Publications

Roles of transposable elements in the regulation of mammalian transcription.

Fueyo R, Judd J, Feschotte C, Wysocka J. Nat Rev Mol Cell Biol. 2022 Feb 28. doi: 10.1038/s41580-022-00457-y. Online ahead of print. PMID: 35228718 Review. [PubMed]

Mitochondrial fusion, fission and mitophagy in cardiac diseases: challenges and therapeutic opportunities.

Scheffer DDL, Garcia AA, Lee L, Mochly-Rosen D, Ferreira JCB. Antioxid Redox Signal. 2022 Jan 19. doi: 10.1089/ars.2021.0145. Online ahead of print. PMID: 35044229 [PubMed]

Stabilization of glucose-6-phosphate dehydrogenase oligomers enhances catalytic activity and stability of clinical variants.

Garcia AA, Mathews II, Horikoshi N, Matsui T, Kaur M, Wakatsuki S, Mochly-Rosen D. J Biol Chem. 2022 Jan 19:101610. doi: 10.1016/j.jbc.2022.101610. Online ahead of print. [PubMed]

Drp1/Fis1-Dependent Pathologic Fission and Associated Damaged Extracellular Mitochondria Contribute to Macrophage Dysfunction in Endotoxin Tolerance.

Mukherjee R, Tompkins CA, Ostberg NP, Joshi AU, Massis LM, Vijayan V, Gera K, Monack D, Cornell TT, Hall MW, Mochly-Rosen D, Haileselassie B. Crit Care Med. 2022 Jan 24. doi: 10.1097/CCM.0000000000005437. Online ahead of print. PMID: 35067534 [PubMed]

Treatment-refractory ulcerative colitis responsive to indigo naturalis.

Saiki JP, Andreasson JO, Grimes KV, Frumkin LR, Sanjines E, Davidson MG, Park KT, Limketkai B. BMJ Open Gastroenterol. 2021 Dec;8(1):e000813. doi: 10.1136/bmjgast-2021-000813. PMID: 34969665 [PubMed]

Activation of PKCε-ALDH2 Axis Prevents 4-HNE-Induced Pain in Mice

Martins BB, Hösch NG, Alcantara QA, Budas GR, Chen CH, Mochly-Rosen D, Ferreira JCB, Zambelli VO. Biomolecules. 2021 Nov 30;11(12):1798. doi: 10.3390/biom11121798. PMID: 34944441 [PubMed]

Stepwise oxidations play key roles in the structural and functional regulations of DJ-1

Song IK, Kim MS, Ferrell JE Jr, Shin DH, Lee KJ. Biochem J. 2021 Oct 15;478(19):3505-3525. doi: 10.1042/BCJ20210245. PMID: 34515295 [PubMed]

Enhanced Cas12a multi-gene regulation using a CRISPR array separator.

Magnusson JP, Rios AR, Wu L, Qi LS. Elife. 2021 Sep 9;10:e66406. doi: 10.7554/eLife.66406. PMID: 34499031 [PubMed]

Contextual reprogramming of CAR-T cells for treatment of HER2+ cancers.

Yang Z, Li L, Turkoz A, Chen P, Harari-Steinfeld R, Bobbin M, Stefanson O, Choi H, Pietrobon V, Alphson B, Goswami A, Balan V, Kearney A, Patel D, Yang J, Inel D, Vinod V, Cesano A, Wang B, Roh KH, Qi LS, Marincola FM. J Transl Med. 2021 Nov 7;19(1):459. doi: 10.1186/s12967-021-03132-6. PMID: 34743703 [PubMed]

Small Molecule Control of Morpholino Antisense Oligonucleotide Function through Staudinger Reduction.

Darrah K, Wesalo J, Lukasak B, Tsang M, Chen JK, Deiters A. J Am Chem Soc. 2021 Oct 27. doi: 10.1021/jacs.1c08723. Online ahead of print. PMID: 34705461 [PubMed]

Protein aggregation and the evolution of stress resistance in clinical yeast.

Chen YR, Ziv I, Swaminathan K, Elias JE, Jarosz DF. Philos Trans R Soc Lond B Biol Sci. 2021 Jun 7;376(1826):20200127. doi: 10.1098/rstb.2020.0127. Epub 2021 Apr 19. PMID: 33866806 [PubMed]

A prion accelerates proliferation at the expense of lifespan.

Garcia DM, Campbell EA, Jakobson CM, Tsuchiya M, Shaw EA, DiNardo AL, Kaeberlein M, Jarosz DF. Elife. 2021 Sep 15;10:e60917. doi: 10.7554/eLife.60917. PMID: 34545808 [PubMed]

Metabolites control stress granule disassembly.

Jakobson CM, Jarosz DF. Nat Cell Biol. 2021 Oct;23(10):1053-1055. doi: 10.1038/s41556-021-00768-w. PMID: 34616025 [PubMed]

Massive QTL analysis identifies pleiotropic genetic determinants for stress resistance, aroma formation, and ethanol, glycerol and isobutanol production in Saccharomyces cerevisiae.

Ho PW, Piampongsant S, Gallone B, Del Cortona A, Peeters PJ, Reijbroek F, Verbaet J, Herrera B, Cortebeeck J, Nolmans R, Saels V, Steensels J, Jarosz DF, Verstrepen KJ. Biotechnol Biofuels. 2021 Nov 2;14(1):211. doi: 10.1186/s13068-021-02059-w. PMID: 34727964 [PubMed]

Annotation of 1350 Common Genetic Variants of the 19 ALDH Multigene Family from Global Human Genome Aggregation Database (gnomAD).

Chen CH, Kraemer BR, Lee L, Mochly-Rosen D. Biomolecules. 2021 Sep 29;11(10):1423. doi: 10.3390/biom11101423. PMID: 34680056 [PubMed]

Activation of Aldehyde Dehydrogenase 2 Ameliorates Glucolipotoxicity of Pancreatic Beta Cells.

Chen SM, Hee SW, Chou SY, Liu MW, Chen CH, Mochly-Rosen D, Chang TJ, Chuang LM. Biomolecules. 2021 Oct 6;11(10):1474. doi: 10.3390/biom11101474. PMID: 34680107 [PubMed]

δPKC-Mediated Drp1 Phosphorylation Impacts Macrophage Mitochondrial Function and Inflammatory Response to Endotoxin.

Lin AJ, Joshi AU, Mukherjee R, Tompkins CA, Vijayan V, Mochly-Rosen D, Haileselassie B. Shock. 2021 Nov 3. doi: 10.1097/SHK.0000000000001885. Online ahead of print. PMID: 34738957 [PubMed]

Genome scans of facial features in East Africans and cross-population comparisons reveal novel associations.

Liu C, Lee MK, Naqvi S, Hoskens H, Liu D, White JD, Indencleef K, Matthews H, Eller RJ, Li J, Mohammed J, Swigut T, Richmond S, Manyama M, Hallgrímsson B, Spritz RA, Feingold E, Marazita ML, Wysocka J, Walsh S, Shriver MD, Claes P, Weinberg SM, Shaffer JR. PLoS Genet. 2021 Aug 19;17(8):e1009695. doi: 10.1371/journal.pgen.1009695. eCollection 2021 Aug. PMID: 34411106 [PubMed]

Single-cell transcriptomic profiling reveals distinct mechanical responses between normal and diseased tendon progenitor cells.

Still C 2nd, Chang WT, Sherman SL, Sochacki KR, Dragoo JL, Qi LS. Cell Rep Med. 2021 Jul 21;2(7):100343. doi: 10.1016/j.xcrm.2021.100343. eCollection 2021 Jul 20. PMID: 34337559 [PubMed]

Interrogation of the dynamic properties of higher-order heterochromatin using CRISPR-dCas9.

Gao Y, Han M, Shang S, Wang H, Qi LS. Mol Cell. 2021 Aug 13:S1097-2765(21)00612-2. doi: 10.1016/j.molcel.2021.07.034. Online ahead of print. PMID: 34428454 [PubMed]

Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing.

Xu X, Chemparathy A, Zeng L, Kempton HR, Shang S, Nakamura M, Qi LS. Mol Cell. 2021 Aug 26:S1097-2765(21)00648-1. doi: 10.1016/j.molcel.2021.08.008. Online ahead of print. PMID: 34480847 [PubMed]

Treatment strategies for glucose-6-phosphate dehydrogenase deficiency: past and future perspectives.

Garcia AA, Koperniku A, Ferreira JCB, Mochly-Rosen D. Trends Pharmacol Sci. 2021 Aug 10:S0165-6147(21)00137-1. doi: 10.1016/j.tips.2021.07.002. Online ahead of print. PMID: 34389161 Review. [PubMed]

CRISPRi/a Screening with Human iPSCs.

Nishiga M, Qi LS, Wu JC. Methods Mol Biol. 2021;2320:261-281. doi: 10.1007/978-1-0716-1484-6_23. PMID: 34302664 [PubMed]

Catalytically inactive, purified RNase H1: A specific and sensitive probe for RNA-DNA hybrid imaging.

Crossley MP, Brickner JR, Song C, Zar SMT, Maw SS, Chédin F, Tsai MS, Cimprich KA. J Cell Biol. 2021 Sep 6;220(9):e202101092. doi: 10.1083/jcb.202101092. Epub 2021 Jul 7. PMID: 34232287 [PubMed]

Shared heritability of human face and brain shape.

Naqvi S, Sleyp Y, Hoskens H, Indencleef K, Spence JP, Bruffaerts R, Radwan A, Eller RJ, Richmond S, Shriver MD, Shaffer JR, Weinberg SM, Walsh S, Thompson J, Pritchard JK, Sunaert S, Peeters H, Wysocka J, Claes P. Nat Genet. 2021 Jun;53(6):830-839. doi: 10.1038/s41588-021-00827-w. Epub 2021 Apr 5. PMID: 33821002 [PubMed]