Macrocyclization of Broad-Spectrum Kinase Inhibitor Bosutinib Leads to Potent and Selective Quinoline-Based HIPK4 Inhibitor AZ137.
Zerva A, Raig ND, Zhuang Z, Krämer A, Dopfer J, Togashi RK, Schwalm MP, Elson L, Frischkorn JM, Berger BT, Müller S, Chen JK, Knapp S, Hanke T. J Med Chem. 2026 Sep 10;69(17):20616-20638. doi: 10.1021/acs.jmedchem.6c01320. PMID: 42720483 Free PMC article. [PubMed]