opin Chem Biol 9(1):82-7 [PubMed]

Protein kinase Cgamma mediates ethanol withdrawal hyper-responsiveness of NMDA receptor currents in spinal cord motor neurons.

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Picking a winner: new mechanistic insights into the design of effective siRNAs.

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Large-scale characterization of HeLa cell nuclear phosphoproteins.

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Exaggerated nociceptive responses on morphine withdrawal: roles of protein kinase C epsilon and gamma.

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SILVER helps assign peptides to tandem mass spectra using intensity-based scoring.

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Checkpoint adaptation; molecular mechanisms uncovered.

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State-specific monoclonal antibodies identify an intermediate state in epsilon protein kinase C activation.

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A critical intramolecular interaction for protein kinase Cε translocation.

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A novel protein activity mediates DNA binding of an ATR-ATRIP complex.

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The neural F-box protein NFB42 mediates the nuclear export of the herpes simplex virus type 1 replication initiator protein (UL9 protein) after viral infection.

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Probing the precision of the mitotic clock with a live-cell fluorescent biosensor.

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Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems.

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Intensity-based protein identification by machine learning from a library of tandem mass spectra.

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Opposing roles of delta and εPKC in cardiac ischemia and reperfusion: targeting the apoptotic machinery.

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Specific localization and timing in neuronal signal transduction mediated by protein-lipid interactions.

Fivaz M, Meyer T. (2003) Neuron 40(2):319-30 [PubMed]

An ultrasensitive Ca2+/calmodulin-dependent protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signaling.

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Opposing effects of delta- and zeta-protein kinase C isozymes on cardiac fibroblast proliferation: use of isozyme-selective inhibitors.

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A proteomics approach to understanding protein ubiquitination.

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Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII.

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PKC isozyme selective regulation of cloned human cardiac delayed slow rectifier K current.

Xiao GQ, Mochly-Rosen D, Boutjdir M. (2003) Biochem. Biophys. Res. Commun. 306(4):1019-25 [PubMed]

Overlay method for detecting protein-protein interactions.

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Glutathione S-transferase pull-down assay.

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Methods for detecting binding proteins: an introduction.

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Prevention of NMDA-induced death of cortical neurons by inhibition of protein kinase Czeta.

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A bifunctional molecule that displays context-dependent cellular activity.

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ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation.

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Enantioselective total synthesis of ustiloxin D.

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The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.

Wysocka J, Herr W. (2003) Trends Biochem. Sci. 28(6):294-304 [PubMed]

Switch-of-function mutants based on morphology classification of Ras superfamily small GTPases.

Heo WD, Meyer T. (2003) Cell 113(3):315-28 [PubMed]

Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.

Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W. (2003) Genes Dev. 17(7):896-911 [PubMed]

Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2.

Pomerening JR, Sontag ED, Ferrell JE. (2003) Nat. Cell Biol. 5(4):346-51 [PubMed]

Fragile sites: breaking up over a slowdown.

Cimprich KA. (2003) Curr. Biol. 13(6):R231-3 [PubMed]

Recombinant Dicer efficiently converts large dsRNAs into siRNAs suitable for gene silencing.

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The JNK cascade as a biochemical switch in mammalian cells: ultrasensitive and all-or-none responses.

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Cytotoxicity of pEGFP vector is due to residues encoded by multiple cloning site.

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Single cell imaging of PI3K activity and glucose transporter insertion into the plasma membrane by dual color evanescent wave microscopy.

Tengholm A, Teruel MN, Meyer T. (2003) Sci. STKE 2003(169):PL4 [PubMed]

Fluorescence imaging of signaling networks.

Meyer T, Teruel MN. (2003) Trends Cell Biol. 13(2):101-6 [PubMed]

Enforced proximity in the function of a famous scaffold.

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Epsilon PKC is required for the induction of tolerance by ischemic and NMDA-mediated preconditioning in the organotypic hippocampal slice.

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Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: the yeast proteome.

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An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication.

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A Phase II Study of Docetaxel in Patients with Relapsed and Refractory Ewing’s Tumours.

Meyer T, McTiernan A, Whelan J. (2003) Sarcoma 7(1):13-7 [PubMed]

The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins.

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Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.

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Small molecule modulation of Smoothened activity.

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A PI3-kinase signaling code for insulin-triggered insertion of glucose transporters into the plasma membrane.

Tengholm A, Meyer T. (2002) Curr. Biol. 12(21):1871-6 [PubMed]

Inactivation of the retinoblastoma protein family can bypass the HCF-1 defect in tsBN67 cell proliferation and cytokinesis.

Reilly PT, Wysocka J, Herr W. (2002) Mol. Cell. Biol. 22(19):6767-78 [PubMed]

Tissue angiotensin II during progression or ventricular hypertrophy to heart failure in hypertensive rats; differential effects on PKC epsilon and PKC beta.

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A requirement for replication in activation of the ATR-dependent DNA damage checkpoint.

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Medulloblastoma growth inhibition by hedgehog pathway blockade.

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Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts.

Jin ZQ, Zhou HZ, Zhu P, Honbo N, Mochly-Rosen D, Messing RO, Goetzl EJ, Karliner JS, Gray MO. (2002) Am. J. Physiol. Heart Circ. Physiol. 282(6):H1970-7 [PubMed]

Molecular mechanisms of CaMKII activation in neuronal plasticity.

Fink CC, Meyer T. (2002) Curr. Opin. Neurobiol. 12(3):293-9 [PubMed]

Sequential activation of individual PKC isozymes in integrin-mediated muscle cell spreading: a role for MARCKS in an integrin signaling pathway.

Disatnik MH, Boutet SC, Lee CH, Mochly-Rosen D, Rando TA. (2002) J. Cell. Sci. 115(Pt 10):2151-63 [PubMed]

Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon.

Knauf JA, Ward LS, Nikiforov YE, Nikiforova M, Puxeddu E, Medvedovic M, Liron T, Mochly-Rosen D, Fagin JA. (2002) J. Clin. Endocrinol. Metab. 87(5):2150-9 [PubMed]

Molecular dynamics characterization of the C2 domain of protein kinase Cβ.

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Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability.

Ferrell JE. (2002) Curr. Opin. Cell Biol. 14(2):140-8 [PubMed]

Dopamine-induced exocytosis of Na,K-ATPase is dependent on activation of protein kinase C-epsilon and -delta.

Ridge KM, Dada L, Lecuona E, Bertorello AM, Katz AI, Mochly-Rosen D, Sznajder JI. (2002) Mol. Biol. Cell. 13(4):1381-9 [PubMed]

Parallel single-cell monitoring of receptor-triggered membrane translocation of a calcium-sensing protein module.

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Moderate alcohol exposure protects cardiac myocytes from ischemia-reperfusion injury.

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Intracellular transport mechanisms of signal transducers.

Dorn GW, Mochly-Rosen D. (2002) Annu. Rev. Physiol. 64:407-29 [PubMed]

Activation of p42 mitogen-activated protein kinase (MAPK), but not c-Jun NH(2)-terminal kinase, induces phosphorylation and stabilization of MAPK phosphatase XCL100 in Xenopus oocytes.

Sohaskey ML, Ferrell JE. (2002) Mol. Biol. Cell 13(2):454-68 [PubMed]

Isozyme-specific inhibitors and activators of protein kinase C.

Schechtman D, Mochly-Rosen D. (2002) Meth. Enzymol. 345:470-89 [PubMed]

Multisite phosphorylation and the countdown to S phase.

Deshaies RJ, Ferrell JE. (2001) Cell 107(7):819-22 [PubMed]

Molecular transporters for peptides: delivery of a cardioprotective εPKC agonist peptide into cells and intact ischemic heart using a transport system, R(7).

Chen L, Wright LR, Chen CH, Oliver SF, Wender PA, Mochly-Rosen D. (2001) Chem. Biol. 8(12):1123-9 [PubMed]

Six steps to destruction.

Ferrell JE. (2001) Nature 414(6863):498-9 [PubMed]

Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage.

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Evidence for functional role of epsilonPKC isozyme in the regulation of cardiac Na(+) channels.

Xiao GQ, Qu Y, Sun ZQ, Mochly-Rosen D, Boutjdir M. (2001) Am. J. Physiol., Cell Physiol. 281(5):C1477-86 [PubMed]

The classical progesterone receptor associates with p42 MAPK and is involved in phosphatidylinositol 3-kinase signaling in Xenopus oocytes.

Bagowski CP, Myers JW, Ferrell JE. (2001) J. Biol. Chem. 276(40):37708-14 [PubMed]

Adaptor proteins in protein kinase C-mediated signal transduction.

Schechtman D, Mochly-Rosen D. (2001) Oncogene 20(44):6339-47 [PubMed]

Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC.

Chen L, Hahn H, Wu G, Chen CH, Liron T, Schechtman D, Cavallaro G, Banci L, Guo Y, Bolli R, Dorn GW, Mochly-Rosen D. (2001) Proc. Natl. Acad. Sci. U.S.A. 98(20):11114-9 [PubMed]

Binding specificity for RACK1 resides in the V5 region of beta II protein kinase C.

Stebbins EG, Mochly-Rosen D. (2001) J. Biol. Chem. 276(32):29644-50 [PubMed]

Bistability in the JNK cascade.

Bagowski CP, Ferrell JE. (2001) Curr. Biol. 11(15):1176-82 [PubMed]

Control of astrocyte Ca(2+) oscillations and waves by oscillating translocation and activation of protein kinase C.

Codazzi F, Teruel MN, Meyer T. (2001) Curr. Biol. 11(14):1089-97 [PubMed]

Localization, anchoring, and functions of protein kinase C isozymes in the heart.

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Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis.

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Loss of HCF-1-chromatin association precedes temperature-induced growth arrest of tsBN67 cells.

Wysocka J, Reilly PT, Herr W. (2001) Mol. Cell. Biol. 21(11):3820-9 [PubMed]

Spontaneous occurrence of an inhibitor of protein kinase C localization in a thyroid cancer cell line: role in thyroid tumorigenesis.

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Developmental and cell-cycle regulation of Caenorhabditis elegans HCF phosphorylation.

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Calcineurin inhibitors and the generalization of the presenting protein strategy.

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Arachidonic acid protects neonatal rat cardiac myocytes from ischaemic injury through epsilon protein kinase C.

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Subcellular targeting by membrane lipids.

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Opposing effects of delta and xi PKC in ethanol-induced cardioprotection.

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Bistability in cell signaling: How to make continuous processes discontinuous, and reversible processes irreversible.

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c-Jun N-terminal kinase activation in Xenopus laevis eggs and embryos. A possible non-genomic role for the JNK signaling pathway.

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Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint.

Hekmat-Nejad M, You Z, Yee MC, Newport JW, Cimprich KA. (2000) Curr. Biol. 10(24):1565-73 [PubMed]

Spatial sensing in fibroblasts mediated by 3′ phosphoinositides.

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Synthesis of flavonol derivatives as probes of biological processes.

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Evidence for functional role of epsilonPKC isozyme in the regulation of cardiac Ca(2+) channels.

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Disease attributed to Mycobacterium chelonae in South African clawed frogs (Xenopus laevis).

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Mechanistic studies of affinity modulation.

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Studies of signal transduction events using chimeras to green fluorescent protein.

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Cloning and characterization of Xenopus Rsk2, the predominant p90 Rsk isozyme in oocytes and eggs.

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Translocation and reversible localization of signaling proteins: a dynamic future for signal transduction.

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What do scaffold proteins really do?

Ferrell JE. (2000) Sci. STKE 2000(52):pe1 [PubMed]

Protein kinase C isozymes and the regulation of diverse cell responses.

Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, Messing RO. (2000) Am. J. Physiol. Lung Cell Mol. Physiol. 279(3):L429-38 [PubMed]

Molecular memory by reversible translocation of calcium/calmodulin-dependent protein kinase II.

Shen K, Teruel MN, Connor JH, Shenolikar S, Meyer T. (2000) Nat. Neurosci. 3(9):881-6 [PubMed]

Inhibition of progesterone-induced Xenopus oocyte maturation by Nm23.

Kim SY, Ferrell JE, Chae SK, Lee KJ. (2000) Cell Growth Differ. 11(9):485-90 [PubMed]

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.

Taipale J, Chen JK, Cooper MK, Wang B, Mann RK, Milenkovic L, Scott MP, Beachy PA. (2000) Nature 406(6799):1005-9 [PubMed]

Involvement of a p38 mitogen-activated protein kinase phosphatase in protecting neonatal rat cardiac myocytes from ischemia.

Mackay K, Mochly-Rosen D. (2000) J. Mol. Cell. Cardiol. 32(8):1585-8 [PubMed]

A confederacy of bunches: fundamentals and applications of a self-associating protein.

Wandless TJ. (2000) Proc. Natl. Acad. Sci. U.S.A. 97(13):6921-3 [PubMed]

Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C.

Aley KO, Messing RO, Mochly-Rosen D, Levine JD. (2000) J. Neurosci. 20(12):4680-5 [PubMed]

Cardiotrophic effects of protein kinase C epsilon: analysis by in vivo modulation of PKCepsilon translocation.

Mochly-Rosen D, Wu G, Hahn H, Osinska H, Liron T, Lorenz JN, Yatani A, Robbins J, Dorn GW. (2000) Circ. Res. 86(11):1173-9 [PubMed]

In and out of the postsynaptic region: signalling proteins on the move.

Meyer T, Shen K. (2000) Trends Cell Biol. 10(6):238-44 [PubMed]

Activation of Wee1 by p42 MAPK in vitro and in cycling xenopus egg extracts.

Walter SA, Guadagno SN, Ferrell JE. (2000) Mol. Biol. Cell 11(3):887-96 [PubMed]

Synthesis and evaluation of daunorubicin-paclitaxel dimers.

Kar AK, Braun PD, Wandless TJ. (2000) Bioorg. Med. Chem. Lett. 10(3):261-4 [PubMed]

Pharmacological regulation of network kinetics by protein kinase C localization.

Mochly-Rosen D, Kauvar LM. (2000) Semin. Immunol. 12(1):55-61 [PubMed]

Differential codes for free Ca(2+)-calmodulin signals in nucleus and cytosol.

Teruel MN, Chen W, Persechini A, Meyer T. (2000) Curr. Biol. 10(2):86-94 [PubMed]

Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion.

Raucher D, Stauffer T, Chen W, Shen K, Guo S, York JD, Sheetz MP, Meyer T. (2000) Cell 100(2):221-8 [PubMed]

The protein kinase p90 rsk as an essential mediator of cytostatic factor activity.

Bhatt RR, Ferrell JE. (1999) Science 286(5443):1362-5 [PubMed]

Distinct, constitutively active MAPK phosphatases function in Xenopus oocytes: implications for p42 MAPK regulation In vivo.

Sohaskey ML, Ferrell JE. (1999) Mol. Biol. Cell 10(11):3729-43 [PubMed]

A versatile microporation technique for the transfection of cultured CNS neurons.

Teruel MN, Blanpied TA, Shen K, Augustine GJ, Meyer T. (1999) J. Neurosci. Methods 93(1):37-48 [PubMed]

Cardioprotection from ischemia by a brief exposure to physiological levels of ethanol: role of epsilon protein kinase C.

Chen CH, Gray MO, Mochly-Rosen D. (1999) Proc. Natl. Acad. Sci. U.S.A. 96(22):12784-9 [PubMed]

Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation.

Dorn GW, Souroujon MC, Liron T, Chen CH, Gray MO, Zhou HZ, Csukai M, Wu G, Lorenz JN, Mochly-Rosen D. (1999) Proc. Natl. Acad. Sci. U.S.A. 96(22):12798-803 [PubMed]

RACK1, a protein kinase C anchoring protein, coordinates the binding of activated protein kinase C and select pleckstrin homology domains in vitro.

Rodriguez MM, Ron D, Touhara K, Chen CH, Mochly-Rosen D. (1999) Biochemistry 38(42):13787-94 [PubMed]

Xenopus oocyte maturation: new lessons from a good egg.

Ferrell JE. (1999) Bioessays 21(10):833-42 [PubMed]

Building a cellular switch: more lessons from a good egg.

Ferrell JE. (1999) Bioessays 21(10):866-70 [PubMed]

Protein kinase C-epsilon is responsible for the protection of preconditioning in rabbit cardiomyocytes.

Liu GS, Cohen MV, Mochly-Rosen D, Downey JM. (1999) J. Mol. Cell. Cardiol. 31(10):1937-48 [PubMed]

Efficient Synthesis of β,γ Dehydrovaline.

Woiwode TF, Wandless TJ. (1999) J. Org. Chem. 64:7670-7674 [PDF]

Involvement of protein kinase Cε (PKCε) in thyroid cell death. A truncated chimeric PKCε cloned from a thyroid cancer cell line protects thyroid cells from apoptosis.

Knauf JA, Elisei R, Mochly-Rosen D, Liron T, Chen XN, Gonsky R, Korenberg JR, Fagin JA. (1999) J. Biol. Chem. 274(33):23414-25 [PubMed]

Characterization of the binding and phosphorylation of cardiac calsequestrin by epsilon protein kinase C.

Rodriguez MM, Chen CH, Smith BL, Mochly-Rosen D. (1999) FEBS Lett. 454(3):240-6 [PubMed]

Identification and management of an outbreak of Flavobacterium meningosepticum infection in a colony of South African clawed frogs (Xenopus laevis).

Green SL, Bouley DM, Tolwani RJ, Waggie KS, Lifland BD, Otto GM, Ferrell JE. (1999) J. Am. Vet. Med. Assoc. 214(12):1833-8, 1792-3 [PubMed]

A stereospecific elimination to form dehydroamino acids: synthesis of the phomopsin tripeptide sidechain.

Stohlmeyer MM, Tanaka H, Wandless TJ. (1999) J. Am. Chem. Soc. 121:6100-6101 [PDF]

M phase phosphorylation of cytoplasmic dynein intermediate chain and p150(Glued).

Huang CY, Chang CP, Huang CL, Ferrell JE. (1999) J. Biol. Chem. 274(20):14262-9 [PubMed]

Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium.

Improta-Brears T, Whorton AR, Codazzi F, York JD, Meyer T, McDonnell DP. (1999) Proc. Natl. Acad. Sci. U.S.A. 96(8):4686-91 [PubMed]

Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation.

Shen K, Meyer T. (1999) Science 284(5411):162-6 [PubMed]

Pharmacologic modulation of protein kinase C isozymes: the role of RACKs and subcellular localisation.

Csukai M, Mochly-Rosen D. (1999) Pharmacol. Res. 39(4):253-9 [PubMed]

An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia.

Mackay K, Mochly-Rosen D. (1999) J. Biol. Chem. 274(10):6272-9 [PubMed]

Affinity modulation of small-molecule ligands by borrowing endogenous protein surfaces.

Briesewitz R, Ray GT, Wandless TJ, Crabtree GR. (1999) Proc. Natl. Acad. Sci. U.S.A. 96(5):1953-8 [PubMed]

Characterization of a dextran-based bifunctional calcium indicator immobilized in cells by the enzymatic addition of isoprenoid lipids.

Horne JH, Meyer T. (1999) Cell Calcium 25(1):1-7 [PubMed]

How regulated protein translocation can produce switch-like responses.

Ferrell JE. (1998) Trends Biochem. Sci. 23(12):461-5 [PubMed]

A Simple and Efficient Method for the Preparation of Hindered Alkyl-Aryl Ethers.

Woiwode TF, Rose C, Wandless TJ. (1998) J. Org. Chem. 63:9594-9596 [PDF]

Requirement for MAPK activation for normal mitotic progression in Xenopus egg extracts.

Guadagno TM, Ferrell JE. (1998) Science 282(5392):1312-5 [PubMed]

Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis.

Laudanna C, Mochly-Rosen D, Liron T, Constantin G, Butcher EC. (1998) J. Biol. Chem. 273(46):30306-15 [PubMed]

Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals.

Oancea E, Meyer T. (1998) Cell 95(3):307-18 [PubMed]

Peptide modulators of protein-protein interactions in intracellular signaling.

Souroujon MC, Mochly-Rosen D. (1998) Nat. Biotechnol. 16(10):919-24 [PubMed]

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.

Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD. (1998) Science 281(5383):1677-9 [PubMed]

CaMKIIbeta functions as an F-actin targeting module that localizes CaMKIIalpha/beta heterooligomers to dendritic spines.

Shen K, Teruel MN, Subramanian K, Meyer T. (1998) Neuron 21(3):593-606 [PubMed]

Molecular genetic approaches. II. Expression-interaction cloning.

Csukai M, Mochly-Rosen D. (1998) Methods Mol. Biol. 88:133-9 [PubMed]

Activation of epsilon protein kinase C correlates with a cardioprotective effect of regular ethanol consumption.

Miyamae M, Rodriguez MM, Camacho SA, Diamond I, Mochly-Rosen D, Figueredo VM. (1998) Proc. Natl. Acad. Sci. U.S.A. 95(14):8262-7 [PubMed]

Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt.

Kontos CD, Stauffer TP, Yang WP, York JD, Huang L, Blanar MA, Meyer T, Peters KG. (1998) Mol. Cell. Biol. 18(7):4131-40 [PubMed]

The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes.

Ferrell JE, Machleder EM. (1998) Science 280(5365):895-8 [PubMed]

Visualization of dynamic trafficking of a protein kinase C betaII/green fluorescent protein conjugate reveals differences in G protein-coupled receptor activation and desensitization.

Feng X, Zhang J, Barak LS, Meyer T, Caron MG, Hannun YA. (1998) J. Biol. Chem. 273(17):10755-62 [PubMed]

Modulating protein kinase C signal transduction.

Mochly-Rosen D, Kauvar LM. (1998) Adv. Pharmacol. 44:91-145 [PubMed]

Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells.

Stauffer TP, Ahn S, Meyer T. (1998) Curr. Biol. 8(6):343-6 [PubMed]

Green fluorescent protein (GFP)-tagged cysteine-rich domains from protein kinase C as fluorescent indicators for diacylglycerol signaling in living cells.

Oancea E, Teruel MN, Quest AF, Meyer T. (1998) J. Cell Biol. 140(3):485-98 [PubMed]

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints.

Cliby WA, Roberts CJ, Cimprich KA, Stringer CM, Lamb JR, Schreiber SL, Friend SH. (1998) EMBO J. 17(1):159-69 [PubMed]

Anchoring proteins for protein kinase C: a means for isozyme selectivity.

Mochly-Rosen D, Gordon AS. (1998) FASEB J. 12(1):35-42 [PubMed]

In vivo and in vitro characterization of the sequence requirement for oligomer formation of Ca2+/calmodulin-dependent protein kinase IIalpha.

Shen K, Meyer T. (1998) J. Neurochem. 70(1):96-104 [PubMed]

Compartmentalized IgE receptor-mediated signal transduction in living cells.

Stauffer TP, Meyer T. (1997) J. Cell Biol. 139(6):1447-54 [PubMed]

A selective epsilon-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death.

Gray MO, Karliner JS, Mochly-Rosen D. (1997) J. Biol. Chem. 272(49):30945-51 [PubMed]

Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular trafficking.

Thissen JA, Gross JM, Subramanian K, Meyer T, Casey PJ. (1997) J. Biol. Chem. 272(48):30362-70 [PubMed]

The coatomer protein beta’-COP, a selective binding protein (RACK) for protein kinase Cε.

Csukai M, Chen CH, De Matteis MA, Mochly-Rosen D. (1997) J. Biol. Chem. 272(46):29200-6 [PubMed]

Induction of a G2-phase arrest in Xenopus egg extracts by activation of p42 mitogen-activated protein kinase.

Walter SA, Guadagno TM, Ferrell JE. (1997) Mol. Biol. Cell 8(11):2157-69 [PubMed]

Electroporation-induced formation of individual calcium entry sites in the cell body and processes of adherent cells.

Teruel MN, Meyer T. (1997) Biophys. J. 73(4):1785-96 [PubMed]

Inhibition of Lyn function in mast cell activation by SH3 domain binding peptides.

Stauffer TP, Martenson CH, Rider JE, Kay BK, Meyer T. (1997) Biochemistry 36(31):9388-94 [PubMed]

How responses get more switch-like as you move down a protein kinase cascade.

Ferrell JE. (1997) Trends Biochem. Sci. 22(8):288-9 [PubMed]

Mechanistic studies of the dual phosphorylation of mitogen-activated protein kinase.

Ferrell JE, Bhatt RR. (1997) J. Biol. Chem. 272(30):19008-16 [PubMed]

Calcium-induced restructuring of nuclear envelope and endoplasmic reticulum calcium stores.

Subramanian K, Meyer T. (1997) Cell 89(6):963-71 [PubMed]

Elementary calcium-release units induced by inositol trisphosphate.

Horne JH, Meyer T. (1997) Science 276(5319):1690-3 [PubMed]

An inhibitory fragment derived from protein kinase Cε prevents enhancement of nerve growth factor responses by ethanol and phorbol esters.

Hundle B, McMahon T, Dadgar J, Chen CH, Mochly-Rosen D, Messing RO. (1997) J. Biol. Chem. 272(23):15028-35 [PubMed]

Control of action potential-induced Ca2+ signaling in the soma of hippocampal neurons by Ca2+ release from intracellular stores.

Jacobs JM, Meyer T. (1997) J. Neurosci. 17(11):4129-35 [PubMed]

C2 region-derived peptides of beta-protein kinase C regulate cardiac Ca2+ channels.

Zhang ZH, Johnson JA, Chen L, El-Sherif N, Mochly-Rosen D, Boutjdir M. (1997) Circ. Res. 80(5):720-9 [PubMed]

A role for mitogen-activated protein kinase in the spindle assembly checkpoint in XTC cells.

Wang XM, Zhai Y, Ferrell JE. (1997) J. Cell Biol. 137(2):433-43 [PubMed]

Internal trafficking and surface mobility of a functionally intact beta2-adrenergic receptor-green fluorescent protein conjugate.

Barak LS, Ferguson SS, Zhang J, Martenson C, Meyer T, Caron MG. (1997) Mol. Pharmacol. 51(2):177-84 [PubMed]

Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic beta-cells.

Yedovitzky M, Mochly-Rosen D, Johnson JA, Gray MO, Ron D, Abramovitch E, Cerasi E, Nesher R. (1997) J. Biol. Chem. 272(3):1417-20 [PubMed]

Expression-interaction cloning.

Csukai M, Mochly-Rosen D. In Methods in Molecular Biology: Protein Targeting Protocols. R.A. Clegg (ed). Humana Press, Inc., Totowa, NJ, pp 133-139, 1997.

An improved permeabilization protocol for the introduction of peptides into cardiac myocytes. Application to protein kinase C research.

Johnson JA, Gray MO, Karliner JS, Chen CH, Mochly-Rosen D. (1996) Circ. Res. 79(6):1086-99 [PubMed]

Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs.

Ferrell JE. (1996) Trends Biochem. Sci. 21(12):460-6 [PubMed]

Ethanol and signal transduction in the myocardium: implications for the detrimental and beneficial effects.

Figueredo VM, Mochly-Rosen D. In Alcohol and the Cardiovascular System. Zakhari S and Wassef M (eds). CSR, Inc., Washington, DC pp 263-277, 1996.

A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function.

Johnson JA, Gray MO, Chen CH, Mochly-Rosen D. (1996) J. Biol. Chem. 271(40):24962-6 [PubMed]

Spatial dynamics of GFP-tagged proteins investigated by local fluorescence enhancement.

Yokoe H, Meyer T. (1996) Nat. Biotechnol. 14(10):1252-6 [PubMed]

Ultrasensitivity in the mitogen-activated protein kinase cascade.

Huang CY, Ferrell JE. (1996) Proc. Natl. Acad. Sci. U.S.A. 93(19):10078-83 [PubMed]

Differential activation of protein kinase C isozymes by phorbol ester and collagen in human skin microvascular endothelial cells.

Zhou LY, Disatnik M, Herron GS, Mochly-Rosen D, Karasek MA. (1996) J. Invest. Dermatol. 107(2):248-52 [PubMed]

Reversible desensitization of inositol trisphosphate-induced calcium release provides a mechanism for repetitive calcium spikes.

Oancea E, Meyer T. (1996) J. Biol. Chem. 271(29):17253-60 [PubMed]

The HIV nef protein associates with protein kinase C theta.

Smith BL, Krushelnycky BW, Mochly-Rosen D, Berg P. (1996) J. Biol. Chem. 271(28):16753-7 [PubMed]

Signal transduction by the polymeric immunoglobulin receptor suggests a role in regulation of receptor transcytosis.

Cardone MH, Smith BL, Mennitt PA, Mochly-Rosen D, Silver RB, Mostov KE. (1996) J. Cell Biol. 133(5):997-1005 [PubMed]

Dependence of Mos-induced Cdc2 activation on MAP kinase function in a cell-free system.

Huang CY, Ferrell JE. (1996) EMBO J. 15(9):2169-73 [PubMed]

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein.

Cimprich KA, Shin TB, Keith CT, Schreiber SL. (1996) Proc. Natl. Acad. Sci. U.S.A. 93(7):2850-5 [PubMed]

SH2 domains: a question of independence.

Wandless TJ. (1996) Curr. Biol. 6(2):125-7 [PubMed]

MAP kinases in mitogenesis and development.

Ferrell JE. (1996) Curr. Top. Dev. Biol. 33:1-60 [PubMed]

Stimulus-dependent subcellular localization of activated protein kinase C; a study with acidic fibroblast growth factor and transforming growth factor-beta 1 in cardiac myocytes.

Disatnik MH, Jones SN, Mochly-Rosen D. (1995) J. Mol. Cell. Cardiol. 27(11):2473-81 [PubMed]

C2 region-derived peptides inhibit translocation and function of beta protein kinase C in vivo.

Ron D, Luo J, Mochly-Rosen D. (1995) J. Biol. Chem. 270(41):24180-7 [PubMed]

Luminal calcium regulates the inositol trisphosphate receptor of rat basophilic leukemia cells at a cytosolic site.

Horne JH, Meyer T. (1995) Biochemistry 34(39):12738-46 [PubMed]

The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor.

Brzoska PM, Chen H, Zhu Y, Levin NA, Disatnik MH, Mochly-Rosen D, Murnane JP, Christman MF. (1995) Proc. Natl. Acad. Sci. U.S.A. 92(17):7824-8 [PubMed]

Interaction of protein kinase C with RACK1, a receptor for activated C-kinase: a role in beta protein kinase C mediated signal transduction.

Mochly-Rosen D, Smith BL, Chen CH, Disatnik MH, Ron D. (1995) Biochem. Soc. Trans. 23(3):596-600 [PubMed]

Localized calcium signals in early zebrafish development.

Reinhard E, Yokoe H, Niebling KR, Allbritton NL, Kuhn MA, Meyer T. (1995) Dev. Biol. 170(1):50-61 [PubMed]

Localization of protein kinases by anchoring proteins: a theme in signal transduction.

Mochly-Rosen D. (1995) Science 268(5208):247-51 [PubMed]

Inhibition of the spontaneous rate of contraction of neonatal cardiac myocytes by protein kinase C isozymes. A putative role for the epsilon isozyme.

Johnson JA, Mochly-Rosen D. (1995) Circ. Res. 76(4):654-63 [PubMed]

Potent stimulation of SH-PTP2 phosphatase activity by simultaneous occupancy of both SH2 domains.

Pluskey S, Wandless TJ, Walsh CT, Shoelson SE. (1995) J. Biol. Chem. 270(7):2897-900 [PubMed]

An autoregulatory region in protein kinase C: the pseudoanchoring site.

Ron D, Mochly-Rosen D. (1995) Proc. Natl. Acad. Sci. U.S.A. 92(2):492-6 [PubMed]

Prolonged phorbol ester treatment down-regulates protein kinase C isozymes and increases contraction rate in neonatal cardiac myocytes.

Johnson JA, Adak S, Mochly-Rosen D. (1995) Life Sci. 57(11):1027-38 [PubMed]

Regulation of nuclear calcium concentration.

Meyer T, Allbritton NL, Oancea E. (1995) Ciba Found. Symp. 188:252-62; discussion 262-6 [PubMed]

Source of nuclear calcium signals.

Allbritton NL, Oancea E, Kuhn MA, Meyer T. (1994) Proc. Natl. Acad. Sci. U.S.A. 91(26):12458-62 [PubMed]

Agonists and antagonists of protein kinase C function, derived from its binding proteins.

Ron D, Mochly-Rosen D. (1994) J. Biol. Chem. 269(34):21395-8 [PubMed]

Distinct responses of protein kinase C isozymes to c-erbB-2 activation in SKBR-3 human breast carcinoma cells.

Disatnik MH, Winnier AR, Mochly-Rosen D, Arteaga CL. (1994) Cell Growth Differ. 5(8):873-80 [PubMed]

Developmental expression of protein kinase C subspecies in rat brain-pituitary axis.

Garcia-Navarro S, Marantz Y, Eyal R, Kalina M, Disatnik MH, Mochly-Rosen D, Ben-Menahem D, Reiss N, Naor Z. (1994) Mol. Cell. Endocrinol. 103(1-2):133-8 [PubMed]

Evidence that inactive p42 mitogen-activated protein kinase and inactive Rsk exist as a heterodimer in vivo.

Hsiao KM, Chou SY, Shih SJ, Ferrell JE. (1994) Proc. Natl. Acad. Sci. U.S.A. 91(12):5480-4 [PubMed]

Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1.

Sugimoto S, Wandless TJ, Shoelson SE, Neel BG, Walsh CT. (1994) J. Biol. Chem. 269(18):13614-22 [PubMed]

Dual role of calmodulin in autophosphorylation of multifunctional CaM kinase may underlie decoding of calcium signals.

Hanson PI, Meyer T, Stryer L, Schulman H. (1994) Neuron 12(5):943-56 [PubMed]

Phorbol myristate acetate-mediated stimulation of transcytosis and apical recycling in MDCK cells.

Cardone MH, Smith BL, Song W, Mochly-Rosen D, Mostov KE. (1994) J. Cell Biol. 124(5):717-27 [PubMed]

Localization of protein kinase C isozymes in cardiac myocytes.

Disatnik MH, Buraggi G, Mochly-Rosen D. (1994) Exp. Cell Res. 210(2):287-97 [PubMed]

Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins.

Ron D, Chen CH, Caldwell J, Jamieson L, Orr E, Mochly-Rosen D. (1994) Proc. Natl. Acad. Sci. U.S.A. 91(3):839-43 [PubMed]

Phospholipase C-gamma 1 binding to intracellular receptors for activated protein kinase C.

Disatnik MH, Hernandez-Sotomayor SM, Jones G, Carpenter G, Mochly-Rosen D. (1994) Proc. Natl. Acad. Sci. U.S.A. 91(2):559-63 [PubMed]

Controlling signal transduction with synthetic ligands.

Spencer DM, Wandless TJ, Schreiber SL, Crabtree GR. (1993) Science 262(5136):1019-24 [PubMed]

Localized calcium spikes and propagating calcium waves.

Allbritton NL, Meyer T. (1993) Cell Calcium 14(10):691-7 [PubMed]

Use of intracellular Ca2+ stores from rat basophilic leukemia cells to study the molecular mechanism leading to quantal Ca2+ release by inositol 1,4,5-trisphosphate.

Kindman LA, Meyer T. (1993) Biochemistry 32(5):1270-7 [PubMed]

Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate.

Allbritton NL, Meyer T, Stryer L. (1992) Science 258(5089):1812-5 [PubMed]

Inhibition of protein kinase C function by injection of intracellular receptors for the enzyme.

Smith BL, Mochly-Rosen D. (1992) Biochem. Biophys. Res. Commun. 188(3):1235-40 [PubMed]

Nicotinic acetylcholine receptor desensitization is regulated by activation-induced extracellular adenosine accumulation.

Pitchford S, Day JW, Gordon A, Mochly-Rosen D. (1992) J. Neurosci. 12(11):4540-4 [PubMed]

Inhibition of c-Jun DNA binding by mitogen-activated protein kinase.

Chou SY, Baichwal V, Ferrell JE. (1992) Mol. Biol. Cell 3(10):1117-30 [PubMed]

p65 fragments, homologous to the C2 region of protein kinase C, bind to the intracellular receptors for protein kinase C.

Mochly-Rosen D, Miller KG, Scheller RH, Khaner H, Lopez J, Smith BL. (1992) Biochemistry 31(35):8120-4 [PubMed]

Alcoholism: a possible G protein disorder.

Gordon AS, MOCHLY-ROSEN D, Diamond I. In G proteins, signal transduction and disease. Milligan G, Wakelam MJO (eds). Academic Press, Ltd., London, pp 191-216, 1992.

Decoding calcium signals by multifunctional CaM kinase.

Schulman H, Hanson PI, Meyer T. (1992) Cell Calcium 13(6-7):401-11 [PubMed]

Calmodulin trapping by calcium-calmodulin-dependent protein kinase.

Meyer T, Hanson PI, Stryer L, Schulman H. (1992) Science 256(5060):1199-202 [PubMed]

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity.

Liu J, Albers MW, Wandless TJ, Luan S, Alberg DG, Belshaw PJ, Cohen P, MacKintosh C, Klee CB, Schreiber SL. (1992) Biochemistry 31(16):3896-901 [PubMed]

Association of the beta isoform of protein kinase C with vimentin filaments.

Spudich A, Meyer T, Stryer L. (1992) Cell Motil. Cytoskeleton 22(4):250-6 [PubMed]

Immunophilin-ligand complexes as probes of intracellular signaling pathways.

Schreiber SL, Liu J, Albers MW, Karmacharya R, Koh E, Martin PK, Rosen MK, Standaert RF, Wandless TJ. (1991) Transplant. Proc. 23(6):2839-44 [PubMed]

Intracellular receptors for activated protein kinase C. Identification of a binding site for the enzyme.

Mochly-Rosen D, Khaner H, Lopez J, Smith BL. (1991) J. Biol. Chem. 266(23):14866-8 [PubMed]

Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin.

Michnick SW, Rosen MK, Wandless TJ, Karplus M, Schreiber SL. (1991) Science 252(5007):836-9 [PubMed]

Identification of intracellular receptor proteins for activated protein kinase C.

Mochly-Rosen D, Khaner H, Lopez J. (1991) Proc. Natl. Acad. Sci. U.S.A. 88(9):3997-4000 [PubMed]

Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs.

Ferrell JE, Wu M, Gerhart JC, Martin GS. (1991) Mol. Cell. Biol. 11(4):1965-71 [PubMed]

The identification and purification of a mammalian-like protein kinase C in the yeast Saccharomyces cerevisiae.

Simon AJ, Milner Y, Saville SP, Dvir A, Mochly-Rosen D, Orr E. (1991) Proc. Biol. Sci. 243(1307):165-71 [PubMed]

Cell signaling by second messenger waves.

Meyer T. (1991) Cell 64(4):675-8 [PubMed]

Assessing activities of blotted protein kinases.

Ferrell JE, Martin GS. (1991) Meth. Enzymol. 200:430-5 [PubMed]

G protein and alcoholism.

Gordon AS, Mochly-Rosen D, Diamond I. In Dysfunction of G-protein linked cascades in cellular pathology. Milligan G and Wakelam MJO (eds). Academic Press, 1991.

The role of adenosine and adenosine transport in ethanol-induced cellular tolerance and dependence. Possible biologic and genetic markers of alcoholism.

Diamond I, Nagy L, Mochly-Rosen D, Gordon A. (1991) Ann. N. Y. Acad. Sci. 625:473-87 [PubMed]

Calcium spiking.

Meyer T, Stryer L. (1991) Annu Rev Biophys Biophys Chem 20:153-74 [PubMed]

GTP-binding proteins are restricted to signal transduction sites.

Mochly-Rosen D, Gordon AS. (1990) Biochem. Biophys. Res. Commun. 173(1):388-95 [PubMed]

Probing immunosuppressant action with a nonnatural immunophilin ligand.

Bierer BE, Somers PK, Wandless TJ, Burakoff SJ, Schreiber SL. (1990) Science 250(4980):556-9 [PubMed]

Reduced adenosine receptor activation in alcoholism: implications for alcohol withdrawal seizures.

Diamond I, Mochly-Rosen D, Gordon AS. In Alcohol and seizures: basic mechanisms and clinical concepts. Porter R, Mattson R, Kramer J and Diamond I (eds). FA Davis, Philadelphia, pp 79-86, 1990.

A protein kinase C isozyme is translocated to cytoskeletal elements on activation.

Mochly-Rosen D, Henrich CJ, Cheever L, Khaner H, Simpson PC. (1990) Cell Regul. 1(9):693-706 [PubMed]

Intracellular localization of pp60c-src in human platelets.

Ferrell JE, Noble JA, Martin GS, Jacques YV, Bainton DF. (1990) Oncogene 5(7):1033-6 [PubMed]

Identification of a 42-kilodalton phosphotyrosyl protein as a serine(threonine) protein kinase by renaturation.

Ferrell JE, Martin GS. (1990) Mol. Cell. Biol. 10(6):3020-6 [PubMed]

Transient calcium release induced by successive increments of inositol 1,4,5-trisphosphate.

Meyer T, Stryer L. (1990) Proc. Natl. Acad. Sci. U.S.A. 87(10):3841-5 [PubMed]

Kinetics of calcium channel opening by inositol 1,4,5-trisphosphate.

Meyer T, Wensel T, Stryer L. (1990) Biochemistry 29(1):32-7 [PubMed]

Chronic ethanol-induced heterologous desensitization is mediated by changes in adenosine transport.

Gordon AS, Nagy L, Mochly-Rosen D, Diamond I. (1990) Biochem. Soc. Symp. 56:117-36 [PubMed]