Inhibitors supercharge kinase turnover through native proteolytic circuits.
Scholes NS, Bertoni M, Comajuncosa-Creus A, Kladnik K, Guo X, Frommelt F, Hinterndorfer M, Razumkov H, Prokofeva P, Schwalm MP, Born F, Roehm S, Imrichova H, Santini BL, Barone E, Schätz C, Muñoz I Ordoño M, Lechner S, Rukavina A, Serrano I, Abele M, Koren A, Kubicek S, Knapp S, Gray NS, Superti-Furga G, Kuster B, Shi Y, Aloy P, Winter GE. Nature. 2026 Jan;649(8098):1032-1041. doi: 10.1038/s41586-025-09763-9. Epub 2025 Nov 26. PMID: 41299171; PMCID: PMC12823440. [PubMed]