CSB Special Seminar: Thanos Halazonetis, DDS, PhD, Monday, March 18, 12:30 pm, Munzer!
The Department of Chemical and Systems Biology Presents
Special Seminar
Thanos Halazonetis, DDS, PhD
Professor, Department of Molecular and Cellular Biology
University of Geneva
Monday, March 18, 2024
12:30 PM – 1:30 PM (Pacific Time)
Munzer Auditorium
Talk Title: “DNA Replication in Cancer and Normal Cells”
Abstract: Cancer cells are characterized by DNA replication stress. In the first part of the seminar, I will describe how tramscription-replication conflicts are sensed by PARP1 and how this function of PARP1 is responsible for the synthetic lethality of PARP inhibitors with homologous recombination deficiencies. In the second part of the seminar, I will describe the mapping of DNA replication origins in mouse and human cells and how specific transcription factor binding sites are required for origin firing in human cells.