Hee Won Yang, Mingyu Chung, Takamasa Kudo, and Tobias Meyer featured on the cover of Nature
The recent publication of “Competing memories of mitogen and p53 signalling control cell-cycle entry” by Hee Won Yang, Mingyu Chung, Takamasa Kudo, and Tobias Meyer was featured on the cover of Nature on September 21, 2017.
To read the original Nature cover article, please click here.
To read the original publication, please click here. A summary of the paper is included below:
After the completion of cell division, daughter cells decide to either enter the next cell cycle or exit to a quiescent state. However, it was unknown when and how the selection between proliferation and quiescence is controlled. Yang and colleagues in the Meyer lab have revealed that mitogen and stress signaling compete even from mother cells to regulate cell-cycle entry in daughter cells. Mother cells transmit cyclin D1 mRNA and p53 protein to daughter cells. Synthesized cyclin D1 and p53-regulated p21 in daughter cells then regulate cell-cycle entry in an ultrasensitive manner. This control system selectively promotes proliferation of daughter cells, which have experienced lower stress and higher mitogen signaling in mother cells.
Congratulations to Hee Won, Mingyu, Takamasa, and Dr. Meyer!