The Department of Chemical and Systems Biology explores the molecular mechanisms that underlie cellular function and contribute to human disease. Our laboratories emphasize interdisciplinary research that spans the biomedical sciences, including signal transduction, cell cycle regulation, chromatin remodeling, protein homeostasis, metabolism, and cell differentiation. By integrating genetic technologies, biochemical and chemical tools, quantitative measurements, and computational modeling, we strive to deconstruct these complex biological systems, predict emergent behaviors, and translate these discoveries into new medical therapies.
How cells make the decision to divide is a fundamental process in biology, and when this decision process is perturbed cancer or developmental diseases can occur. It was previously thought that the presence or absence of external growth factors or Read More »