The Department of Chemical and Systems Biology Presents

Jon Clardy, Ph.D.
Hsien Wu & Daisy Yen Wu Professor of Biological Chemistry
Harvard University

Friday, May 6, 2022
12:30 PM – 1:30 PM (Pacific Time)

Munzer Auditorium (In-person)

Zoom Meeting ID: 954 6555 8559
Password: 592472

Talk Title: “Lipid Immunogens from the Gut Microbiota”

Abstract: Numerous studies show robust correlations between the composition of the human gut microbiome and the states of human hosts. Some bacterial taxa/metabolites are associated with disease, others with health, but there are few descriptions of the molecular mechanisms underlying these outcomes. This talk will address homeostatic immunity and two bacteria that are associated with it: Akkermansia muciniphila and Muribaculum intestinale (or S24-7). One of these strains, S. muciniphila, is highlighted in numerous studies, the other is rarely mentioned. They were both identified as significant outliers in a large-scale screen to identify inducers of adaptive immune responses during homeostasis. Bioassay-guided fractionation has identified two relatively simple lipids, one from each, that appear to be the relevant immune modulators. Their structures, biosyntheses, synthesis, and mechanism of action will be presented.

Reading Material:

1. Henke MT, Kenny DJ, Cassilly CD, Vlamakis H, Xavier RJ, Clardy J.
   Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn’s disease, produces an inflammatory polysaccharide.
   Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12672-12677. doi: 10.1073/pnas.1904099116. Epub 2019 Jun 10. PMID: 31182571; PMCID: PMC6601261.
2. Szamosvári D, Bae M, Bang S, Tusi BK, Cassilly CD, Park SM, Graham DB, Xavier RJ, Clardy J.
   Lyme Disease, Borrelia burgdorferi, and Lipid Immunogens. J Am Chem Soc. 2022 Feb 16;144(6):2474-2478.
   doi: 10.1021/jacs.1c12202. Epub 2022 Feb 7. PMID: 35129341.
   

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