CSB

Stanford School of Medicine

Chemical & Systems Biology We explore how regulatory circuits control cells and organisms

 
 

PublicationsFeatured Publications

VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease.

Guo X, Sun X, Hu D, Wang YJ, Fujioka H, Vyas R, Chakrapani S, Joshi AU, Luo Y, Mochly-Rosen D, Qi X. (2016) Nat Commun.  2016 Aug 26;7:12646. doi: 10.1038/ncomms12646. [PubMed]

 

In vivo Post-Cardiac Arrest Myocardial Dysfunction is Supported by CaMKII-Mediated Calcium Long-Term Potentiation and Mitigated by Alda-1, an Agonist of Aldehyde Dehydrogenase Type 2.

Woods C, Shang C, Taghavi F, Downey P, Zalewski A, Rubio G, Liu J, Homburger J, Grunwald Z, Qi W, Bollensdorff C, Thanaporn P, Ali A, Riemer RK, Kohl P, Mochly Rosen D, Gerstenfeld E, Large S, Ali Z, Ashley E. (2016) Circulation 2016 Aug 31. pii: CIRCULATIONAHA.116.021618. [PubMed]

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PKC-ALDH2 Pathway Plays a Novel Role in Adipocyte Differentiation.

Yu YH, Liao PR, Guo CJ, Chen CH, Mochly-Rosen D, Chuang LM. (2016) PLoS One.  2016 Aug 30;11(8):e0161993. doi: 10.1371/journal.pone.0161993. [PubMed]

 

The genomic basis of adaptive evolution in threespine sticklebacks.

Jones FC1, Grabherr MG, Chan YF, Russell P, Mauceli E, Johnson J, Swofford R, Pirun M, Zody MC, White S, Birney E, Searle S, Schmutz J, Grimwood J, Dickson MC, Myers RM, Miller CT, Summers BR, Knecht AK, Brady SD, Zhang H, Pollen AA, Howes T, Amemiya C; Broad Institute Genome Sequencing Platform & Whole Genome Assembly Team, Baldwin J, Bloom T, Jaffe DB, Nicol R, Wilkinson J, Lander ES, Di Palma F, Lindblad-Toh K, Kingsley DM. (2012) Nature. 2012 Apr 4;484(7392):55-61. [PubMed]

A crucial requirement for Hedgehog signaling in small cell lung cancer.

Park KS, Martelotto LG, Peifer M, Sos ML, Karnezis AN, Mahjoub MR, Bernard K, Conklin JF, Szczepny A, Yuan J, Guo R, Ospina B, Falzon J, Bennett S, Brown TJ, Markovic A, Devereux WL, Ocasio CA, Chen JK, Stearns T, Thomas RK, Dorsch M, Buonamici S, Watkins DN, Peacock CD, Sage J. (2011) Nat. Med. 17(11):1504-8 [PubMed]

Systems biologists seek fuller integration of systems biology approaches in new cancer research programs.

Wolkenhauer O, Auffray C, Baltrusch S, Blüthgen N, Byrne H, Cascante M, Ciliberto A, Dale T, Drasdo D, Fell D, Ferrell JE, Gallahan D, Gatenby R, Günther U, Harms BD, Herzel H, Junghanss C, Kunz M, van Leeuwen I, Lenormand P, Levi F, Linnebacher M, Lowengrub J, Maini PK, Malik A, Rateitschak K, Sansom O, Schäfer R, Schürrle K, Sers C, Schnell S, Shibata D, Tyson J, Vera J, White M, Zhivotovsky B, Jaster R. (2010) Cancer Res. 70(1):12-3 [PubMed]

Overview of the Alliance for Cellular Signaling.

Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O’Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O’Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR. (2002) Nature 420(6916):703-6 [PubMed]

Expression-interaction cloning.

Csukai M, Mochly-Rosen D. In Methods in Molecular Biology: Protein Targeting Protocols. R.A. Clegg (ed). Humana Press, Inc., Totowa, NJ, pp 133-139, 1997.

G protein and alcoholism.

Gordon AS, Mochly-Rosen D, Diamond I. In Dysfunction of G-protein linked cascades in cellular pathology. Milligan G and Wakelam MJO (eds). Academic Press, 1991.