Stanford School of Medicine

Chemical & Systems Biology


Seminar: Cutting Lecture – Michael Levine

Posted by CSB Department on January 17, 2014

Speaker: Michael Levine, Ph.D.

Title: “Mechanisms of transcriptional precision in animal development.”

Abstract: The Drosophila embryo is defined by the rapid deployment of stripes and bands of gene expression that define the basic blueprint of the adult fly.  In a period of just 60 minutes, crude gradient of maternal regulatory proteins such as Bicoid and Dorsal give way to precise on/off patterns of zygotic gene expression. I will highlight the importance of transcriptional enhancers in this process and present live-imaging analysis of the eve stripe 2 enhancer. These studies provide new insights into mechanisms of transcriptional repression and also suggest that paused Pol II might suppress developmental noise by inhibiting transcription bursts at the core promoter.
Summarizing our efforts to use the tadpole of the simple model chordate, Ciona intestinalis, to explore the evolutionary origins of vertebrate cranial placodes.  I hope to present evidence that the hypothalamus-pituitary axis arose from a common progenitor cell that possesses the features of vomeronasal chemosensory neurons and GnRH-expressing neurosecretory cells.

Time: Friday, January 17, 2014   12:00 PM - 1:00 PM

Location: Munzer Auditorium

Contact: Marisol Urbano ‒ 650-725-5091 ‒ urbano@stanford.edu