Developmental signaling pathways and their roles in embryonic patterning and oncogenesis; zebrafish models of tissue patterning and regeneration; synthetic chemistry and chemical biology.
Genome stability pathways and their roles in cancer and other human diseases; DNA damage response pathways and DNA replication; the interface between RNA processing and transcription with genome stability.
New mass spectrometry-based experimental and computational tools that advance the field of proteomics; applying them to important diseases including cancer, heart disease and autoimmunity.
Cell cycle regulation, especially M-phase regulation, in Xenopus embryos and mammalian cell lines; systems biology of signal transduction pathways.
Translation of promising research discoveries into novel therapeutics and diagnostics; discovery and development of new drugs, biologics, and diagnostics; repurposing existing drugs against new targets for new clinical indications; developing novel therapeutics and diagnostics for neglected global health problems.
Protein conformational switches in evolution, disease, and development; molecular mechanisms driving robustness in complex cellular systems; chemical biology, cell signaling, and quantitative genetics
Ca2+, lipid second messenger and small GTPase signaling pathways; Control of cell polarity, chemotaxis, and collective migration as well as cell proliferation and differentiation decisions
Protein kinase C signaling in normal & disease states; mitochondrial function and dynamics in normal & disease states; oxidative stress and aldehydic load; protein-protein interaction; drug discovery
Technology development for genome editing and gene regulation; Epigenetic regulation of cell fate; Synthetic circuits for cell reprogramming
Uncovering the molecular mechanisms controlling cell differentiation and its critical role in diabetes, obesity, and cancer; understanding how cell signaling and chromatin interact to decide cell fate
Cellular mechanisms responsible for protein quality control surveillance and degradation; invention of new technologies to enable biomedical research; synthetic chemistry and chemical biology
Epigenetic regulation of development; cis-regulatory elements; chromatin modification and remodeling; stem cell self-renewal and differentiation; neural crest and formation of the human face
Professor, Department of Chemistry
Cell surface interactions that contribute to human health and disease with specific projects in the areas of cancer, inflammation and bacterial infection. Use techniques of organic synthesis, genetics, and biochemistry as tools to study and manipulate complex cellular processes. Much of our research involves cell surface oligosaccharides, biopolymers that contribute to cell surface recognition and cell-cell communication.
Professor, Department of Pathology
Proteolytic pathways involved in cancer, inflammation and infectious disease. Use of small molecules to image protease activity, design of protease inhibitors and therapeutic applications.
Associate Professor, Department of Bioengineering
Building computational models of complex biological processes to guide an experimental program and accelerate discovery.
Associate Professor, Department of Chemistry
Voltage-gated ion channel trafficking and regulation; influence of glial cells on channel expression; molecular design, chemical synthesis, and homology modeling; electrophysiology and imaging.
Professor, Molecular and Cellular Physiology
Structural basis of G protein-coupled receptor signal transduction
Assistant Professor, Departments of Neurobiology and Bioengineering
Protein engineering applied to sensing or controlling cell biology, including fluorescent proteins, optogenetic actuators, synthetic signaling nodes, and drug-controlled production switches.
Professor, Department of Medicine
Hematopoiesis, trafficking of nucleolar proteins, regulation of ribosomal RNA synthesis, hematopoietic stem cells, leukemogenesis, development of novel therapeutics for leukemias.
Associate Professor, Department of Biology
Cell cycle control, maternal to zygotic transition, cell size control, MAPK signaling, systems and quantitative biology
Associate Professor, Department of Biochemistry
Chromosome segregation, chromosome structure, centromeres and kinetochores, chromatin dynamics and remodeling, noncoding RNA, cell division, cell size control, microscopy.
Professor, Department of Chemistry
Synthesis, catalysis, drug design, computer modeling, chemical biology, drug delivery, cancer, resistant disease, HIV/AIDS eradication, Alzheimer’s disease, immunotherapy
Associate Professor, Department of Pathology
Direct lineage reprogramming into neural cell types; Pluripotent stem cells; Human models of disease and gene function; Molecular mechanisms and clinical applications of reprogramming techniques