CSB Department Chair:
James Chen, Ph.D.
The Department of Chemical and Systems Biology explores the molecular mechanisms that underlie cellular function and contribute to human disease. Our laboratories emphasize interdisciplinary research that spans the biomedical sciences, including signal transduction, cell cycle regulation, chromatin remodeling, protein homeostasis, metabolism, and cell differentiation. By integrating genetic technologies, biochemical and chemical tools, quantitative measurements, and computational modeling, we strive to deconstruct these complex biological systems, predict emergent behaviors, and translate these discoveries into new medical therapies.
Researchers have found nearly 50 helpful prions in yeast and comparable proteins in humans, suggesting that this dreaded protein type can boost survival and plays a role in evolution. Prion proteins, best known as the agents of deadly brain disorders Read More »