The Cdk1-APC/C cell cycle oscillator circuit functions as a time-delayed, ultrasensitive switch.
Yang Q, Ferrell JE Jr. (2013) Nat. Cell. Biol. 15(5):519-25 [PubMed]
Chemical & Systems Biology
Publications
A Role for the MRN Complex in ATR Activation via TOPBP1 Recruitment.
Duursma AM, Driscoll R, Elias JE, Cimprich KA. (2013) Mol. Cell. 50(1):116-22 [ScienceDirect]
A localized Wnt signal orients asymmetric stem cell division in vitro.
Habib SJ, Chen BC, Tsai FC, Anastassiadis K, Meyer T, Betzig E, Nusse R. (2013) Science. 339(6126):1445-8 [PubMed]
Modification of enhancer chromatin: what, how, and why?
Calo E, Wysocka J. (2013) Mol. Cell. 49(5):825-37 [PubMed]
Selective activation of protein kinase Cϵ in mitochondria is neuroprotective in vitro and reduces focal ischemic brain injury in mice.
Sun X, Budas GR, Xu L, Barreto GE, Mochly-Rosen D, Giffard RG. (2013) J. Neurosci. Res. [PubMed]
Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development.
Li W, Xiong Y, Shang C, Twu KY, Hang CT, Yang J, Han P, Lin CY, Lin CJ, Tsai FC, Stankunas K, Meyer T, Bernstein D, Pan M, Chang CP. (2013) Proc. Natl. Acad. Sci. 110(5):1738-43 [PubMed]
The chromatin remodeling factor Chd1l is required in the preimplantation embryo.
Snider AC, Leong D, Wang QT, Wysocka J, Yao MW, Scott MP. (2013) Biol. Open. 2(2):121-31 [PubMed]
Design of experiments to investigate dynamic cell signaling models.
Bandara S, Meyer T. (2012) Methods Mol. Biol. 880:109-18 [PubMed]
Bistability in one equation or fewer.
Anderson GA, Liu X, Ferrell JE Jr. (2012) Methods Mol Biol. 880:53-67 [PubMed]
In vivo measurement of aldehyde dehydrogenase-2 activity in rat liver ethanol model using dynamic MRSI of hyperpolarized [1-(13) C]pyruvate.
Josan S, Xu T, Yen YF, Hurd R, Ferreira J, Chen CH, Mochly-Rosen D, Pfefferbaum A, Mayer D, Spielman D. (2012) NMR Biomed. [PubMed]
Protein kinase C, an elusive therapeutic target?
Mochly-Rosen D, Das K, Grimes KV. (2012) Nat. Rev. Drug Discov. 11(12):937-57 [PubMed]
Coordinated oscillations in cortical actin and Ca2+ correlate with cycles of vesicle secretion.
Wollman R, Meyer T. (2012) Nat. Cell Biol. 14(12):1261-9 [PubMed]
Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest.
Rada-Iglesias A, Bajpai R, Prescott S, Brugmann SA, Swigut T, Wysocka J. (2012) Cell Stem Cell 11(5):633-48 [PubMed]
Consecutive positive feedback loops create a bistable switch that controls preadipocyte-to-adipocyte conversion.
Park BO, Ahrends R, Teruel MN. (2012) Cell Rep 2(4):976-90 [PubMed]
Intracellular context affects levels of a chemically dependent destabilizing domain.
Sellmyer MA, Chen LC, Egeler EL, Rakhit R, Wandless TJ. (2012) PLoS ONE 7(9):e43297 [PubMed]
External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane.
Galic M, Jeong S, Tsai FC, Joubert LM, Wu YI, Hahn KM, Cui Y, Meyer T. (2012) Nat. Cell Biol. 14(8):874-81 [PubMed]
Differential trafficking of transport vesicles contributes to the localization of dendritic proteins.
Al-Bassam S, Xu M, Wandless TJ, Arnold DB. (2012) Cell Rep. 2(1):89-100 [PubMed]
Cyclic caged morpholinos: conformationally gated probes of embryonic gene function.
Yamazoe S, Shestopalov IA, Provost E, Leach SD, Chen JK. (2012) Angew. Chem. Int. Ed. Engl. 51(28):6908-11 [PubMed]
Mitigation of radiation-induced dermatitis by activation of aldehyde dehydrogenase 2 using topical alda-1 in mice.
Ning S, Budas GR, Churchill EN, Chen CH, Knox SJ, Mochly-Rosen D. (2012) Radiat. Res. 178(1):69-74 [PubMed]
Spatial positive feedback at the onset of mitosis.
Santos SD, Wollman R, Meyer T, Ferrell JE. (2012) Cell 149(7):1500-13 [PubMed]
Bistability, bifurcations, and Waddington’s epigenetic landscape.
Ferrell JE. (2012) Curr. Biol. 22(11):R458-66 [PubMed]
Enhancers as information integration hubs in development: lessons from genomics.
Buecker C, Wysocka J. (2012) Trends Genet. 28(6):276-84 [PubMed]
Ca2+ pulses control local cycles of lamellipodia retraction and adhesion along the front of migrating cells.
Tsai FC, Meyer T. (2012) Curr. Biol. 22(9):837-42 [PubMed]
Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein.
Firestone AJ, Weinger JS, Maldonado M, Barlan K, Langston LD, O’Donnell M, Gelfand VI, Kapoor TM, Chen JK. (2012) Nature 484(7392):125-9 [PubMed]
The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome.
Kuo AJ, Song J, Cheung P, Ishibe-Murakami S, Yamazoe S, Chen JK, Patel DJ, Gozani O. (2012) Nature 484(7392):115-9 [PubMed]
Protein quality control disruption by PKCβII in heart failure; rescue by the selective PKCβII inhibitor, βIIV5-3.
Ferreira JC, Boer BN, Grinberg M, Brum PC, Mochly-Rosen D. (2012) PLoS ONE 7(3):e33175 [PubMed]
Identification of εPKC targets during cardiac ischemic injury.
Budas G, Costa HM, Ferreira JC, Teixeira da Silva Ferreira A, Perales J, Krieger JE, Mochly-Rosen D, Schechtman D. (2012) Circ. J. 76(6):1476-85 [PubMed]
Destabilizing domains derived from the human estrogen receptor.
Miyazaki Y, Imoto H, Chen LC, Wandless TJ. (2012) J. Am. Chem. Soc. 134(9):3942-5 [PubMed]
Spatiotemporal resolution of the Ntla transcriptome in axial mesoderm development.
Shestopalov IA, Pitt CL, Chen JK. (2012) Nat. Chem. Biol. 8(3):270-6 [PubMed]
A two-dimensional ERK-AKT signaling code for an NGF-triggered cell-fate decision.
Chen JY, Lin JR, Cimprich KA, Meyer T. (2012) Mol. Cell 45(2):196-209 [PubMed]
Imaging the impact of chemically inducible proteins on cellular dynamics in vivo.
Leong HS, Lizardo MM, Ablack A, McPherson VA, Wandless TJ, Chambers AF, Lewis JD. (2012) PLoS ONE 7(1):e30177 [PubMed]
Nitroglycerin use in myocardial infarction patients.
Ferreira JC, Mochly-Rosen D. (2012) Circ. J. 76(1):15-21 [PubMed]
Regulation of cardiac excitability by protein kinase C isozymes.
Ferreira JC, Mochly-Rosen D, Boutjdir M. (2012) Front Biosci (Schol Ed) 4:532-46 [PubMed]
A novel aldehyde dehydrogenase-3 activator leads to adult salivary stem cell enrichment in vivo.
Banh A, Xiao N, Cao H, Chen CH, Kuo P, Krakow T, Bavan B, Khong B, Yao M, Ha C, Kaplan MJ, Sirjani D, Jensen K, Kong CS, Mochly-Rosen D, Koong AC, Le QT. (2011) Clin. Cancer Res. 17(23):7265-72 [PubMed]
Pharmacological inhibition of βIIPKC is cardioprotective in late-stage hypertrophy.
Ferreira JC, Koyanagi T, Palaniyandi SS, Fajardo G, Churchill EN, Budas G, Disatnik MH, Bernstein D, Brum PC, Mochly-Rosen D. (2011) J. Mol. Cell. Cardiol. 51(6):980-7 [PubMed]
Hedgehog and retinoic acid signaling cooperate to promote motoneurogenesis in zebrafish.
Mich JK, Chen JK. (2011) Development 138(23):5113-9 [PubMed]
Neuropilins are positive regulators of Hedgehog signal transduction.
Hillman RT, Feng BY, Ni J, Woo WM, Milenkovic L, Hayden Gephart MG, Teruel MN, Oro AE, Chen JK, Scott MP. (2011) Genes Dev. 25(22):2333-46 [PubMed]
A mechanism for the evolution of phosphorylation sites.
Pearlman SM, Serber Z, Ferrell JE. (2011) Cell 147(4):934-46 [PubMed]
β2-adrenergic receptors mediate cardioprotection through crosstalk with mitochondrial cell death pathways.
Fajardo G, Zhao M, Berry G, Wong LJ, Mochly-Rosen D, Bernstein D. (2011) J. Mol. Cell. Cardiol. 51(5):781-9 [PubMed]
Salmonella exploits Arl8B-directed kinesin activity to promote endosome tubulation and cell-to-cell transfer.
Kaniuk NA, Canadien V, Bagshaw RD, Bakowski M, Braun V, Landekic M, Mitra S, Huang J, Heo WD, Meyer T, Pelletier L, Andrews-Polymenis H, McClelland M, Pawson T, Grinstein S, Brumell JH. (2011) Cell. Microbiol. 13(11):1812-23 [PubMed]
The phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii reveal unusual adaptations within and beyond the parasites’ boundaries.
Treeck M, Sanders JL, Elias JE, Boothroyd JC. (2011) Cell Host Microbe. 10(4):410-9 [PubMed]
A crucial requirement for Hedgehog signaling in small cell lung cancer.
Park KS, Martelotto LG, Peifer M, Sos ML, Karnezis AN, Mahjoub MR, Bernard K, Conklin JF, Szczepny A, Yuan J, Guo R, Ospina B, Falzon J, Bennett S, Brown TJ, Markovic A, Devereux WL, Ocasio CA, Chen JK, Stearns T, Thomas RK, Dorsch M, Buonamici S, Watkins DN, Peacock CD, Sage J. (2011) Nat. Med. 17(11):1504-8 [PubMed]
βIIPKC and εPKC isozymes as potential pharmacological targets in cardiac hypertrophy and heart failure.
Ferreira JC, Brum PC, Mochly-Rosen D. (2011) J. Mol. Cell. Cardiol. 51(4):479-84 [PubMed]
Spatiotemporal control of embryonic gene expression using caged morpholinos.
Shestopalov IA, Chen JK. (2011) Methods Cell Biol. 104:151-72 [PubMed]
Parallel adaptive feedback enhances reliability of the Ca2+ signaling system.
Abell E, Ahrends R, Bandara S, Park BO, Teruel MN. (2011) Proc. Natl. Acad. Sci. U.S.A. 108(35):14485-90 [PubMed]
Small-molecule displacement of a cryptic degron causes conditional protein degradation.
Bonger KM, Chen LC, Liu CW, Wandless TJ. (2011) Nat. Chem. Biol. 7(8):531-7 [PubMed]
PKCβII inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses.
Palaniyandi SS, Ferreira JC, Brum PC, Mochly-Rosen D. (2011) J. Cell. Mol. Med. 15(8):1769-77 [PubMed]
Chemical ‘Jekyll and Hyde’s: small-molecule inhibitors of developmental signaling pathways.
Sakata T, Chen JK. (2011) Chem Soc Rev 40(8):4318-31 [PubMed]
PKCδ activation mediates angiogenesis via NADPH oxidase activity in PC-3 prostate cancer cells.
Kim J, Koyanagi T, Mochly-Rosen D. (2011) Prostate 71(9):946-54 [PubMed]
STIM proteins and the endoplasmic reticulum-plasma membrane junctions.
Carrasco S, Meyer T. (2011) Annu. Rev. Biochem. 80:973-1000 [PubMed]
Therapeutic potential for protein kinase C inhibitor in vascular restenosis.
Ding RQ, Tsao J, Chai H, Mochly-Rosen D, Zhou W. (2011) J. Cardiovasc. Pharmacol. Ther. 16(2):160-7 [PubMed]
SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis.
Lin JR, Zeman MK, Chen JY, Yee MC, Cimprich KA. (2011) Mol. Cell 42(2):237-49 [PubMed]
The dynamic state of protein turnover: It’s about time.
Hinkson IV, Elias JE. (2011) Trends Cell Biol. 21(5):293-303 [PubMed]
Evolutionary origins of STIM1 and STIM2 within ancient Ca2+ signaling systems.
Collins SR, Meyer T. (2011) Trends Cell Biol. 21(4):202-11 [PubMed]
Matrix metalloproteinases modulated by protein kinase Cε mediate resistin-induced migration of human coronary artery smooth muscle cells.
Ding Q, Chai H, Mahmood N, Tsao J, Mochly-Rosen D, Zhou W. (2011) J. Vasc. Surg. 53(4):1044-51 [PubMed]
Chemical control of FGF-2 release for promoting calvarial healing with adipose stem cells.
Kwan MD, Sellmyer MA, Quarto N, Ho AM, Wandless TJ, Longaker MT. (2011) J. Biol. Chem. 286(13):11307-13 [PubMed]
Modeling the cell cycle: why do certain circuits oscillate?
Ferrell JE, Tsai TY, Yang Q. (2011) Cell 144(6):874-85 [PubMed]
A unique chromatin signature uncovers early developmental enhancers in humans.
Rada-Iglesias A, Bajpai R, Swigut T, Brugmann SA, Flynn RA, Wysocka J. (2011) Nature 470(7333):279-83 [PubMed]
Ultrasensitivity in the Regulation of Cdc25C by Cdk1.
Trunnell NB, Poon AC, Kim SY, Ferrell JE. (2011) Mol. Cell 41(3):263-74 [PubMed]
Sequence-specific regulator Prdm14 safeguards mouse ESCs from entering extraembryonic endoderm fates.
Ma Z, Swigut T, Valouev A, Rada-Iglesias A, Wysocka J. (2011) Nat. Struct. Mol. Biol. 18(2):120-7 [PubMed]
Sustained inhibition of PKCα reduces intravasation and lung seeding during mammary tumor metastasis in an in vivo mouse model.
Kim J, Thorne SH, Sun L, Huang B, Mochly-Rosen D. (2011) Oncogene 30(3):323-33 [PubMed]
Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivo.
Qi X, Disatnik MH, Shen N, Sobel RA, Mochly-Rosen D. (2011) Mol. Biol. Cell 22(2):256-65 [PubMed]
A tissue-specific atlas of mouse protein phosphorylation and expression.
Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villén J, Haas W, Sowa ME, Gygi SP. (2010) Cell 143(7):1174-89 [PubMed]
Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart Failure.
Qvit N, Mochly-Rosen D. (2010) Drug Discov Today Dis Mech 7(2):e87-e93 [PubMed]
Mitochondrial import of PKCε is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury.
Budas GR, Churchill EN, Disatnik MH, Sun L, Mochly-Rosen D. (2010) Cardiovasc. Res. 88(1):83-92 [PubMed]
Mitochondrial aldehyde dehydrogenase and cardiac diseases.
Chen CH, Sun L, Mochly-Rosen D. (2010) Cardiovasc. Res. 88(1):51-7 [PubMed]
A general chemical method to regulate protein stability in the mammalian central nervous system.
Iwamoto M, Björklund T, Lundberg C, Kirik D, Wandless TJ. (2010) Chem. Biol. 17(9):981-8 [PubMed]
The roles of cyclin A2, B1, and B2 in early and late mitotic events.
Gong D, Ferrell JE. (2010) Mol. Biol. Cell 21(18):3149-61 [PubMed]
Sustained inhibition of epsilon protein kinase C inhibits vascular restenosis after balloon injury and stenting.
Deuse T, Koyanagi T, Erben RG, Hua X, Velden J, Ikeno F, Reichenspurner H, Robbins RC, Mochly-Rosen D, Schrepfer S. (2010) Circulation 122(11 Suppl):S170-8 [PubMed]
Aldehyde dehydrogenase activation prevents reperfusion arrhythmias by inhibiting local renin release from cardiac mast cells.
Koda K, Salazar-Rodriguez M, Corti F, Chan NY, Estephan R, Silver RB, Mochly-Rosen D, Levi R. (2010) Circulation 122(8):771-81 [PubMed]
The NADPH oxidases NOX4 and DUOX2 regulate cell cycle entry via a p53-dependent pathway.
Salmeen A, Park BO, Meyer T. (2010) Oncogene 29(31):4473-84 [PubMed]
Synthetic strategies for studying embryonic development.
Ouyang X, Chen JK. (2010) Chem. Biol. 17(6):590-606 [PubMed]
Flipping MLL1′s switch one proline at a time.
Grow EJ, Wysocka J. (2010) Cell 141(7):1108-10 [PubMed]
Checkpoint recovery after DNA damage: a rolling stop for CDKs.
Duursma AM, Cimprich KA. (2010) EMBO Rep. 11(6):411-2 [PubMed]
Non-volume-loaded heart provides a more relevant heterotopic transplantation model.
Tang-Quan KR, Bartos J, Deuse T, Churchill E, Schäfer H, Reichenspurner H, Mochly-Rosen D, Robbins RC, Schrepfer S. (2010) Transpl. Immunol. 23(1-2):65-70 [PubMed]
Dicistronic regulation of fluorescent proteins in the budding yeast Saccharomyces cerevisiae.
Edwards SR, Wandless TJ. (2010) Yeast 27(4):229-36 [PubMed]
Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCε) knockout mice.
Budas GR, Disatnik MH, Chen CH, Mochly-Rosen D. (2010) J. Mol. Cell. Cardiol. 48(4):757-64 [PubMed]
δPKC inhibition or εPKC activation repairs endothelial vascular dysfunction by regulating eNOS post-translational modification.
Monti M, Donnini S, Giachetti A, Mochly-Rosen D, Ziche M. (2010) J. Mol. Cell. Cardiol. 48(4):746-56 [PubMed]
Oligonucleotide-based tools for studying zebrafish development.
Shestopalov IA, Chen JK. (2010) Zebrafish 7(1):31-40 [PubMed]
CHD7 cooperates with PBAF to control multipotent neural crest formation.
Bajpai R, Chen DA, Rada-Iglesias A, Zhang J, Xiong Y, Helms J, Chang CP, Zhao Y, Swigut T, Wysocka J. (2010) Nature 463(7283):958-62 [PubMed]
Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant.
Perez-Miller S, Younus H, Vanam R, Chen CH, Mochly-Rosen D, Hurley TD. (2010) Nat. Struct. Mol. Biol. 17(2):159-64 [PubMed]
Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen.
Bienvenu F, Jirawatnotai S, Elias JE, Meyer CA, Mizeracka K, Marson A, Frampton GM, Cole MF, Odom DT, Odajima J, Geng Y, Zagozdzon A, Jecrois M, Young RA, Liu XS, Cepko CL, Gygi SP, Sicinski P. (2010) Nature 463(7279):374-8 [PubMed]
Controlling destiny through chemistry: small-molecule regulators of cell fate.
Firestone AJ, Chen JK. (2010) ACS Chem. Biol. 5(1):15-34 [PubMed]
Ischaemic preconditioning improves proteasomal activity and increases the degradation of δPKC during reperfusion.
Churchill EN, Ferreira JC, Brum PC, Szweda LI, Mochly-Rosen D. (2010) Cardiovasc. Res. 85(2):385-94 [PubMed]
Regulation of mitochondrial processes: a target for heart failure.
Palaniyandi SS, Qi X, Yogalingam G, Ferreira JC, Mochly-Rosen D. (2010) Drug Discov Today Dis Mech 7(2):e95-e102 [PubMed]
MS/MS/MS reveals false positive identification of histone serine methylation.
Zhang J, Chen Y, Zhang Z, Xing G, Wysocka J, Zhao Y. (2010) J. Proteome Res. 9(1):585-94 [PubMed]
Systems biologists seek fuller integration of systems biology approaches in new cancer research programs.
Wolkenhauer O, Auffray C, Baltrusch S, Blüthgen N, Byrne H, Cascante M, Ciliberto A, Dale T, Drasdo D, Fell D, Ferrell JE, Gallahan D, Gatenby R, Günther U, Harms BD, Herzel H, Junghanss C, Kunz M, van Leeuwen I, Lenormand P, Levi F, Linnebacher M, Lowengrub J, Maini PK, Malik A, Rateitschak K, Sansom O, Schäfer R, Schürrle K, Sers C, Schnell S, Shibata D, Tyson J, Vera J, White M, Zhivotovsky B, Jaster R. (2010) Cancer Res. 70(1):12-3 [PubMed]
Target-decoy search strategy for mass spectrometry-based proteomics.
Elias JE, Gygi SP. (2010) Methods Mol. Biol. 604:55-71 [PubMed]
Identification of beta-secretase (BACE1) substrates using quantitative proteomics.
Hemming ML, Elias JE, Gygi SP, Selkoe DJ. (2009) PLoS ONE 4(12):e8477 [PubMed]
Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells.
Peng JC, Valouev A, Swigut T, Zhang J, Zhao Y, Sidow A, Wysocka J. (2009) Cell 139(7):1290-302 [PubMed]
Simple, realistic models of complex biological processes: positive feedback and bistability in a cell fate switch and a cell cycle oscillator.
Ferrell JE, Pomerening JR, Kim SY, Trunnell NB, Xiong W, Huang CY, Machleder EM. (2009) FEBS Lett. 583(24):3999-4005 [PubMed]
Signaling motifs and Weber’s law.
Ferrell JE. (2009) Mol. Cell 36(5):724-7 [PubMed]
Concordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNA.
Hendrickson DG, Hogan DJ, McCullough HL, Myers JW, Herschlag D, Ferrell JE, Brown PO. (2009) PLoS Biol. 7(11):e1000238 [PubMed]
Optimal experimental design for parameter estimation of a cell signaling model.
Bandara S, Schlöder JP, Eils R, Bock HG, Meyer T. (2009) PLoS Comput. Biol. 5(11):e1000558 [PubMed]
HARPing on about the DNA damage response during replication.
Driscoll R, Cimprich KA. (2009) Genes Dev. 23(20):2359-65 [PubMed]
Versatile synthesis and rational design of caged morpholinos.
Ouyang X, Shestopalov IA, Sinha S, Zheng G, Pitt CL, Li WH, Olson AJ, Chen JK. (2009) J. Am. Chem. Soc. 131(37):13255-69 [PubMed]
Regulated RalBP1 binding to RalA and PSD-95 controls AMPA receptor endocytosis and LTD.
Han K, Kim MH, Seeburg D, Seo J, Verpelli C, Han S, Chung HS, Ko J, Lee HW, Kim K, Heo WD, Meyer T, Kim H, Sala C, Choi SY, Sheng M, Kim E. (2009) PLoS Biol. 7(9):e1000187 [PubMed]
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.
Hyman JM, Firestone AJ, Heine VM, Zhao Y, Ocasio CA, Han K, Sun M, Rack PG, Sinha S, Wu JJ, Solow-Cordero DE, Jiang J, Rowitch DH, Chen JK. (2009) Proc. Natl. Acad. Sci. U.S.A. 106(33):14132-7 [PubMed]
A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability.
Paulsen RD, Soni DV, Wollman R, Hahn AT, Yee MC, Guan A, Hesley JA, Miller SC, Cromwell EF, Solow-Cordero DE, Meyer T, Cimprich KA. (2009) Mol. Cell 35(2):228-39 [PubMed]
Converse conformational control of smoothened activity by structurally related small molecules.
Yang H, Xiang J, Wang N, Zhao Y, Hyman J, Li S, Jiang J, Chen JK, Yang Z, Lin S. (2009) J. Biol. Chem. 284(31):20876-84 [PubMed]
Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target?
Budas GR, Disatnik MH, Mochly-Rosen D. (2009) Trends Cardiovasc. Med. 19(5):158-64 [PubMed]
Proliferating cell nuclear antigen uses two distinct modes to move along DNA.
Kochaniak AB, Habuchi S, Loparo JJ, Chang DJ, Cimprich KA, Walter JC, van Oijen AM. (2009) J. Biol. Chem. 284(26):17700-10 [PubMed]
Q&A: Cooperativity.
Ferrell JE. (2009) J. Biol. 8(6):53 [PubMed]
Protein kinase C in heart failure: a therapeutic target?
Palaniyandi SS, Sun L, Ferreira JC, Mochly-Rosen D. (2009) Cardiovasc. Res. 82(2):229-39 [PubMed]
Tuning the activation threshold of a kinase network by nested feedback loops.
Justman QA, Serber Z, Ferrell JE, El-Samad H, Shokat KM. (2009) Science 324(5926):509-12 [PubMed]
Fallen immortals.
Swigut T, Wysocka J. (2009) Cell 137(2):203-5 [PubMed]
Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent.
Mich JK, Blaser H, Thomas NA, Firestone AJ, Yelon D, Raz E, Chen JK. (2009) Dev. Biol. 328(2):342-54 [PubMed]
Preserved coronary endothelial function by inhibition of delta protein kinase C in a porcine acute myocardial infarction model.
Kaneda H, Ikeno F, Inagaki K, Mochly-Rosen D. (2009) Int. J. Cardiol. 133(2):256-9 [PubMed]
Quantitative analysis of cell cycle phase durations and PC12 differentiation using fluorescent biosensors.
Hahn AT, Jones JT, Meyer T. (2009) Cell Cycle 8(7):1044-52 [PubMed]
Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells.
Lim DA, Huang YC, Swigut T, Mirick AL, Garcia-Verdugo JM, Wysocka J, Ernst P, Alvarez-Buylla A. (2009) Nature 458(7237):529-33 [PubMed]
A small molecule that binds Hedgehog and blocks its signaling in human cells.
Stanton BZ, Peng LF, Maloof N, Nakai K, Wang X, Duffner JL, Taveras KM, Hyman JM, Lee SW, Koehler AN, Chen JK, Fox JL, Mandinova A, Schreiber SL. (2009) Nat. Chem. Biol. 5(3):154-6 [PubMed]
Regulating protein stability in mammalian cells using small molecules.
Hagan EL, Banaszynski LA, Chen LC, Maynard-Smith LA, Wandless TJ. (2009) Cold Spring Harb Protoc 2009(3):pdb.prot5172 [PubMed]
A general method for conditional regulation of protein stability in living animals.
Sellmyer MA, Thorne SH, Banaszynski LA, Contag CH, Wandless TJ. (2009) Cold Spring Harb Protoc 2009(3):pdb.prot5173 [PubMed]
The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling.
Cupido T, Rack PG, Firestone AJ, Hyman JM, Han K, Sinha S, Ocasio CA, Chen JK. (2009) Angew. Chem. Int. Ed. Engl. 48(13):2321-4 [PubMed]
Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of εPKC and activation of aldehyde dehydrogenase 2.
Churchill EN, Disatnik MH, Mochly-Rosen D. (2009) J. Mol. Cell. Cardiol. 46(2):278-84 [PubMed]
DNA damage tolerance: when it’s OK to make mistakes.
Chang DJ, Cimprich KA. (2009) Nat. Chem. Biol. 5(2):82-90 [PubMed]
Calcium flickers lighting the way in chemotaxis?
Collins SR, Meyer T. (2009) Dev. Cell 16(2):160-1 [PubMed]
Activating δPKC antagonizes the protective effect of ERK1/2 inhibition against stroke in rats.
Castañeda D, Zhao H, Mochly-Rosen D, Steinberg GK. (2009) Brain Res. 1251:256-61 [PubMed]
Q&A: systems biology.
Ferrell JE. (2009) J. Biol. 8(1):2 [PubMed]
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.
Rahdar M, Inoue T, Meyer T, Zhang J, Vazquez F, Devreotes PN. (2009) Proc. Natl. Acad. Sci. U.S.A. 106(2):480-5 [PubMed]
[Cytometric evaluation of immaturity granulocytes in infections].
Ratomski K, Zak J, Kasprzycka E, Hryniewicz K, Wysocka J. (2009) Pol. Merkur. Lekarski 26(151):14-8 [PubMed]
Rationally designed peptide regulators of protein kinase C.
Churchill EN, Qvit N, Mochly-Rosen D. (2009) Trends Endocrinol. Metab. 20(1):25-33 [PubMed]
The proteasome makes sense of mixed signals.
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SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes.
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Emi2 at the crossroads: where CSF meets MPF.
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The alliance for cellular signaling plasmid collection: a flexible resource for protein localization studies and signaling pathway analysis.
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Tuning bulk electrostatics to regulate protein function.
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Peptides derived from the C2 domain of protein kinase C epsilon (epsilon PKC) modulate epsilon PKC activity and identify potential protein-protein interaction surfaces.
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Analyzing the ATR-mediated checkpoint using Xenopus egg extracts.
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A network of Rab GTPases controls phagosome maturation and is modulated by Salmonella enterica serovar Typhimurium.
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Use of a novel method to find substrates of protein kinase C delta identifies M2 pyruvate kinase.
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Identifying novel proteins recognizing histone modifications using peptide pull-down assay.
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Minimizing off-target effects by using diced siRNAs for RNA interference.
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Mechanistic studies of the mitotic activation of Mos.
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Enhanced analysis of metastatic prostate cancer using stable isotopes and high mass accuracy instrumentation.
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A noisy ‘Start’ to the cell cycle.
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Investigating macromolecules inside cultured and injected cells by in-cell NMR spectroscopy.
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Interlinked fast and slow positive feedback loops drive reliable cell decisions.
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Characterization of mouse spleen cells by subtractive proteomics.
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PKC-ε-dependent survival signals in diabetic hearts.
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Spines and neurite branches function as geometric attractors that enhance protein kinase C action.
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Taking LSD 1 to a new high.
Wysocka J, Milne TA, Allis CD. (2005) Cell 122(5):654-8 [PubMed]
RSA 2004: combined basic research satellite symposium – session three: alcohol and mitochondrial metabolism: at the crossroads of life and death.
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Comparative evaluation of mass spectrometry platforms used in large-scale proteomics investigations.
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Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations.
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A cell-permeable, activity-based probe for protein and lipid kinases.
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Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis.
Marshall JG, Booth JW, Stambolic V, Mak T, Balla T, Schreiber AD, Meyer T, Grinstein S. (2001) J. Cell Biol. 153(7):1369-80 [PubMed]
Spontaneous occurrence of an inhibitor of protein kinase C localization in a thyroid cancer cell line: role in thyroid tumorigenesis.
Mochly-Rosen D, Fagin JA, Knauf JA, Nikiforov Y, Liron T, Schechtman D. (2001) Adv. Enzyme Regul. 41:87-97 [PubMed]
Loss of HCF-1-chromatin association precedes temperature-induced growth arrest of tsBN67 cells.
Wysocka J, Reilly PT, Herr W. (2001) Mol. Cell. Biol. 21(11):3820-9 [PubMed]
Developmental and cell-cycle regulation of Caenorhabditis elegans HCF phosphorylation.
Wysocka J, Liu Y, Kobayashi R, Herr W. (2001) Biochemistry 40(19):5786-94 [PubMed]
Calcineurin inhibitors and the generalization of the presenting protein strategy.
Vogel KW, Briesewitz R, Wandless TJ, Crabtree GR. (2001) Adv. Protein Chem. 56:253-91 [PubMed]
Arachidonic acid protects neonatal rat cardiac myocytes from ischaemic injury through epsilon protein kinase C.
Mackay K, Mochly-Rosen D. (2001) Cardiovasc. Res. 50(1):65-74 [PubMed]
Subcellular targeting by membrane lipids.
Hurley JH, Meyer T. (2001) Curr. Opin. Cell Biol. 13(2):146-52 [PubMed]
Opposing effects of delta and xi PKC in ethanol-induced cardioprotection.
Chen C, Mochly-Rosen D. (2001) J. Mol. Cell. Cardiol. 33(3):581-5 [PubMed]
Bistability in cell signaling: How to make continuous processes discontinuous, and reversible processes irreversible.
Ferrell JE, Xiong W. (2001) Chaos 11(1):227-236 [PubMed]
c-Jun N-terminal kinase activation in Xenopus laevis eggs and embryos. A possible non-genomic role for the JNK signaling pathway.
Bagowski CP, Xiong W, Ferrell JE. (2001) J. Biol. Chem. 276(2):1459-65 [PubMed]
Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis.
Botelho RJ, Teruel M, Dierckman R, Anderson R, Wells A, York JD, Meyer T, Grinstein S. (2000) J. Cell Biol. 151(7):1353-68 [PubMed]
Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint.
Hekmat-Nejad M, You Z, Yee MC, Newport JW, Cimprich KA. (2000) Curr. Biol. 10(24):1565-73 [PubMed]
Spatial sensing in fibroblasts mediated by 3′ phosphoinositides.
Haugh JM, Codazzi F, Teruel M, Meyer T. (2000) J. Cell Biol. 151(6):1269-80 [PubMed]
Synthesis of flavonol derivatives as probes of biological processes.
Tanaka H, Stohlmeyer MM, Wandless TJ, Taylor LP. (2000) Tetrahedron Letters 41:9735-9739. [PDF]
Evidence for functional role of εPKC isozyme in the regulation of cardiac Ca(2+) channels.
Hu K, Mochly-Rosen D, Boutjdir M. (2000) Am. J. Physiol. Heart Circ. Physiol. 279(6):H2658-64 [PubMed]
Disease attributed to Mycobacterium chelonae in South African clawed frogs (Xenopus laevis).
Green SL, Lifland BD, Bouley DM, Brown BA, Wallace RJ, Ferrell JE. (2000) Comp. Med. 50(6):675-9 [PubMed]
Mechanistic studies of affinity modulation.
Rosen MK, Amos CD, Wandless TJ. (2000) J. Am. Chem. Soc. 122:11979-11982 [PDF]
Studies of signal transduction events using chimeras to green fluorescent protein.
Meyer T, Oancea E. (2000) Meth. Enzymol. 327:500-13 [PubMed]
Cloning and characterization of Xenopus Rsk2, the predominant p90 Rsk isozyme in oocytes and eggs.
Bhatt RR, Ferrell JE. (2000) J. Biol. Chem. 275(42):32983-90 [PubMed]
Translocation and reversible localization of signaling proteins: a dynamic future for signal transduction.
Teruel MN, Meyer T. (2000) Cell 103(2):181-4 [PubMed]
What do scaffold proteins really do?
Ferrell JE. (2000) Sci. STKE 2000(52):pe1 [PubMed]
Protein kinase C isozymes and the regulation of diverse cell responses.
Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, Messing RO. (2000) Am. J. Physiol. Lung Cell Mol. Physiol. 279(3):L429-38 [PubMed]
Molecular memory by reversible translocation of calcium/calmodulin-dependent protein kinase II.
Shen K, Teruel MN, Connor JH, Shenolikar S, Meyer T. (2000) Nat. Neurosci. 3(9):881-6 [PubMed]
Inhibition of progesterone-induced Xenopus oocyte maturation by Nm23.
Kim SY, Ferrell JE, Chae SK, Lee KJ. (2000) Cell Growth Differ. 11(9):485-90 [PubMed]
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.
Taipale J, Chen JK, Cooper MK, Wang B, Mann RK, Milenkovic L, Scott MP, Beachy PA. (2000) Nature 406(6799):1005-9 [PubMed]
Involvement of a p38 mitogen-activated protein kinase phosphatase in protecting neonatal rat cardiac myocytes from ischemia.
Mackay K, Mochly-Rosen D. (2000) J. Mol. Cell. Cardiol. 32(8):1585-8 [PubMed]
A confederacy of bunches: fundamentals and applications of a self-associating protein.
Wandless TJ. (2000) Proc. Natl. Acad. Sci. U.S.A. 97(13):6921-3 [PubMed]
Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C.
Aley KO, Messing RO, Mochly-Rosen D, Levine JD. (2000) J. Neurosci. 20(12):4680-5 [PubMed]
Cardiotrophic effects of protein kinase C epsilon: analysis by in vivo modulation of PKCε translocation.
Mochly-Rosen D, Wu G, Hahn H, Osinska H, Liron T, Lorenz JN, Yatani A, Robbins J, Dorn GW. (2000) Circ. Res. 86(11):1173-9 [PubMed]
In and out of the postsynaptic region: signalling proteins on the move.
Meyer T, Shen K. (2000) Trends Cell Biol. 10(6):238-44 [PubMed]
Activation of Wee1 by p42 MAPK in vitro and in cycling xenopus egg extracts.
Walter SA, Guadagno SN, Ferrell JE. (2000) Mol. Biol. Cell 11(3):887-96 [PubMed]
Synthesis and evaluation of daunorubicin-paclitaxel dimers.
Kar AK, Braun PD, Wandless TJ. (2000) Bioorg. Med. Chem. Lett. 10(3):261-4 [PubMed]
Pharmacological regulation of network kinetics by protein kinase C localization.
Mochly-Rosen D, Kauvar LM. (2000) Semin. Immunol. 12(1):55-61 [PubMed]
Differential codes for free Ca(2+)-calmodulin signals in nucleus and cytosol.
Teruel MN, Chen W, Persechini A, Meyer T. (2000) Curr. Biol. 10(2):86-94 [PubMed]
Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion.
Raucher D, Stauffer T, Chen W, Shen K, Guo S, York JD, Sheetz MP, Meyer T. (2000) Cell 100(2):221-8 [PubMed]
The protein kinase p90 rsk as an essential mediator of cytostatic factor activity.
Bhatt RR, Ferrell JE. (1999) Science 286(5443):1362-5 [PubMed]
Distinct, constitutively active MAPK phosphatases function in Xenopus oocytes: implications for p42 MAPK regulation In vivo.
Sohaskey ML, Ferrell JE. (1999) Mol. Biol. Cell 10(11):3729-43 [PubMed]
A versatile microporation technique for the transfection of cultured CNS neurons.
Teruel MN, Blanpied TA, Shen K, Augustine GJ, Meyer T. (1999) J. Neurosci. Methods 93(1):37-48 [PubMed]
Cardioprotection from ischemia by a brief exposure to physiological levels of ethanol: role of epsilon protein kinase C.
Chen CH, Gray MO, Mochly-Rosen D. (1999) Proc. Natl. Acad. Sci. U.S.A. 96(22):12784-9 [PubMed]
Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation.
Dorn GW, Souroujon MC, Liron T, Chen CH, Gray MO, Zhou HZ, Csukai M, Wu G, Lorenz JN, Mochly-Rosen D. (1999) Proc. Natl. Acad. Sci. U.S.A. 96(22):12798-803 [PubMed]
RACK1, a protein kinase C anchoring protein, coordinates the binding of activated protein kinase C and select pleckstrin homology domains in vitro.
Rodriguez MM, Ron D, Touhara K, Chen CH, Mochly-Rosen D. (1999) Biochemistry 38(42):13787-94 [PubMed]
Xenopus oocyte maturation: new lessons from a good egg.
Ferrell JE. (1999) Bioessays 21(10):833-42 [PubMed]
Building a cellular switch: more lessons from a good egg.
Ferrell JE. (1999) Bioessays 21(10):866-70 [PubMed]
Protein kinase C-ε is responsible for the protection of preconditioning in rabbit cardiomyocytes.
Liu GS, Cohen MV, Mochly-Rosen D, Downey JM. (1999) J. Mol. Cell. Cardiol. 31(10):1937-48 [PubMed]
An efficient synthesis of β,γ-dehydrovaline.
Woiwode TF, Wandless TJ. (1999) J. Org. Chem. 64:7670-7674 [PDF]
Involvement of protein kinase Cε (PKCε) in thyroid cell death. A truncated chimeric PKCε cloned from a thyroid cancer cell line protects thyroid cells from apoptosis.
Knauf JA, Elisei R, Mochly-Rosen D, Liron T, Chen XN, Gonsky R, Korenberg JR, Fagin JA. (1999) J. Biol. Chem. 274(33):23414-25 [PubMed]
Characterization of the binding and phosphorylation of cardiac calsequestrin by epsilon protein kinase C.
Rodriguez MM, Chen CH, Smith BL, Mochly-Rosen D. (1999) FEBS Lett. 454(3):240-6 [PubMed]
Identification and management of an outbreak of Flavobacterium meningosepticum infection in a colony of South African clawed frogs (Xenopus laevis).
Green SL, Bouley DM, Tolwani RJ, Waggie KS, Lifland BD, Otto GM, Ferrell JE. (1999) J. Am. Vet. Med. Assoc. 214(12):1833-8, 1792-3 [PubMed]
A stereospecific elimination to form dehydroamino acids: synthesis of the phomopsin tripeptide sidechain.
Stohlmeyer MM, Tanaka H, Wandless TJ. (1999) J. Am. Chem. Soc. 121:6100-6101 [PDF]
M phase phosphorylation of cytoplasmic dynein intermediate chain and p150(Glued).
Huang CY, Chang CP, Huang CL, Ferrell JE. (1999) J. Biol. Chem. 274(20):14262-9 [PubMed]
Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium.
Improta-Brears T, Whorton AR, Codazzi F, York JD, Meyer T, McDonnell DP. (1999) Proc. Natl. Acad. Sci. U.S.A. 96(8):4686-91 [PubMed]
Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation.
Shen K, Meyer T. (1999) Science 284(5411):162-6 [PubMed]
Pharmacologic modulation of protein kinase C isozymes: the role of RACKs and subcellular localisation.
Csukai M, Mochly-Rosen D. (1999) Pharmacol. Res. 39(4):253-9 [PubMed]
An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia.
Mackay K, Mochly-Rosen D. (1999) J. Biol. Chem. 274(10):6272-9 [PubMed]
Affinity modulation of small-molecule ligands by borrowing endogenous protein surfaces.
Briesewitz R, Ray GT, Wandless TJ, Crabtree GR. (1999) Proc. Natl. Acad. Sci. U.S.A. 96(5):1953-8 [PubMed]
Characterization of a dextran-based bifunctional calcium indicator immobilized in cells by the enzymatic addition of isoprenoid lipids.
Horne JH, Meyer T. (1999) Cell Calcium 25(1):1-7 [PubMed]
How regulated protein translocation can produce switch-like responses.
Ferrell JE. (1998) Trends Biochem. Sci. 23(12):461-5 [PubMed]
A Simple and Efficient Method for the Preparation of Hindered Alkyl-Aryl Ethers.
Woiwode TF, Rose C, Wandless TJ. (1998) J. Org. Chem. 63:9594-9596 [PDF]
Requirement for MAPK activation for normal mitotic progression in Xenopus egg extracts.
Guadagno TM, Ferrell JE. (1998) Science 282(5392):1312-5 [PubMed]
Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis.
Laudanna C, Mochly-Rosen D, Liron T, Constantin G, Butcher EC. (1998) J. Biol. Chem. 273(46):30306-15 [PubMed]
Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals.
Oancea E, Meyer T. (1998) Cell 95(3):307-18 [PubMed]
Peptide modulators of protein-protein interactions in intracellular signaling.
Souroujon MC, Mochly-Rosen D. (1998) Nat. Biotechnol. 16(10):919-24 [PubMed]
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.
Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD. (1998) Science 281(5383):1677-9 [PubMed]
CaMKIIbeta functions as an F-actin targeting module that localizes CaMKIIalpha/beta heterooligomers to dendritic spines.
Shen K, Teruel MN, Subramanian K, Meyer T. (1998) Neuron 21(3):593-606 [PubMed]
Molecular genetic approaches. II. Expression-interaction cloning.
Csukai M, Mochly-Rosen D. (1998) Methods Mol. Biol. 88:133-9 [PubMed]
Activation of epsilon protein kinase C correlates with a cardioprotective effect of regular ethanol consumption.
Miyamae M, Rodriguez MM, Camacho SA, Diamond I, Mochly-Rosen D, Figueredo VM. (1998) Proc. Natl. Acad. Sci. U.S.A. 95(14):8262-7 [PubMed]
Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt.
Kontos CD, Stauffer TP, Yang WP, York JD, Huang L, Blanar MA, Meyer T, Peters KG. (1998) Mol. Cell. Biol. 18(7):4131-40 [PubMed]
The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes.
Ferrell JE, Machleder EM. (1998) Science 280(5365):895-8 [PubMed]
Visualization of dynamic trafficking of a protein kinase C betaII/green fluorescent protein conjugate reveals differences in G protein-coupled receptor activation and desensitization.
Feng X, Zhang J, Barak LS, Meyer T, Caron MG, Hannun YA. (1998) J. Biol. Chem. 273(17):10755-62 [PubMed]
Modulating protein kinase C signal transduction.
Mochly-Rosen D, Kauvar LM. (1998) Adv. Pharmacol. 44:91-145 [PubMed]
Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells.
Stauffer TP, Ahn S, Meyer T. (1998) Curr. Biol. 8(6):343-6 [PubMed]
Green fluorescent protein (GFP)-tagged cysteine-rich domains from protein kinase C as fluorescent indicators for diacylglycerol signaling in living cells.
Oancea E, Teruel MN, Quest AF, Meyer T. (1998) J. Cell Biol. 140(3):485-98 [PubMed]
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints.
Cliby WA, Roberts CJ, Cimprich KA, Stringer CM, Lamb JR, Schreiber SL, Friend SH. (1998) EMBO J. 17(1):159-69 [PubMed]
Anchoring proteins for protein kinase C: a means for isozyme selectivity.
Mochly-Rosen D, Gordon AS. (1998) FASEB J. 12(1):35-42 [PubMed]
In vivo and in vitro characterization of the sequence requirement for oligomer formation of Ca2+/calmodulin-dependent protein kinase IIalpha.
Shen K, Meyer T. (1998) J. Neurochem. 70(1):96-104 [PubMed]
Compartmentalized IgE receptor-mediated signal transduction in living cells.
Stauffer TP, Meyer T. (1997) J. Cell Biol. 139(6):1447-54 [PubMed]
A selective epsilon-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death.
Gray MO, Karliner JS, Mochly-Rosen D. (1997) J. Biol. Chem. 272(49):30945-51 [PubMed]
Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular trafficking.
Thissen JA, Gross JM, Subramanian K, Meyer T, Casey PJ. (1997) J. Biol. Chem. 272(48):30362-70 [PubMed]
The coatomer protein beta’-COP, a selective binding protein (RACK) for protein kinase Cε.
Csukai M, Chen CH, De Matteis MA, Mochly-Rosen D. (1997) J. Biol. Chem. 272(46):29200-6 [PubMed]
Induction of a G2-phase arrest in Xenopus egg extracts by activation of p42 mitogen-activated protein kinase.
Walter SA, Guadagno TM, Ferrell JE. (1997) Mol. Biol. Cell 8(11):2157-69 [PubMed]
Electroporation-induced formation of individual calcium entry sites in the cell body and processes of adherent cells.
Teruel MN, Meyer T. (1997) Biophys. J. 73(4):1785-96 [PubMed]
Inhibition of Lyn function in mast cell activation by SH3 domain binding peptides.
Stauffer TP, Martenson CH, Rider JE, Kay BK, Meyer T. (1997) Biochemistry 36(31):9388-94 [PubMed]
How responses get more switch-like as you move down a protein kinase cascade.
Ferrell JE. (1997) Trends Biochem. Sci. 22(8):288-9 [PubMed]
Mechanistic studies of the dual phosphorylation of mitogen-activated protein kinase.
Ferrell JE, Bhatt RR. (1997) J. Biol. Chem. 272(30):19008-16 [PubMed]
Calcium-induced restructuring of nuclear envelope and endoplasmic reticulum calcium stores.
Subramanian K, Meyer T. (1997) Cell 89(6):963-71 [PubMed]
Elementary calcium-release units induced by inositol trisphosphate.
Horne JH, Meyer T. (1997) Science 276(5319):1690-3 [PubMed]
An inhibitory fragment derived from protein kinase Cε prevents enhancement of nerve growth factor responses by ethanol and phorbol esters.
Hundle B, McMahon T, Dadgar J, Chen CH, Mochly-Rosen D, Messing RO. (1997) J. Biol. Chem. 272(23):15028-35 [PubMed]
Control of action potential-induced Ca2+ signaling in the soma of hippocampal neurons by Ca2+ release from intracellular stores.
Jacobs JM, Meyer T. (1997) J. Neurosci. 17(11):4129-35 [PubMed]
C2 region-derived peptides of beta-protein kinase C regulate cardiac Ca2+ channels.
Zhang ZH, Johnson JA, Chen L, El-Sherif N, Mochly-Rosen D, Boutjdir M. (1997) Circ. Res. 80(5):720-9 [PubMed]
A role for mitogen-activated protein kinase in the spindle assembly checkpoint in XTC cells.
Wang XM, Zhai Y, Ferrell JE. (1997) J. Cell Biol. 137(2):433-43 [PubMed]
Internal trafficking and surface mobility of a functionally intact beta2-adrenergic receptor-green fluorescent protein conjugate.
Barak LS, Ferguson SS, Zhang J, Martenson C, Meyer T, Caron MG. (1997) Mol. Pharmacol. 51(2):177-84 [PubMed]
Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic beta-cells.
Yedovitzky M, Mochly-Rosen D, Johnson JA, Gray MO, Ron D, Abramovitch E, Cerasi E, Nesher R. (1997) J. Biol. Chem. 272(3):1417-20 [PubMed]
Expression-interaction cloning.
Csukai M, Mochly-Rosen D. In Methods in Molecular Biology: Protein Targeting Protocols. R.A. Clegg (ed). Humana Press, Inc., Totowa, NJ, pp 133-139, 1997.
An improved permeabilization protocol for the introduction of peptides into cardiac myocytes. Application to protein kinase C research.
Johnson JA, Gray MO, Karliner JS, Chen CH, Mochly-Rosen D. (1996) Circ. Res. 79(6):1086-99 [PubMed]
Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs.
Ferrell JE. (1996) Trends Biochem. Sci. 21(12):460-6 [PubMed]
Ethanol and signal transduction in the myocardium: implications for the detrimental and beneficial effects.
Figueredo VM, Mochly-Rosen D. In Alcohol and the Cardiovascular System. Zakhari S and Wassef M (eds). CSR, Inc., Washington, DC pp 263-277, 1996.
A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function.
Johnson JA, Gray MO, Chen CH, Mochly-Rosen D. (1996) J. Biol. Chem. 271(40):24962-6 [PubMed]
Spatial dynamics of GFP-tagged proteins investigated by local fluorescence enhancement.
Yokoe H, Meyer T. (1996) Nat. Biotechnol. 14(10):1252-6 [PubMed]
Ultrasensitivity in the mitogen-activated protein kinase cascade.
Huang CY, Ferrell JE. (1996) Proc. Natl. Acad. Sci. U.S.A. 93(19):10078-83 [PubMed]
Differential activation of protein kinase C isozymes by phorbol ester and collagen in human skin microvascular endothelial cells.
Zhou LY, Disatnik M, Herron GS, Mochly-Rosen D, Karasek MA. (1996) J. Invest. Dermatol. 107(2):248-52 [PubMed]
Reversible desensitization of inositol trisphosphate-induced calcium release provides a mechanism for repetitive calcium spikes.
Oancea E, Meyer T. (1996) J. Biol. Chem. 271(29):17253-60 [PubMed]
The HIV nef protein associates with protein kinase C theta.
Smith BL, Krushelnycky BW, Mochly-Rosen D, Berg P. (1996) J. Biol. Chem. 271(28):16753-7 [PubMed]
Signal transduction by the polymeric immunoglobulin receptor suggests a role in regulation of receptor transcytosis.
Cardone MH, Smith BL, Mennitt PA, Mochly-Rosen D, Silver RB, Mostov KE. (1996) J. Cell Biol. 133(5):997-1005 [PubMed]
Dependence of Mos-induced Cdc2 activation on MAP kinase function in a cell-free system.
Huang CY, Ferrell JE. (1996) EMBO J. 15(9):2169-73 [PubMed]
cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein.
Cimprich KA, Shin TB, Keith CT, Schreiber SL. (1996) Proc. Natl. Acad. Sci. U.S.A. 93(7):2850-5 [PubMed]
SH2 domains: a question of independence.
Wandless TJ. (1996) Curr. Biol. 6(2):125-7 [PubMed]
MAP kinases in mitogenesis and development.
Ferrell JE. (1996) Curr. Top. Dev. Biol. 33:1-60 [PubMed]
Stimulus-dependent subcellular localization of activated protein kinase C; a study with acidic fibroblast growth factor and transforming growth factor-beta 1 in cardiac myocytes.
Disatnik MH, Jones SN, Mochly-Rosen D. (1995) J. Mol. Cell. Cardiol. 27(11):2473-81 [PubMed]
C2 region-derived peptides inhibit translocation and function of beta protein kinase C in vivo.
Ron D, Luo J, Mochly-Rosen D. (1995) J. Biol. Chem. 270(41):24180-7 [PubMed]
Luminal calcium regulates the inositol trisphosphate receptor of rat basophilic leukemia cells at a cytosolic site.
Horne JH, Meyer T. (1995) Biochemistry 34(39):12738-46 [PubMed]
The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor.
Brzoska PM, Chen H, Zhu Y, Levin NA, Disatnik MH, Mochly-Rosen D, Murnane JP, Christman MF. (1995) Proc. Natl. Acad. Sci. U.S.A. 92(17):7824-8 [PubMed]
Interaction of protein kinase C with RACK1, a receptor for activated C-kinase: a role in beta protein kinase C mediated signal transduction.
Mochly-Rosen D, Smith BL, Chen CH, Disatnik MH, Ron D. (1995) Biochem. Soc. Trans. 23(3):596-600 [PubMed]
Localized calcium signals in early zebrafish development.
Reinhard E, Yokoe H, Niebling KR, Allbritton NL, Kuhn MA, Meyer T. (1995) Dev. Biol. 170(1):50-61 [PubMed]
Localization of protein kinases by anchoring proteins: a theme in signal transduction.
Mochly-Rosen D. (1995) Science 268(5208):247-51 [PubMed]
Inhibition of the spontaneous rate of contraction of neonatal cardiac myocytes by protein kinase C isozymes. A putative role for the epsilon isozyme.
Johnson JA, Mochly-Rosen D. (1995) Circ. Res. 76(4):654-63 [PubMed]
Potent stimulation of SH-PTP2 phosphatase activity by simultaneous occupancy of both SH2 domains.
Pluskey S, Wandless TJ, Walsh CT, Shoelson SE. (1995) J. Biol. Chem. 270(7):2897-900 [PubMed]
An autoregulatory region in protein kinase C: the pseudoanchoring site.
Ron D, Mochly-Rosen D. (1995) Proc. Natl. Acad. Sci. U.S.A. 92(2):492-6 [PubMed]
Prolonged phorbol ester treatment down-regulates protein kinase C isozymes and increases contraction rate in neonatal cardiac myocytes.
Johnson JA, Adak S, Mochly-Rosen D. (1995) Life Sci. 57(11):1027-38 [PubMed]
Regulation of nuclear calcium concentration.
Meyer T, Allbritton NL, Oancea E. (1995) Ciba Found. Symp. 188:252-62; discussion 262-6 [PubMed]
Source of nuclear calcium signals.
Allbritton NL, Oancea E, Kuhn MA, Meyer T. (1994) Proc. Natl. Acad. Sci. U.S.A. 91(26):12458-62 [PubMed]
Agonists and antagonists of protein kinase C function, derived from its binding proteins.
Ron D, Mochly-Rosen D. (1994) J. Biol. Chem. 269(34):21395-8 [PubMed]
Distinct responses of protein kinase C isozymes to c-erbB-2 activation in SKBR-3 human breast carcinoma cells.
Disatnik MH, Winnier AR, Mochly-Rosen D, Arteaga CL. (1994) Cell Growth Differ. 5(8):873-80 [PubMed]
Developmental expression of protein kinase C subspecies in rat brain-pituitary axis.
Garcia-Navarro S, Marantz Y, Eyal R, Kalina M, Disatnik MH, Mochly-Rosen D, Ben-Menahem D, Reiss N, Naor Z. (1994) Mol. Cell. Endocrinol. 103(1-2):133-8 [PubMed]
Evidence that inactive p42 mitogen-activated protein kinase and inactive Rsk exist as a heterodimer in vivo.
Hsiao KM, Chou SY, Shih SJ, Ferrell JE. (1994) Proc. Natl. Acad. Sci. U.S.A. 91(12):5480-4 [PubMed]
Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1.
Sugimoto S, Wandless TJ, Shoelson SE, Neel BG, Walsh CT. (1994) J. Biol. Chem. 269(18):13614-22 [PubMed]
Dual role of calmodulin in autophosphorylation of multifunctional CaM kinase may underlie decoding of calcium signals.
Hanson PI, Meyer T, Stryer L, Schulman H. (1994) Neuron 12(5):943-56 [PubMed]
Phorbol myristate acetate-mediated stimulation of transcytosis and apical recycling in MDCK cells.
Cardone MH, Smith BL, Song W, Mochly-Rosen D, Mostov KE. (1994) J. Cell Biol. 124(5):717-27 [PubMed]
Localization of protein kinase C isozymes in cardiac myocytes.
Disatnik MH, Buraggi G, Mochly-Rosen D. (1994) Exp. Cell Res. 210(2):287-97 [PubMed]
Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins.
Ron D, Chen CH, Caldwell J, Jamieson L, Orr E, Mochly-Rosen D. (1994) Proc. Natl. Acad. Sci. U.S.A. 91(3):839-43 [PubMed]
Phospholipase C-gamma 1 binding to intracellular receptors for activated protein kinase C.
Disatnik MH, Hernandez-Sotomayor SM, Jones G, Carpenter G, Mochly-Rosen D. (1994) Proc. Natl. Acad. Sci. U.S.A. 91(2):559-63 [PubMed]
Controlling signal transduction with synthetic ligands.
Spencer DM, Wandless TJ, Schreiber SL, Crabtree GR. (1993) Science 262(5136):1019-24 [PubMed]
Localized calcium spikes and propagating calcium waves.
Allbritton NL, Meyer T. (1993) Cell Calcium 14(10):691-7 [PubMed]
Use of intracellular Ca2+ stores from rat basophilic leukemia cells to study the molecular mechanism leading to quantal Ca2+ release by inositol 1,4,5-trisphosphate.
Kindman LA, Meyer T. (1993) Biochemistry 32(5):1270-7 [PubMed]
Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate.
Allbritton NL, Meyer T, Stryer L. (1992) Science 258(5089):1812-5 [PubMed]
Inhibition of protein kinase C function by injection of intracellular receptors for the enzyme.
Smith BL, Mochly-Rosen D. (1992) Biochem. Biophys. Res. Commun. 188(3):1235-40 [PubMed]
Nicotinic acetylcholine receptor desensitization is regulated by activation-induced extracellular adenosine accumulation.
Pitchford S, Day JW, Gordon A, Mochly-Rosen D. (1992) J. Neurosci. 12(11):4540-4 [PubMed]
Inhibition of c-Jun DNA binding by mitogen-activated protein kinase.
Chou SY, Baichwal V, Ferrell JE. (1992) Mol. Biol. Cell 3(10):1117-30 [PubMed]
p65 fragments, homologous to the C2 region of protein kinase C, bind to the intracellular receptors for protein kinase C.
Mochly-Rosen D, Miller KG, Scheller RH, Khaner H, Lopez J, Smith BL. (1992) Biochemistry 31(35):8120-4 [PubMed]
Alcoholism: a possible G protein disorder.
Gordon AS, MOCHLY-ROSEN D, Diamond I. In G proteins, signal transduction and disease. Milligan G, Wakelam MJO (eds). Academic Press, Ltd., London, pp 191-216, 1992.
Decoding calcium signals by multifunctional CaM kinase.
Schulman H, Hanson PI, Meyer T. (1992) Cell Calcium 13(6-7):401-11 [PubMed]
Calmodulin trapping by calcium-calmodulin-dependent protein kinase.
Meyer T, Hanson PI, Stryer L, Schulman H. (1992) Science 256(5060):1199-202 [PubMed]
Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity.
Liu J, Albers MW, Wandless TJ, Luan S, Alberg DG, Belshaw PJ, Cohen P, MacKintosh C, Klee CB, Schreiber SL. (1992) Biochemistry 31(16):3896-901 [PubMed]
Association of the beta isoform of protein kinase C with vimentin filaments.
Spudich A, Meyer T, Stryer L. (1992) Cell Motil. Cytoskeleton 22(4):250-6 [PubMed]
Immunophilin-ligand complexes as probes of intracellular signaling pathways.
Schreiber SL, Liu J, Albers MW, Karmacharya R, Koh E, Martin PK, Rosen MK, Standaert RF, Wandless TJ. (1991) Transplant. Proc. 23(6):2839-44 [PubMed]
Intracellular receptors for activated protein kinase C. Identification of a binding site for the enzyme.
Mochly-Rosen D, Khaner H, Lopez J, Smith BL. (1991) J. Biol. Chem. 266(23):14866-8 [PubMed]
Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin.
Michnick SW, Rosen MK, Wandless TJ, Karplus M, Schreiber SL. (1991) Science 252(5007):836-9 [PubMed]
Identification of intracellular receptor proteins for activated protein kinase C.
Mochly-Rosen D, Khaner H, Lopez J. (1991) Proc. Natl. Acad. Sci. U.S.A. 88(9):3997-4000 [PubMed]
Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs.
Ferrell JE, Wu M, Gerhart JC, Martin GS. (1991) Mol. Cell. Biol. 11(4):1965-71 [PubMed]
The identification and purification of a mammalian-like protein kinase C in the yeast Saccharomyces cerevisiae.
Simon AJ, Milner Y, Saville SP, Dvir A, Mochly-Rosen D, Orr E. (1991) Proc. Biol. Sci. 243(1307):165-71 [PubMed]
Cell signaling by second messenger waves.
Meyer T. (1991) Cell 64(4):675-8 [PubMed]
Assessing activities of blotted protein kinases.
Ferrell JE, Martin GS. (1991) Meth. Enzymol. 200:430-5 [PubMed]
G protein and alcoholism.
Gordon AS, Mochly-Rosen D, Diamond I. In Dysfunction of G-protein linked cascades in cellular pathology. Milligan G and Wakelam MJO (eds). Academic Press, 1991.
The role of adenosine and adenosine transport in ethanol-induced cellular tolerance and dependence. Possible biologic and genetic markers of alcoholism.
Diamond I, Nagy L, Mochly-Rosen D, Gordon A. (1991) Ann. N. Y. Acad. Sci. 625:473-87 [PubMed]
Calcium spiking.
Meyer T, Stryer L. (1991) Annu Rev Biophys Biophys Chem 20:153-74 [PubMed]
GTP-binding proteins are restricted to signal transduction sites.
Mochly-Rosen D, Gordon AS. (1990) Biochem. Biophys. Res. Commun. 173(1):388-95 [PubMed]
Probing immunosuppressant action with a nonnatural immunophilin ligand.
Bierer BE, Somers PK, Wandless TJ, Burakoff SJ, Schreiber SL. (1990) Science 250(4980):556-9 [PubMed]
Reduced adenosine receptor activation in alcoholism: implications for alcohol withdrawal seizures.
Diamond I, Mochly-Rosen D, Gordon AS. In Alcohol and seizures: basic mechanisms and clinical concepts. Porter R, Mattson R, Kramer J and Diamond I (eds). FA Davis, Philadelphia, pp 79-86, 1990.
A protein kinase C isozyme is translocated to cytoskeletal elements on activation.
Mochly-Rosen D, Henrich CJ, Cheever L, Khaner H, Simpson PC. (1990) Cell Regul. 1(9):693-706 [PubMed]
Intracellular localization of pp60c-src in human platelets.
Ferrell JE, Noble JA, Martin GS, Jacques YV, Bainton DF. (1990) Oncogene 5(7):1033-6 [PubMed]
Identification of a 42-kilodalton phosphotyrosyl protein as a serine(threonine) protein kinase by renaturation.
Ferrell JE, Martin GS. (1990) Mol. Cell. Biol. 10(6):3020-6 [PubMed]
Transient calcium release induced by successive increments of inositol 1,4,5-trisphosphate.
Meyer T, Stryer L. (1990) Proc. Natl. Acad. Sci. U.S.A. 87(10):3841-5 [PubMed]
Kinetics of calcium channel opening by inositol 1,4,5-trisphosphate.
Meyer T, Wensel T, Stryer L. (1990) Biochemistry 29(1):32-7 [PubMed]
Chronic ethanol-induced heterologous desensitization is mediated by changes in adenosine transport.
Gordon AS, Nagy L, Mochly-Rosen D, Diamond I. (1990) Biochem. Soc. Symp. 56:117-36 [PubMed]