A genome-wide resource of phylogenetic profiles for human genes
Correlated patterns of homolog presence and absence across species can be used to infer functional links, in an approach termed phylogenetic profiling. The Meyer lab recently created a map of phylogenetic profiles and a pair-wise co-evolution matrix for every protein-coding gene in the human genome. This web resource can be used to explore the evolutionary history of any human gene of interest, examine its relationships to other members of the same gene family, view distribution of its orthologs across 177 eukaryotic species, and help discover new functional connections through lists of co-evolving human genes.
The web server is available here:
Read the accompanying paper, “Systematic Discovery of Human Gene Function and Principles of Modular Organization through Phylogenetic Profiling”, Cell Reports (2015) 10:1-14, here: