Publications

The Intersection of the Genetic Architectures of Orofacial Clefts and Normal Facial Variation.

Indencleef K, Hoskens H, Lee MK, White JD, Liu C, Eller RJ, Naqvi S, Wehby GL, Moreno Uribe LM, Hecht JT, Long RE Jr, Christensen K, Deleyiannis FW, Walsh S, Shriver MD, Richmond S, Wysocka J, Peeters H, Shaffer JR, Marazita ML, Hens G, Weinberg SM, Claes P. Front Genet. 2021 Feb 22;12:626403. doi: 10.3389/fgene.2021.626403. eCollection 2021. PMID: 33692830 Free PMC article. [PubMed]

Novel and prevalent non-East Asian ALDH2 variants; Implications for global susceptibility to aldehydes’ toxicity.

Chen CH, Ferreira JCB, Joshi AU, Stevens MC, Li SJ, Hsu JH, Maclean R, Ferreira ND, Cervantes PR, Martinez DD, Barrientos FL, Quintanares GHR, Mochly-Rosen D. EBioMedicine. 2020 May;55:102753. doi: 10.1016/j.ebiom.2020.102753. Epub 2020 May 8. PMID: 32403082 Free PMC article. [PubMed]

A Novel ALDH2 Activator AD-9308 Improves Diastolic and Systolic Myocardial Functions in Streptozotocin-Induced Diabetic Mice.

Lee HL, Hee SW, Hsuan CF, Yang W, Huang JY, Lin YL, Hsu CN, Hwang JJ, Chen SM, Ding ZZ, Lee TY, Lin YC, Tsai FC, Su WL, Chueh LY, Hsieh ML, Chen CH, Mochly-Rosen D, Chang YC, Chuang LM. Antioxidants (Basel). 2021 Mar 13;10(3):450. doi: 10.3390/antiox10030450. PMID: 33805825 [PubMed]

Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling.

Weber EW, Parker KR, Sotillo E, Lynn RC, Anbunathan H, Lattin J, Good Z, Belk JA, Daniel B, Klysz D, Malipatlolla M, Xu P, Bashti M, Heitzeneder S, Labanieh L, Vandris P, Majzner RG, Qi Y, Sandor K, Chen LC, Prabhu S, Gentles AJ, Wandless TJ, Satpathy AT, Chang HY, Mackall CL. Science. 2021 Apr 2;372(6537):eaba1786. doi: 10.1126/science.aba1786. PMID: 33795428 [PubMed]

Organic wastewater treatment by single-atom catalysis and electrolytically produced H2O2.

Xu, J., Zheng, X., Feng, Z., Lu, Z., Zhang, Z., Huang W., Li, Y., Vuckovic, D, Li, Y., Dai, S., Chen, G., Wang, K., WAng, H., Chen, J.K., Mitch, W., and Cui, Y. (2021) Nat. Sustain. 4: 233-241.

Engineering 3D genome organization.

Wang H, Han M, Qi LS. Nat Rev Genet. 2021 Feb 8. doi: 10.1038/s41576-020-00325-5. Epub ahead of print. PMID: 33558716. [PubMed]

The hunt for ancient prions: Archaeal prion-like domains form amyloid-based epigenetic elements.

Zajkowski T, Lee MD, Mondal SS, Carbajal A, Dec R, Brennock PD, Piast RW, Snyder JE, Bense NB, Dzwolak W, Jarosz DF, Rothschild LJ. Mol Biol Evol. 2021 Jan 22:msab010. doi: 10.1093/molbev/msab010. Online ahead of print. PMID: 33480998 [PubMed]

Protein self-assembly: A new frontier in cell signaling.

Saad S, Jarosz DF. Curr Opin Cell Biol. 2021 Jan 22;69:62-69. doi: 10.1016/j.ceb.2020.12.013. Online ahead of print. PMID: 33493989 Review. [PubMed]

CRISPR technologies for precise epigenome editing.

Nakamura M, Gao Y, Dominguez AA, Qi LS. Nat Cell Biol. 2021 Jan;23(1):11-22. doi: 10.1038/s41556-020-00620-7. Epub 2021 Jan 8. PMID: 33420494 Review. [PubMed]

Transposable elements as a potent source of diverse cis-regulatory sequences in mammalian genomes.

Sundaram V, Wysocka J. Philos Trans R Soc Lond B Biol Sci. 2020 Mar 30;375(1795):20190347. doi: 10.1098/rstb.2019.0347. Epub 2020 Feb 10. PMID: 32075564 Free PMC article. Review. [PubMed]

Epigenomic and Transcriptomic Changes During Human RPE EMT in a Stem Cell Model of Epiretinal Membrane Pathogenesis and Prevention by Nicotinamide.

Boles NC, Fernandes M, Swigut T, Srinivasan R, Schiff L, Rada-Iglesias A, Wang Q, Saini JS, Kiehl T, Stern JH, Wysocka J, Blenkinsop TA, Temple S. Stem Cell Reports. 2020 Apr 14;14(4):631-647. doi: 10.1016/j.stemcr.2020.03.009. Epub 2020 Apr 2. PMID: 32243845 Free PMC article. [PubMed]

Temporal dissection of an enhancer cluster reveals distinct temporal and functional contributions of individual elements.

Thomas HF, Kotova E, Jayaram S, Pilz A, Romeike M, Lackner A, Penz T, Bock C, Leeb M, Halbritter F, Wysocka J, Buecker C. Mol Cell. 2021 Jan 18:S1097-2765(20)30989-8. doi: 10.1016/j.molcel.2020.12.047. Online ahead of print. PMID: 33482114 [PubMed]

Reactivation of the pluripotency program precedes formation of the cranial neural crest.

Zalc A, Sinha R, Gulati GS, Wesche DJ, Daszczuk P, Swigut T, Weissman IL, Wysocka J. Science. 2021 Feb 5;371(6529):eabb4776. doi: 10.1126/science.abb4776. PMID: 33542111 [PubMed]

Long-range structural defects by pathogenic mutations in most severe glucose-6-phosphate dehydrogenase deficiency.

Horikoshi N, Hwang S, Gati C, Matsui T, Castillo-Orellana C, Raub AG, Garcia AA, Jabbarpour F, Batyuk A, Broweleit J, Xiang X, Chiang A, Broweleit R, Vöhringer-Martinez E, Mochly-Rosen D, Wakatsuki S. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):e2022790118. doi: 10.1073/pnas.2022790118. PMID: 33468660 [PubMed]

Restoring metabolism of myeloid cells reverses cognitive decline in ageing.

Minhas PS, Latif-Hernandez A, McReynolds MR, Durairaj AS, Wang Q, Rubin A, Joshi AU, He JQ, Gauba E, Liu L, Wang C, Linde M, Sugiura Y, Moon PK, Majeti R, Suematsu M, Mochly-Rosen D, Weissman IL, Longo FM, Rabinowitz JD, Andreasson KI. Nature. 2021 Feb;590(7844):122-128. doi: 10.1038/s41586-020-03160-0. Epub 2021 Jan 20. PMID: 33473210 [PubMed]

ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: a multi-omics analysis.

Hu YF, Wu CH, Lai TC, Chang YC, Hwang MJ, Chang TY, Weng CH, Chang PM, Chen CH, Mochly-Rosen D, Huang CF, Chen SA. Biochim Biophys Acta Mol Basis Dis. 2021 Jan 27:166088. doi: 10.1016/j.bbadis.2021.166088. Epub ahead of print. PMID: 33515676. [PubMed]

The nucleus serves as the pacemaker for the cell cycle.

Afanzar O, Buss GK, Stearns T, Ferrell JE Jr. Elife. 2020 Dec 7;9:e59989. doi: 10.7554/eLife.59989. PMID: 33284106 Free PMC article. [PubMed]

Bistable, Biphasic Regulation of PP2A-B55 Accounts for the Dynamics of Mitotic Substrate Phosphorylation.

Kamenz J, Gelens L, Ferrell JE Jr. Curr Biol. 2020 Dec 19:S0960-9822(20)31771-1. doi: 10.1016/j.cub.2020.11.058. Online ahead of print. PMID: 33357450 [PubMed]

Regenerating Urethral Striated Muscle by CRISPRi/dCas9-KRAB-Mediated Myostatin Silencing for Obesity-Associated Stress Urinary Incontinence.

Yuan H, Ruan Y, Tan Y, Reed-Maldonado AB, Chen Y, Zhao D, Wang Z, Zhou F, Peng D, Banie L, Wang G, Liu J, Lin G, Qi LS, Lue TF. CRISPR J. 2020 Dec;3(6):562-572. doi: 10.1089/crispr.2020.0077. PMID: 33346712 [PubMed]

Why Is the GFR So High? Implications for the Treatment of Kidney Failure.

Clin J Am Soc Nephrol. 2020 Dec 10:CJN.14300920. doi: 10.2215/CJN.14300920. Online ahead of print. PMID: 33303581 Review. [PubMed]

Insights into the genetic architecture of the human face.

White JD, Indencleef K, Naqvi S, Eller RJ, Hoskens H, Roosenboom J, Lee MK, Li J, Mohammed J, Richmond S, Quillen EE, Norton HL, Feingold E, Swigut T, Marazita ML, Peeters H, Hens G, Shaffer JR, Wysocka J, Walsh S, Weinberg SM, Shriver MD, Claes P. Nat Genet. 2020 Dec 7. doi: 10.1038/s41588-020-00741-7. Online ahead of print. PMID: 33288918 [PubMed]

Identification of cell context-dependent YAP-associated proteins reveals β1 and β4 integrin mediate YAP translocation independently of cell spreading.

Lee JY, Dominguez AA, Nam S, Stowers RS, Qi LS, Chaudhuri O. Sci Rep. 2019 Nov 20;9(1):17188. doi: 10.1038/s41598-019-53659-4. PMID: 31748579; PMCID: PMC6868278. [PubMed]

Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy.

Haileselassie B, Joshi AU, Minhas PS, Mukherjee R, Andreasson KI, Mochly-Rosen D. J Neuroinflammation. 2020 Jan 27;17(1):36. doi: 10.1186/s12974-019-1689-8. PMID: 31987040; PMCID: PMC6986002. [PubMed]

Zscan4 binds nucleosomal microsatellite DNA and protects mouse two-cell embryos from DNA damage.

Srinivasan R, Nady N, Arora N, Hsieh LJ, Swigut T, Narlikar GJ, Wossidlo M, Wysocka J. Sci Adv. 2020 Mar 20;6(12):eaaz9115. doi: 10.1126/sciadv.aaz9115. PMID: 32219172; PMCID: PMC7083622. [PubMed]

Contribution of ‘clinically negligible’ residual kidney function to clearance of uremic solutes.

Toth-Manikowski SM, Sirich TL, Meyer TW, Hostetter TH, Hwang S, Plummer NS, Hai X, Coresh J, Powe NR, Shafi T. Nephrol Dial Transplant. 2020 May 1;35(5):846-853. doi: 10.1093/ndt/gfz042. PMID: 30879076; PMCID: PMC7203561. [PubMed]