CSB Special Seminar: Richard Payne, PhD, Thursday, December 12, 2024, Munzer!
The Department of Chemical and Systems Biology Presents
Special Seminar
Professor Richard J. Payne
School of Chemistry, The University of Sydney, NSW 2006, Australia and ARC, Centre of Excellence for Innovations in Peptide and Protein Science
Thursday, December 12, 2024
1:30 PM – 2:30 PM (Pacific Time)
Munzer Auditorium
Talk Title: “New Technologies for the Synthesis, Semi-Synthesis and Biosynthesis of Bioactive Peptides and Proteins”
Talk Abstract: The renaissance in the use of peptides and proteins as therapeutic agents has led to significant demand for new technologies to rapidly and efficiently access these biomolecules, especially those bearing tailor-made modifications to maximize specificity and activity, or to probe biological function (e.g. through incorporation of post-translational modifications, fluorophores and/or imaging reagents).1 We have recently developed a number of synthetic and semi-synthetic technologies that enable efficient production of peptides and proteins with homogeneous modifications at pre-determined sites.2,3 This talk will highlight the utility of these technologies for: (1) generating APIs and peptide drug leads under continuous flow conditions,3 and (2) generating proteins with site-specific and homogeneous post-translational modifications.4-7 The talk will conclude with our recent efforts to employ mRNA display methods with genetic reprogramming to generate high affinity cyclic peptides for a range of therapeutic targets.8-10
References
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- Kulkarni et al. Nature Protocols, 2019, 14, 2229.
- Kambanis et al. J. Am. Chem. Soc.2024, 146, 22027
- Premdjee et al. J. Am. Chem. Soc.2021, 143, 5336
- Kulkarni et al. Angew. Chem. Int. Ed. 2022, 61, e202200163
- Dowman et al. Nature Commun. 2022, 13, 6885.
- Harrison et al. Nature Rev. Chem. 2023, 7, 383
- Johansen-Leete et al. J. Am. Chem. Soc. 2020, 142, 9141
- Johansen-Leete et al. Chem. Sci. 2022, 13, 3826
- A. Norman et al. ACS Cent. Sci. 2021, 7, 1001