Illustration by Layla Lang
Illustration by Layla Lang
Illustration by Layla Lang
Illustration by Layla Lang
Illustration by Layla Lang
Illustration by Layla Lang
About

The Department

The Department of Chemical and Systems Biology explores the molecular mechanisms that underlie cellular function and contribute to human disease. Our laboratories emphasize interdisciplinary research that spans the biomedical sciences, including signal transduction, cell cycle regulation, chromatin remodeling, protein homeostasis, metabolism, and cell differentiation. By integrating genetic technologies, biochemical and chemical tools, quantitative measurements, and computational modeling, we strive to deconstruct these complex biological systems, predict emergent behaviors, and translate these discoveries into new medical therapies.

Welcome to CSB!

The Chemical and Systems Biology Graduate Program trains students to explore the function of complex biological systems at a quantitative and molecular level. Research in our laboratories combines state-of-the-art approaches from chemistry, biochemistry, cell biology, genomics, computational modeling, and other disciplines to understand cellular and organismal physiology, predict emergent behaviors, and translate these discoveries into new technologies and therapies. Our faculty members are internationally renowned scientists who foster an innovative and collaborative research environment, and alumni from our home program are leaders in academics, biotech, and science policy.

About

Postdoctoral Program

Postdoctoral fellows are an integral part of the Chemical and Systems Biology community, playing active roles in its research and training activities. Fellows join the Chemical and Systems Biology Postdoctoral Program through individual laboratories, and interested applicants should contact faculty members directly.

Explore The Labs

 
James K. Chen Karlene Cimprich Joshua Elias James E. Ferrell, Jr. Kevin Grimes Daniel F. Jarosz Tobias Meyer Daria Mochly-Rosen Stanley Qi Mary Teruel Thomas J. Wandless Joanna Wysocka
Chen Lab

Chen Lab


Research Focus

Developmental signaling pathways and their roles in embryonic patterning and oncogenesis; zebrafish models of tissue patterning and regeneration; synthetic chemistry and chemical biology.


Publication

TBX16 Regulates Hox Gene Activation In Mesodermal Progenitor Cells.


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Cimprich Lab

Cimprich Lab


Research Focus

Genome stability pathways and their roles in cancer and other human diseases; DNA damage response pathways and DNA replication; the interface between RNA processing and transcription with genome stability.


Publication

Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses.


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Elias Lab

Elias Lab


Research Focus

New mass spectrometry-based experimental and computational tools that advance the field of proteomics; applying them to important diseases including cancer, heart disease and autoimmunity.


Publication

Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens.


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Ferrell, Jr. Lab

Ferrell Lab


Research Focus

Cell cycle regulation, especially M-phase regulation, in Xenopus embryos and mammalian cell lines; systems biology of signal transduction pathways.


Publication

Thresholds And Ultrasensitivity From Negative Cooperativity.


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Grimes Lab

SPARK


Research Focus

Translation of promising research discoveries into novel therapeutics and diagnostics; discovery and development of new drugs, biologics, and diagnostics; repurposing existing drugs against new targets for new clinical indications.


Publication

A Practical Guide to Drug Development in Academia: the SPARK Approach.


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Jarosz Lab

Jarosz Lab


Research Focus

Protein conformational switches in evolution, disease, and development; molecular mechanisms driving mutational robustness in pathogens and cancer in complex cellular systems; chemical biology, cell signaling, and quantitative genetics.


Publication

Intrinsically Disordered Proteins Drive Emergence And Inheritance Of Biological Traits.


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Meyer Lab

Meyer Lab


Research Focus

Ca2+, lipid second messenger and small GTPase signaling pathways; Control of cell polarity, chemotaxis, and collective migration as well as cell proliferation and differentiation decisions.


Publication

Irreversible APC(Cdh1) Inactivation Underlies the Point of No Return for Cell-Cycle Entry.


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Mochly-Rosen Lab

Mochly-Rosen Lab


Research Focus

Protein kinase C signaling in normal & disease states; mitochondrial function and dynamics in normal & disease states; oxidative stress and aldehydic load; protein-protein interaction; drug discovery.


Publication

Engineered Substrate-Specific Delta PKC Antagonists to Enhance Cardiac Therapeutics.


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Qi Lab

Qi Lab


Research Focus

Tool development for genome engineering; Gene regulatory network of cell fate decisions; Cancer immunotherapy.


Publication

Genetic interaction mapping in mammalian cells using CRISPR interference.


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Teruel Lab

Teruel Lab


Research Focus

Uncovering the molecular mechanisms controlling cell differentiation and its critical role in diabetes, obesity, and cancer; understanding how cell signaling and chromatin interact to decide cell fate.


Publication

Controlling low rates of cell differentiation through noise and ultrahigh feedback.


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Wandless Lab

Wandless Lab


Research Focus

Cellular mechanisms responsible for protein quality control surveillance and degradation; invention of new technologies to enable biomedical research; synthetic chemistry and chemical biology.


Publication

A method to rapidly create protein aggregates in living cells.


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Wysocka Lab

Wysocka Lab


Research Focus

Epigenetic regulation of development; cis-regulatory elements; chromatin modification and remodeling; stem cell self-renewal and differentiation; neural crest and formation of the human face.


Publication

Ever-Changing Landscapes: Transcriptional Enhancers In Development And Evolution.


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