The Department of Chemical and Systems Biology Presents Cutting Lecture Series: Oded Rechavi PhD
Professor Oded Rechavi
Department of Neurobiology
Wise Faculty of Life Sciences & Sagol School of Neuroscience
Tel Aviv University, Tel Aviv, Israel
Friday, December 9, 2022
12:30 PM – 1:30 PM (Pacific Time)
Munzer Auditorium
Talk Title: “Transgenerational small RNA inheritance in worms”
Abstract: In C. elegans nematodes, dedicated machinery enables transmission of small RNAs which regulate gene expression across multiple generations, independently of changes to the DNA sequence. Different environmental challenges, including exposure to starvation, genomic parasites, bacterial pathogens, and heat stress generate heritable small RNA responses, that in certain cases can be adaptive. Recently we have also shown that even neuronal processes can produce small RNA-mediated heritable responses, and that the decisions that the progeny makes are affected by whether their ancestors experienced stress or not. I will discuss the underlying mechanisms, and the potential of small RNA inheritance to affect the worms’ fate. Lastly, I will examine how these new findings might affect our view of the process of evolution and the limits of inheritance and provide evidence that transgenerational inheritance of small RNAs is possible even in other, very different organisms.