Publications

Reactivation of the pluripotency program precedes formation of the cranial neural crest.

Zalc A, Sinha R, Gulati GS, Wesche DJ, Daszczuk P, Swigut T, Weissman IL, Wysocka J. Science. 2021 Feb 5;371(6529):eabb4776. doi: 10.1126/science.abb4776. PMID: 33542111 [PubMed]

Long-range structural defects by pathogenic mutations in most severe glucose-6-phosphate dehydrogenase deficiency.

Horikoshi N, Hwang S, Gati C, Matsui T, Castillo-Orellana C, Raub AG, Garcia AA, Jabbarpour F, Batyuk A, Broweleit J, Xiang X, Chiang A, Broweleit R, Vöhringer-Martinez E, Mochly-Rosen D, Wakatsuki S. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):e2022790118. doi: 10.1073/pnas.2022790118. PMID: 33468660 [PubMed]

Restoring metabolism of myeloid cells reverses cognitive decline in ageing.

Minhas PS, Latif-Hernandez A, McReynolds MR, Durairaj AS, Wang Q, Rubin A, Joshi AU, He JQ, Gauba E, Liu L, Wang C, Linde M, Sugiura Y, Moon PK, Majeti R, Suematsu M, Mochly-Rosen D, Weissman IL, Longo FM, Rabinowitz JD, Andreasson KI. Nature. 2021 Feb;590(7844):122-128. doi: 10.1038/s41586-020-03160-0. Epub 2021 Jan 20. PMID: 33473210 [PubMed]

ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: a multi-omics analysis.

Hu YF, Wu CH, Lai TC, Chang YC, Hwang MJ, Chang TY, Weng CH, Chang PM, Chen CH, Mochly-Rosen D, Huang CF, Chen SA. Biochim Biophys Acta Mol Basis Dis. 2021 Jan 27:166088. doi: 10.1016/j.bbadis.2021.166088. Epub ahead of print. PMID: 33515676. [PubMed]

The nucleus serves as the pacemaker for the cell cycle.

Afanzar O, Buss GK, Stearns T, Ferrell JE Jr. Elife. 2020 Dec 7;9:e59989. doi: 10.7554/eLife.59989. PMID: 33284106 Free PMC article. [PubMed]

Bistable, Biphasic Regulation of PP2A-B55 Accounts for the Dynamics of Mitotic Substrate Phosphorylation.

Kamenz J, Gelens L, Ferrell JE Jr. Curr Biol. 2020 Dec 19:S0960-9822(20)31771-1. doi: 10.1016/j.cub.2020.11.058. Online ahead of print. PMID: 33357450 [PubMed]

Regenerating Urethral Striated Muscle by CRISPRi/dCas9-KRAB-Mediated Myostatin Silencing for Obesity-Associated Stress Urinary Incontinence.

Yuan H, Ruan Y, Tan Y, Reed-Maldonado AB, Chen Y, Zhao D, Wang Z, Zhou F, Peng D, Banie L, Wang G, Liu J, Lin G, Qi LS, Lue TF. CRISPR J. 2020 Dec;3(6):562-572. doi: 10.1089/crispr.2020.0077. PMID: 33346712 [PubMed]

Why Is the GFR So High? Implications for the Treatment of Kidney Failure.

Clin J Am Soc Nephrol. 2020 Dec 10:CJN.14300920. doi: 10.2215/CJN.14300920. Online ahead of print. PMID: 33303581 Review. [PubMed]

Insights into the genetic architecture of the human face.

White JD, Indencleef K, Naqvi S, Eller RJ, Hoskens H, Roosenboom J, Lee MK, Li J, Mohammed J, Richmond S, Quillen EE, Norton HL, Feingold E, Swigut T, Marazita ML, Peeters H, Hens G, Shaffer JR, Wysocka J, Walsh S, Weinberg SM, Shriver MD, Claes P. Nat Genet. 2020 Dec 7. doi: 10.1038/s41588-020-00741-7. Online ahead of print. PMID: 33288918 [PubMed]

Identification of cell context-dependent YAP-associated proteins reveals β1 and β4 integrin mediate YAP translocation independently of cell spreading.

Lee JY, Dominguez AA, Nam S, Stowers RS, Qi LS, Chaudhuri O. Sci Rep. 2019 Nov 20;9(1):17188. doi: 10.1038/s41598-019-53659-4. PMID: 31748579; PMCID: PMC6868278. [PubMed]

Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy.

Haileselassie B, Joshi AU, Minhas PS, Mukherjee R, Andreasson KI, Mochly-Rosen D. J Neuroinflammation. 2020 Jan 27;17(1):36. doi: 10.1186/s12974-019-1689-8. PMID: 31987040; PMCID: PMC6986002. [PubMed]

Zscan4 binds nucleosomal microsatellite DNA and protects mouse two-cell embryos from DNA damage.

Srinivasan R, Nady N, Arora N, Hsieh LJ, Swigut T, Narlikar GJ, Wossidlo M, Wysocka J. Sci Adv. 2020 Mar 20;6(12):eaaz9115. doi: 10.1126/sciadv.aaz9115. PMID: 32219172; PMCID: PMC7083622. [PubMed]

Contribution of ‘clinically negligible’ residual kidney function to clearance of uremic solutes.

Toth-Manikowski SM, Sirich TL, Meyer TW, Hostetter TH, Hwang S, Plummer NS, Hai X, Coresh J, Powe NR, Shafi T. Nephrol Dial Transplant. 2020 May 1;35(5):846-853. doi: 10.1093/ndt/gfz042. PMID: 30879076; PMCID: PMC7203561. [PubMed]

Intravital imaging reveals cell cycle-dependent myogenic cell migration during muscle regeneration.

Konagaya Y, Takakura K, Sogabe M, Bisaria A, Liu C, Meyer T, Sehara-Fujisawa A, Matsuda M, Terai K. Cell Cycle. 2020 Nov;19(22):3167-3181. doi: 10.1080/15384101.2020.1838779. Epub 2020 Nov 1. PMID: 33131406; PMCID: PMC7714504. [PubMed]

Membrane-proximal F-actin restricts local membrane protrusions and directs cell migration.

Bisaria A, Hayer A, Garbett D, Cohen D, Meyer T. Science. 2020 Jun 12;368(6496):1205-1210. doi: 10.1126/science.aay7794. PMID: 32527825. [PubMed]

T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration.

Garbett D, Bisaria A, Yang C, McCarthy DG, Hayer A, Moerner WE, Svitkina TM, Meyer T. Nat Commun. 2020 Sep 23;11(1):4818. doi: 10.1038/s41467-020-18586-3. PMID: 32968060; PMCID: PMC7511357. [PubMed]

Altered G1 signaling order and commitment point in cells proliferating without CDK4/6 activity.

Liu C, Konagaya Y, Chung M, Daigh LH, Fan Y, Yang HW, Terai K, Matsuda M, Meyer T. Nat Commun. 2020 Oct 20;11(1):5305. doi: 10.1038/s41467-020-18966-9. PMID: 33082317; PMCID: PMC7576148. [PubMed]

A Qualitative Study on the Differences Between Trial Populations and the Approved Therapeutic Indications of Antineoplastic Agents by 3 Regulatory Agencies From 2010 to 2018.

Sumi E, Asada R, Lu Y, Ito-Ihara T, Grimes KV. Clin Ther. 2020 Feb;42(2):305-320.e0. doi: 10.1016/j.clinthera.2020.01.002. Epub 2020 Jan 31. PMID: 32008723. [PubMed]

Opposing Effects of Cohesin and Transcription on CTCF Organization Revealed by Super-resolution Imaging.

Gu B, Comerci CJ, McCarthy DG, Saurabh S, Moerner WE, Wysocka J. Mol Cell. 2020 Oct 21:S1097-2765(20)30684-5. doi: 10.1016/j.molcel.2020.10.001. Epub ahead of print. PMID: 33091336. [PubMed]

The Effect of Ethanol Consumption on Composition and Morphology of Femur Cortical Bone in Wild-Type and ALDH2*2-Homozygous Mice.

Malkovskiy AV, Van Wassenhove LD, Goltsev Y, Osei-Sarfo K, Chen CH, Efron B, Gudas LJ, Mochly-Rosen D, Rajadas J. Calcif Tissue Int. 2020 Oct 17. doi: 10.1007/s00223-020-00769-1. Epub ahead of print. PMID: 33068139. [PubMed]

Low-frequency ultrasound-mediated cytokine transfection enhances T cell recruitment at local and distant tumor sites

Ilovitsh T, Feng Y, Foiret J, Kheirolomoom A, Zhang H, Ingham ES, Ilovitsh A, Tumbale SK, Fite BZ, Wu B, Raie MN, Zhang N, Kare AJ, Chavez M, Qi LS, Pelled G, Gazit D, Vermesh O, Steinberg I, Gambhir SS, Ferrara KW. Proc Natl Acad Sci U S A. 2020 Jun 9;117(23):12674-12685. doi: 10.1073/pnas.1914906117. Epub 2020 May 19. PMID: 32430322 [PubMed]

p38 MAPK inhibition: A promising therapeutic approach for COVID-19

Grimes JM, Grimes KV. J Mol Cell Cardiol. 2020 Jul;144:63-65. doi: 10.1016/j.yjmcc.2020.05.007. Epub 2020 May 16. PMID: 32422320 Free PMC article. [PubMed]

FaceBase 3: analytical tools and FAIR resources for craniofacial and dental research

Samuels BD, Aho R, Brinkley JF, Bugacov A, Feingold E, Fisher S, Gonzalez-Reiche AS, Hacia JG, Hallgrimsson B, Hansen K, Harris MP, Ho TV, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Leslie EJ, Li H, Liao EC, Long H, Lu N, Maas RL, Marazita ML, Mohammed J, Prescott S, Schuler R, Selleri L, Spritz RA, Swigut T, van Bakel H, Visel A, Welsh I, Williams C, Williams TJ, Wysocka J, Yuan Y, Chai Y. Development. 2020 Sep 21;147(18):dev191213. doi: 10.1242/dev.191213. PMID: 32958507 [PubMed]

Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder

Long HK, Osterwalder M, Welsh IC, Hansen K, Davies JOJ, Liu YE, Koska M, Adams AT, Aho R, Arora N, Ikeda K, Williams RM, Sauka-Spengler T, Porteus MH, Mohun T, Dickel DE, Swigut T, Hughes JR, Higgs DR, Visel A, Selleri L, Wysocka J. Cell Stem Cell. 2020 Sep 22:S1934-5909(20)30447-1. doi: 10.1016/j.stem.2020.09.001. Online ahead of print. PMID: 32991838 [PubMed]

What Has a Century of Quantitative Genetics Taught Us About Nature’s Genetic Toolkit?

Jakobson CM, Jarosz DF. Annu Rev Genet. 2020 Sep 8. doi: 10.1146/annurev-genet-021920-102037. Online ahead of print. PMID: 32897739 [PubMed]