The SPARK team, including professors Daria Mochly-Rosen and Kevin Grimes, are happy to announce A Practical Guide to Drug Development in Academia: the SPARK Approach was recently published through SpringerBriefs. The book serves as a general introduction to academics new to drug discovery or translational research.
Read More »Have you heard the news? Stanford has been awarded a $11.4 million, 5 year grant from the National Centers for Systems Biology to fund the launch of the new Center for Collective Cell Decisions, co-directed by our own Chemical & Systems Biology Professors James Ferrell and Tobias Meyer.
Read More »The recent publication from the lab of Tobias Meyer, The Proliferation-Quiescence Decision Is Controlled by a Bifurcation in CDK2 Activity at Mitotic Exit, has been featured and reviewed by Elizabeth McKenna at Cancer Discovery.
Read More »Chemical and Systems Biology’s own Dr. Josh Elias has been awarded a prestigious 2013 Keck Medical Research Award from the Keck Foundation for his proposed work with Mass Spectrometry-based peptide analysis and sequencing to search in a new direction for the diagnosis and treatment of cancer.
Read More »CSB Graduate Students Jeremy Chang, Claudia Choi, and Josh Lichtman have had their recent publications show up on two major research blogs recently, Scope and ASBMB Today.
Read More »Winners of the best poster, best paper, and best talk awards at the Annual Chemical and Systems Biology Departmental Retreat are shown here with Joan Mansour, who has generously provided funds for the cash awards as well as a wonderful celebratory dinner.
Read More »Mitosis is one of the most dramatic events in cell biology and the transition from interphase to mitosis is temporally abrupt, all-or-none in character, and irreversible. Mitosis is triggered by the activation of Cdk1-cyclin B1 and its abrupt translocation from the cytoplasm to the nucleus.
Read More »The AAA+ ATPase motor cytoplasmic dynein regulates a diverse range of cellular functions, including mitotic spindle assembly, organelle trafficking, and ciliary and axonal transport. Since the dynamics of these processes are much faster than the action of reverse-genetic technologies, small-molecule modulators are essential tools for studying dynein-dependent biology. In the Apr. 5 issue of Nature, Firestone et al. reports the first chemical inhibitors of this minus-end-directed microtubule motor, which emerged from a high-throughput screen for Hedgehog pathway inhibitors. The benzoyl dihydroquinazolinone derivatives, collectively named “ciliobrevins” for their effects on primary cilia length, selectively inhibit cytoplasmic dynein 1 and 2, as demonstrated by their cellular phenotypes and actions on dynein function in vitro.
Read More »The Damon Runyon-Rachleff Innovation Award is designed to provide support for the next generation of exceptionally creative thinkers with “high risk/high reward” ideas that have the potential to significantly impact our understanding of and/or approaches to the prevention, diagnosis or treatment of cancer.
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