JOIN US! CSB Cutting Lecture Series: Joseph Yeeles, PhD, Friday, February 13, 12:30 PM, LKSC-LK120!
The Department of Chemical and Systems Biology Presents
Cutting Lecture Series
Joseph Yeeles, PhD
MRC Investigator
Protein & Nucleic Acid Chemistry Division
MRC Laboratory of Molecular Biology, Cambridge
Friday, February 13, 2026
12:30 PM – 1:30 PM (Pacific Time)
LKSC – LK120
Talk Title: “Setting the Speed of DNA Replication: From Helicase Activation to Fork Rate Regulation”
Talk Abstract: My laboratory seeks to understand the structures and mechanisms of the replisome, the multi-protein molecular assembly that performs chromosome replication. Replisome assembly occurs at thousands of sites throughout the human genome called origins. This process involves the assembly and activation of the replicative CMG helicase. Once activated, additional components interface with CMG to form replisomes that typically replicate DNA at ~1-2 kb minute.
During my talk I will describe our recent unpublished work on the mechanisms of CMG activation, replication fork rate control and fork restart.